ProtoArray microarrays are high-density, functional protein microarrays that enable rapid elucidation of protein interactions on a proteome scale. For your convenience, we have compiled references that describe applications of this powerful technology.

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  • Pugh C et al. (2014) Human Antibody Responses to the Polyclonal Dryvax Vaccine for Smallpox Prevention Can Be Distinguished from Responses to the Monoclonal Replacement Vaccine ACAM2000. Clin Vaccine Immunol. 21: 877.
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  • Keasey SL et al. (2009) Extensive Antibody Cross-reactivity among Infectious Gram-negative Bacteria Revealed by Proteome Microarray Analysis. Mol Cell Proteomics. 8: 924.
  • Haseda F et al. (2016) Antibody to CMRF35-Like Molecule 2, CD300e A Novel Biomarker Detected in Patients with Fulminant Type 1 Diabetes. PLoS One. 11: e0160576. 
  • Meyer S et al. (2016) AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies. Cell 166: 582. 
  • Sridharan V et al. (2016) Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer. Br J Cancer 115: 252. 
  • Li Y et al. (2016) p27 is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma. Cancer Res. 76: 4002. 
  • DeMarshall CA et al. (2016) Detection of Alzheimer’s disease at mild cognitive impairment and disease progression using autoantibodies as blood-based biomarkers. Alzheimer’s & Dementia 3: 51. 
  • Chang DC et al. (2015) Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion. PLoS One. 10:e0143551. 
  • DeMarshall CA et al. (2015) Potential utility of autoantibodies as blood-based biomarkers for early detection and diagnosis of Parkinson's disease. Immunol Lett. 168: 80. 
  • Furukawa H et al. (2015) Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD. Biomark Insights 10: 63. 
  • GuhaThakurta D et al. (2015) Humoral Immune Response against Nontargeted Tumor Antigens after Treatment with Sipuleucel-T and its Association with Improved Clinical Outcome. Clin Cancer Res. 21: 3619. 
  • Landegren N et al. (2015) Transglutaminase 4 as a prostate autoantigen in male subfertility. Sci Transl Med 7:292. 
  • Goto K et al. (2015) Identification of Cerebral Infarction-Specific Antibody Markers from Autoantibodies Detected in Patients with Systemic Lupus Erythematosus. J Mol Biomark Diagn. 6:219 
  • Antoine JC et al. (2015) Antifibroblast growth factor receptor 3 antibodies identify a subgroup of patients with sensory neuropathy. J Neurol Neurosurg Psychiatry. 86: 1347. 
  • Jackson AM et al (2015) Endothelial cell antibodies associated with novel targets and increased rejection. J Am Soc Nephrol. 26: 1161. 
  • Woo SH et al. (2015) Mapping Novel Immunogenic Epitopes in IgA Nephropathy. Clin J Am Soc Nephrol. 10: 372. 
  • Piesche M et al. (2015) Angiogenic cytokines are antibody targets during graft-versus-leukemia reactions. Clin Cancer Res. 21: 1010. 
  • Kinloch AJ et al. (2014) Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis. Arthritis Rheumatol. 66: 3359. 
  • Kim SH et al. (2014) Autoimmunity as a Candidate for the Etiopathogenesis of Meniere's Disease: Detection of Autoimmune Reactions and Diagnostic Biomarker Candidate. PLoS One. 9: e111039. 
  • Delville M et al. (2014) A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation. Sci Transl Med 6: 256ra136 
  • Taguchi A et al. (2014) A Search for Novel Cancer/Testis Antigens in Lung Cancer Identifies VCX/Y Genes, Expanding the Repertoire of Potential Immunotherapeutic Targets. Cancer Res. 74: 4694. 
  • Kim YG et al. (2014) Role of Protein Phosphatase Magnesium-Dependent 1A and Anti-Protein Phosphatase Magnesium-Dependent 1A Autoantibodies in Ankylosing Spondylitis. Arthritis Rheumatol. 66: 2793. 
  • Hodi FS et al. (2014) Bevacizumab plus Ipilimumab in Patients with Metastatic Melanoma. Cancer Immunol Res. 2: 632. 
  • Koo BK et al. (2014) Identification of Novel Autoantibodies in Type 1 Diabetic Patients Using a High-Density Protein Microarray. Diabetes 63: 3022. 
  • Mias GI et al. (2014) Specific plasma autoantibody reactivity in myelodysplastic syndromes. Sci Rep. 3: 3311. 
  • Motts JA et al. (2014) Novel biomarkers of mercury-induced autoimmune dysfunction: A cross-sectional study in Amazonian Brazil. Eviron Res. 132C: 12-18. 
  • Bonsignori M et al. (2014) An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. J Clin Invest. 124: 1835-1843. 
  • Dema B et al. (2014) Autoreactive IgE Is Prevalent in Systemic Lupus Erythematosus and Is Associated with Increased Disease Activity and Nephritis. PLoS One. 9: e90424. 
  • May C et al. (2014) Highly Immunoreactive IgG Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array. PLoS One. 9: e89596. 
  • Hommel B et al. (2014) Chronic Malaria Revealed by a New Fluorescence Pattern on the Antinuclear Autoantibodies Test. PLoS One. 9: e88548. 
  • Beatty GL et al. (2014) Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies. Cancer Immunol Res. 2: 112. 
  • Mias GI et al. (2013) Specific Plasma Autoantibody Reactivity in Myelodysplastic Syndromes. Sci Rep 3: 3311. 
  • Querol L et al. (2013) Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology. 81: 956-963. 
  • Nagele EP et al. (2013) Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease. PLoS One. 8: e60726. 
  • Sidgel T et al. (2013) Immune response profiling identifies autoantibodies specific to Moyamoya patients. Orphanet J Rare Dis. 8: 45. 
  • Néron S and Roy A (2012) Overview of IgG-Reactivity in Therapeutic immunoglobulins Revealed by Protein Array Analysis. Biochem Anal Biochem S8: 001. 
  • Ghevaria N et al. (2012) Quality control for a large-scale study using protein arrays and protein beads to measure immune response in serum and plasma. Proteomics 12: 2802-2807.
  • Sidgel et al. (2012) Non-HLA Antibodies to Immunogenic Epitopes Predict the Evolution of Chronic Renal Allograft Injury. J Am Soc Nephrol. 23: 750-763.
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  • Liu M et al. (2012) Immune responses to self-antigens in asthma patients: clinical and immunopathological implications. Hum Immunol. 73: 511-516.
  • Postow MA et al. (2012) Immunologic correlates of the abscopal effect in a patient with melanoma. NEJM. 366: 925-931.
  • Han M et al. (2012) Diagnosis of Parkinson’s disease based on disease-specific autoantibody profiles in human sera. PLoS One. 7: e32383.
  • Mangé A et al. (2012) Serum autoantibody signature of ductal carcinoma in situ progression to invasive breast cancer. Clin Cancer Res. 18: 1992-2000.
  • Wood JD et al. (2012) Anti-Enteric Neuronal Antibodies and the Irritable Bowel Syndrome. J Neurogastroenterol Motil. 18: 78-85.
  • Biernacki MA et al. (2012) Novel myeloma-associated antigens revealed in the context of syngeneic
  • hematopoietic stem cell transplantation. Blood. 119: 3142-3150.
  • Sigdel TK et al. (2011) Profiling of Autoantibodies in IgA Nephropathy, an Integrative Antibiomics Approach. Clin J Am Soc Nephrol. 6: 2775-2784.
  • Jansen FH et al. (2011) Profiling of antibody production against xenograft-released proteins by protein microarrays discovers prostate cancer markers. J. Proteome Res. 11: 728-735.
  • Winer DA et al. (2011) B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat. Med 17: 610-618.
  • Hu S et al. (2011) Identification of autoantibody biomarkers for primary Sjögren’s syndrome using protein microarrays. Proteomics. 11: 1499-1507.
  • Nagele E et al. (2011) Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera. PLoS One. 6: e23112.
  • Dinavahi R et al. (2011) Antibodies reactive to non-HLA antigens in transplant glomerulopathy. J Am Soc Nephrol. 22: 1168-1178.
  • Vermeulen N et al. (2011) Identification of a novel autoantigen in inflammatory bowel disease by a protein microarray. Inflamm Bowel Dis. 17: 1291-1300.
  • Butte AJ et al. (2011) Protein Microarrays Discover Angiotensinogen and PRKRIP1 as Novel Targets for Autoantibodies in Chronic Renal Disease. Mol Cell Proteomics. 10: M110.000497.
  • Gnjatic S et al. (2010) Seromic profiling of ovarian and pancreatic cancer. Proc. Natl. Acad. Sci. USA, 107: 5088–5093.
  • Le Roux S et al. (2010) Biomarkers for the Diagnosis of the Stable Kidney Transplant and Chronic Transplant Injury Using the ProtoArray® Technology. Transplant Proc. 42: 3475-3481
  • Nguyen MC et al. (2010) Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy. Cancer Immunol Immunother. 59:1313-1323.
  • Porcheray F et al. (2010) Chronic Humoral Rejection of Human Kidney Allografts Associates With Broad Autoantibody Responses. Transplantation. 89: 1239-1246.
  • Jarius S et al. (2010) A new Purkinje cell antibody (anti-Ca) associated with subacute cerebellar ataxia: immunological characterization. J Neuroinflammation. 7: 21.
  • Orenes-Piñero E et al. (2010) Serum and Tissue Profiling in Bladder Cancer Combining Protein and Tissue Arrays. J Proteome Res. 9: 164-173.
  • Marina O et al. (2010) Serologic Markers of Effective Tumor Immunity against Chronic Lymphocytic Leukemia Include Nonmutated B-Cell Antigens. Cancer Res. 70: 1344-1355.
  • Li L et al. (2010) Compartmental Localization and Clinical Relevance of MICA Antibodies After Renal Transplantation. Transplantation. 89: 312-319.
  • Wadia PP et al. (2010) Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation. Blood. 115: 2077-2087.
  • Biernacki MA et al. (2010) Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells. Cancer Res. 70: 906–915.
  • Schweitzer B et al. (2010) Immune response biomarker profiling application on ProtoArray protein microarrays. Methods Mol Biol. 641:243-52.
  • Babel I et al. (2009) Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays. Mol Cell Proteomics. 8: 2382–2395.
  • Sutherland SM et al. (2009) Protein microarrays identify antibodies to protein kinase Cζ that are associated with a greater risk of allograft loss in pediatric renal transplant recipients. Kidney Int. 76: 1277–1283.
  • Li L et al. (2009) Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and “antibodyome” measures. Proc Natl Acad Sci USA. 106: 4148–4153.
  • Auger I et al. (2009) New autoantigens in rheumatoid arthritis: screening 8268 protein arrays with RA patients’ sera. Ann Rheum Dis. 68: 591–594.
  • Gunawardana CG et al. (2009) Identifying novel autoantibody signatures in ovarian cancer using high-density protein microarrays. Clin Biochem. 42: 426–429.
  • Gnjatic S et al. (2009) Seromic analysis of antibody responses in non-small cell lung cancer patients and healthy donors using conformational protein arrays. J Immunol Methods. 341: 50–58.
  • Roche S et al. (2008) Autoantibody profiling on high-density protein microarrays for biomarker discovery in the cerebrospinal fluid. J Immunol Methods. 338: 75-78.
  • Hudson ME et al. (2007) Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays. Proc Natl Acad Sci USA. 104: 17494-17499.
  • Lubomirski M et al. (2007) A consolidated approach to analyzing data from high-throughput protein microarrays with an application to immune response profiling in humans. J Comput Biol. 14: 350-359.
  • Lalive PH et al. (2006) Identification of new serum autoantibodies in neuromyelitis optica using protein microarrays. Neurology. 67: 176-177.
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  • Keasey SL et al. (2016) Cell-free determination of binary complexes that comprise extended protein-protein interaction networks of Yersinia pestis. Mol Cell Proteomics. 15: 3220. 
  • Herling TW et al. (2016) A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions. Biophys J. 110: 1957. 
  • Dunning CJ et al. (2016) Direct High Affinity Interaction between Ab42 and GSK3a Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease? ACS Chem Neruosci. 7: 161. 
  • Ho JC et al. (2016) Targeting of nucleotide-binding proteins by HAMLET-a conserved tumor cell death mechanism. Oncogene. 35: 897. 
  • Müller J et al (2015) TRIM21, a negative modulator of LFG in breast carcinoma MDA-MB-231 cells in vitro. Int J Oncol. 47: 1634. 
  • Lu WJ et al (2015) NDRG1 promotes growth of hepatocellular carcinoma cells by directly interacting with GSK-3b and Nur77 to prevent b-catenin degradation. Oncotarget 6: 29847. 
  • Chua HH et al. (2015) RBMY, a novel inhibitor of GSK3b, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma. Hepatology 62: 1480. 
  • Burgardt NI et al. (2015) Parvulin 17-catalyzed Tubulin Polymerization Is Regulated by Calmodulin in a Calcium-dependent Manner. J Biol Chem 290: 16708. 
  • Beilina A et al (2014) Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. PNAS 111(7): 2626-2631. 
  • Reyniers L et al. (2014) Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways. J Neurochem.131: 239-50.
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  • Lalioti VS et al. (2014) Sorcin Links Calcium Signaling to Vesicle Trafficking, Regulates Polo-Like Kinase 1 and Is Necessary for Mitosis. PLOS One 9: e85438. 
  • Miyajima M et al. (2013) Leucine-Rich α2-Glycoprotein Is a Novel Biomarker of Neurodegenerative Disease in Human Cerebrospinal Fluid and Causes Neurodegeneration in Mouse Cerebral Cortex. PLoS One 8: e77453. 
  • Tsuru M et al. (2013) Proline/arginine-rich end leucine-rich repeat protein converts stem cells to ligament tissue and Zn(II) influences its nuclear expression. Stem Cells Dev. 22: 2057 
  • Chen TC et al. (2013) Protein Phosphorylation Profiling Using an In Situ Proximity Ligation Assay: Phosphorylation of AURKA-Elicited EGFR-Thr654 and EGFR-Ser1046 in Lung Cancer Cells. PLoS One 8: e55657. 
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  • Binder M et al. (2013) CLL B-cell receptors can recognize themselves: alternative epitopes and structural clues for autostimulatory mechanisms in CLL. Blood 121: 239-241. 
  • Pitek AS et al. (2012) Transferrin Coated Nanoparticles: Study of the Bionano Interface in Human Plasma. PLoS One 7: e40685.
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  • Virok DP et al. (2011) Protein Array Based Interactome Analysis of Amyloid-β Indicates an Inhibition of Protein Translation. J. Proteome Res. 10: 1538–1547.
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