Fast, easy, automated end-to-end next-generation sequencing workflow that delivers NGS test results in as little as 24 hours

The Ion Torrent Genexus System is a two-instrument next-generation sequencing (NGS) platform that automates the main steps in the NGS workflow, including sample purification and quantification, library preparation, sequencing, bioinformatics analysis, and reporting.


The Genexus Purification System and Genexus Integrated Sequencer work together seamlessly with Genexus software, tracking sample information and results automatically through the process. This automated system reduces manual steps and facilitates quality data and quick reports, making in-house NGS testing accessible to more researchers regardless of experience and without the requirement to hire or train additional staff.

The Genexus System makes in-house NGS more accessible

NGS has come a long way to be right where you need it

The Genexus System makes the NGS workflow fast and easy with walkaway automation, so laboratories of all experience levels are able to access the benefits of in-house NGS. These advancements to the NGS workflow provide a new level of operational efficiency by reducing hands-on time and staff required for NGS testing, freeing up valuable time to focus on other priorities or to scale up the testing done in the lab.


The Genexus System NGS platform also increases reproducibility of NGS assays and provides long-term cost savings due to decreased labor requirements and combined service and support options by using multiple instruments from the same trusted partner. 

How does the Genexus System work?

The Genexus System consists of two integrated instruments linked by a single intuitive Genexus software for simplified sample input, run plan setup, data analysis, and report generation.


In the first step of this automated NGS workflow, the Genexus Purification System quickly extracts and quantifies nucleic acids with hands-free walkaway automation, eliminating manual pipetting steps from sample preparation. Next, the Genexus Integrated Sequencer automates library prep, templating, sequencing, data analysis and reporting, delivering the only true end-to-end automated NGS workflow specifically optimized to work together from a single company.

Genexus System instruments

Genexus Purification System

The Genexus Purification System automates nucleic acid extraction, purification, and quantitation on a single platform for consistent and efficient NGS sample preparation. With a streamlined workflow and minimal hands-on time, you can go from sample to NGS-ready plate in just minutes, ready to be loaded onto the Genexus Integrated Sequencer.

Genexus Integrated Sequencer

The Genexus Integrated Sequencer automates NGS library preparation, sequencing, and analysis. When paired with the Genexus Purification System, the two-instrument-plus-software system delivers a complete workflow solution. With workflow automation, sequencing performance, and automated data analysis and reporting, the Genexus System brings NGS to any lab without the need for extensive sequencing or bioinformatics expertise.

Details of the Genexus System workflow

The automated Genexus System workflow minimizes hands-on time to deliver NGS test results quickly and easily, making rapid in-house NGS assays accessible to more laboratories without the requirement for previous NGS experience or extensive training.


With just two manual touchpoints, one for setting up the automated sample purification run on the Genexus Purification System and the other for setting up automated library preparation, sequencing, analysis, and reporting on the Genexus Integrated Sequencer, and a total of 20 minutes of hands-on time for the entire workflow, NGS has become almost as accessible as assays like PCR or IHC.

Figure 1: The Genexus System is two instruments connected by one software.

The Genexus System is used by clinical researchers and laboratory technicians to complete NGS tests. Our Ion AmpliSeq assays are sensitive and easy to implement for laboratory use. Assays come with primer pools and many assays come with bioinformatics and reporting mechanisms.

Oncology research solutions

Oncomine solutions used with the Genexus System provide a complete NGS testing workflow from sample to report. The time to complete the workflow is comparable to other methods, including IHC, yet provides full genomic profiling. Multiple Oncomine assays are available on the Genexus System to assay key biomarkers found in multiple cancers.

Oncomine assays are available for a range of clinical research applications:

  • Genomic profiling
  • Liquid biopsies
  • Hematological malignancies
  • Immuno-oncology

Reproductive health research solutions

Understanding risk factors for inherited genetic disorders is an important step in evaluating reproductive options. Preimplantation genetic testing for aneuploidy (PGT-A) offers critical insights that may increase the probability of success for future pregnancies and healthier future generations.






Inherited disease research solutions

Studying heritable diseases can be challenging. Ion AmpliSeq On-Demand panels allow you to build custom panels from over 5,000 pretested genes that are most relevant in research on inherited diseases, including hereditary cancer, primary immunodeficiency, hearing loss, muscular dystrophy, and more. This is a simplified method to bring NGS into a laboratory.

Infectious disease research solutions

Ion Torrent NGS technology is based on ultra-high-multiplex PCR, the same technology that has enabled public health agencies to closely monitor viral infections. This includes assays to complete SARS-CoV-2 viral genome sequencing and variant identification.


Design your own panels

The Ion AmpliSeq Designer helps you obtain custom assays with minimal time and effort. This web tool leads you through the steps and choices to build custom primer panels.

Step 1: Name your panel and add any identifying details
Step 2: Choose an application type
Step 3: Choose DNA type

To browse predesigned panels and explore designing your own custom solutions, visit

Instrument analytical validation and maintenance services

Access hands-on training at your research lab, on-site service plans, self-paced online courses, remote support options, and consulting services to help you get the most from your product.


Learn from scientists, clinical researchers, and other laboratory personnel how to use automated workflows and the Genexus System.

Brochure: The Genexus System

NGS ebook: Introduction to next-generation sequencing

Tech note: Comparison of hands-on time in NGS workflows for the Genexus and MiSeq systems

Additional resources