High throughput screening with multiwell plates

Improved specificity for high-confidence screening results

Silencer Select siRNAs incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemical modifications to yield siRNAs with unrivalled efficacy, potency, and specificity.

Improve RNAi screening results with highly efficient, specific siRNAs

The benefits of Silencer Select siRNAs are amplified in the context of high-throughput screening applications. Trust your discovery to the siRNA with our knockdown guarantee in the industry!

AttributesAdvantages
  • Advanced bioinformatic seed region analysis for sequence selection
  • LNA chemical modifications
  • Reduced off-target effects by up to 90% for fewer false positives
  • Less toxicity due to off-target effects
  • More consistent phenotypic data
  • Next-generation design algorithm
  • Up to 100-fold more potent silencing than other available siRNAs
  • Improved silencing for more robust knockdown results
  • Fewer false negatives for greater experimental confidence
  • Three unique individual siRNAs per gene
  • Multiple data points per gene for rapid progression from primary screening to hit confirmation studies

If you’re ready to start screening with a pre-defined collection or want to request a custom library, request a quote now!

Request a quote 

Pre-defined Silencer Select siRNA libraries

These libraries have been pre-assembled using PANTHER (www.pantherdb.org ) and Gene Ontology™ annotation information to create up-to-date target gene sets.

  • Each gene is targeted by three unique siRNAs. Validated siRNAs are included at no extra cost.
  • 0.25 nmol of each siRNA is provided dried-down in the wells of barcoded 96- or 384-well plates. This is sufficient for 100-500+ transfections, depending on siRNA working concentration and reaction volume.
  • Column 12 of each 96-well plate and columns 23 and 24 in each 384-well plate are left empty to allow for the addition of controls at the time of use.
  • Plates are conveniently arranged for pooling of siRNA, if desired.
  • The libraries are delivered with plate map files including full siRNA sequence information, as well as each targeted gene's symbol, full name, aliases, RefSeq accession, and Entrez Gene ID.

If you would like more information on any of the libraries listed below, click the product link or email us at RNAisupport@thermofisher.com
 

Custom Silencer Select siRNA libraries

Silencer Select siRNAs are available as custom collections to suit your specific needs. These highly economical plated versions of our guaranteed siRNAs are perfect for pilot studies, primary screen follow-up, or a customized functional genomics screen.

  • Minimum order of 20 siRNAs
  • Up to 3 siRNAs per gene
  • Choose from 96-well, 384-well, or 384-well Echo-qualified plates
  • Validated siRNAs are available at no additional cost!
     
Product line for custom siRNA librariesQuantity per well*
Silencer Select human pre-designed inventoried siRNA 0.1, 0.25, 1, or 2 nmol
*NOTE: Not all quantities available in 384-well

Publications featuring Silencer Select siRNA libraries

Since 2010, Silencer Select siRNA libraries have been enabling functional genomics studies in labs around the world. These selected peer-reviewed references showcase the power of our high-quality siRNAs in high-throughput screening applications.

Pre-defined Silencer Select siRNA libraries

These libraries have been pre-assembled using PANTHER (www.pantherdb.org ) and Gene Ontology™ annotation information to create up-to-date target gene sets.

  • Each gene is targeted by three unique siRNAs. Validated siRNAs are included at no extra cost.
  • 0.25 nmol of each siRNA is provided dried-down in the wells of barcoded 96- or 384-well plates. This is sufficient for 100-500+ transfections, depending on siRNA working concentration and reaction volume.
  • Column 12 of each 96-well plate and columns 23 and 24 in each 384-well plate are left empty to allow for the addition of controls at the time of use.
  • Plates are conveniently arranged for pooling of siRNA, if desired.
  • The libraries are delivered with plate map files including full siRNA sequence information, as well as each targeted gene's symbol, full name, aliases, RefSeq accession, and Entrez Gene ID.

If you would like more information on any of the libraries listed below, click the product link or email us at RNAisupport@thermofisher.com
 

Custom Silencer Select siRNA libraries

Silencer Select siRNAs are available as custom collections to suit your specific needs. These highly economical plated versions of our guaranteed siRNAs are perfect for pilot studies, primary screen follow-up, or a customized functional genomics screen.

  • Minimum order of 20 siRNAs
  • Up to 3 siRNAs per gene
  • Choose from 96-well, 384-well, or 384-well Echo-qualified plates
  • Validated siRNAs are available at no additional cost!
     
Product line for custom siRNA librariesQuantity per well*
Silencer Select human pre-designed inventoried siRNA 0.1, 0.25, 1, or 2 nmol
*NOTE: Not all quantities available in 384-well

Publications featuring Silencer Select siRNA libraries

Since 2010, Silencer Select siRNA libraries have been enabling functional genomics studies in labs around the world. These selected peer-reviewed references showcase the power of our high-quality siRNAs in high-throughput screening applications.

Questions?

If you have any questions on products or ordering, please contact us at RNAiSupport@thermofisher.com