QuantiGene Plex Gene Expression Assay Literature & Citations

Application notes

Gene expression and DNA copy number analysis in plants
New determination of gene signatures to subgroup melanoma patients using novel branched DNA hybridization assays
Transcript regulation of 18 ADME genes by prototypical inducers in human hepatocytes using QuantiGene Plex Assays

Technical guides

User manuals

QuantiGene sample processing kit product inserts

How-to videos

How to setup for Invitrogen™ QuantiGene™ Assays: Equipment, assay components, and storage conditions

How to calibrate incubators for the Invitrogen™ QuantiGene™ Singleplex and Plex Assays

How to prepare cell lysate and determine optimal sample input for Invitrogen™ QuantiGene™ Assays

How to perform hand-held magnetic plate washing for Invitrogen™ Luminex® based multiplex assays

How to set up and run an Invitrogen™ QuantiGene™ Plex Assay

How to set up an Invitrogen™ QuantiGene™ Plex Assay in the Luminex® xPONENT® Software

How to use the Invitrogen™ QuantiGene™ Plex Data Analysis App on the Thermo Fisher Connect Platform

Bibliography

QuantiGene Plex bibliography (2005 - 2015)

Application	Title	Year
Neuronal iron sequestration	Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein.	2022
Prednisolone AAV	Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression.	2022
Lung transplant	Ferret Lung Transplantation Models Differential Lymphoid Aggregate Morphology Between Restrictive and Obstructive Forms of Chronic Lung Allograft Dysfunction.	2022

Application	Title	Year
Checkpoint kinase inhibition	Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma.	2021
Rodent Burn Wounds	The impact of simultaneous inoculation of Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans on rodent burn wounds.	2021
Liver toxicity	Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-a Stabilization s.	2021
Liver drug metabolism	Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers.	2021
Thymus involution	T cell–depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution.	2021
Hepatic Steatosis	An ‘Omics Approach to Unraveling the Paradoxical Effect of Diet on Perfluorooctanesulfonic Acid (PFOS) and Perfluorononanoic Acid (PFNA)-Induced Hepatic Steatosis.	2021
Psoriasis	ACT1 Is Required for Murine IL-23–Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity.	2021
Epigenetics in Medulloblastoma	Loss of 5-Hydroxymethylcytosine as an Epigenetic Signature That Correlates With Poor Outcomes in Patients With Medulloblastoma.	2021
Lung Transplant COVID- 9	Emergency Lung Transplantation after COVID-19: Immunopathological Insights on Two Affected Patients.	2021
Hepatocellular Carcinoma	Interferon-Induced Transmembrane Protein 3 Expression Upregulation Is Involved in Progression of Hepatocellular Carcinoma.	2021
Huntingtons Disease Heat shock response	The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction.	2021
Staph aureus biofilms	A Facile High-Throughput Model of Surface-Independent Staphylococcus aureus Biofilms by Spontaneous Aggregation.	2021
Keratinocytes	Cannabidiol Protects Human Skin Keratinocytes from Hydrogen-Peroxide-Induced Oxidative Stress via Modulation of the Caspase-1–IL-1β Axis.	2021
Ankylosing spondylitis	Selective estrogen receptor modulator lasofoxifene suppresses spondyloarthritis manifestation and affects characteristics of gut microbiota in zymosan-induced SKG mice.	2021
Neurodegeneration	The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases.	2021
Psoriasis	Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in Psoriasis.	2021
Acute myeloid leukemia	Selective inhibition of the second bromodomain of BET family proteins results in robust antitumor activity in preclinical models of acute myeloid leukemia.	2021
Metabolic disease	Intestinal alteration of a-gustducin and sweet taste signaling pathway in metabolic diseases is partly rescued after weight loss and diabetes remission.	2021
Pregnancy SARS-CoV-2	MiRNA Profiling in Plasma and Placenta of SARS-CoV-2-Infected Pregnant Women.	2021
Huntingtons disease	Engagement of vascular early response genes typifies mild cognitive impairment.	2021
Horse Limb Wound Healing	Macroscopic, Histologic, and Immunomodulatory Response of Limb Wounds Following Intravenous Allogeneic Cord Blood-Derived Multipotent Mesenchymal Stromal Cell Therapy in Horses.	2021
SARS-CoV-2 immune response	Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals.	2021
Cellular proteostasis	Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy.	2021
Lupus	Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression.	2021
SARS-CoV-2 immunostimulation	Anti-Inflammatory Effects of Immunostimulation in Patients with COVID-19 Pneumonia.	2021

Application	Title	Year
Hippocampus	Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice.	2020
DNA methylation	Novel DNA methylation biomarkers for hexavalent chromium exposure: an epigenome-wide analysis.	2020
Colon cancer screening	High-throughput identification of protein functional similarities using a gene-expression-based siRNA screen.	2020
Atherosclerosis	Ficus deltoidea suppresses endothelial activation, inflammation, monocytes adhesion and oxidative stress via NF-κB and eNOS pathways in stimulated human coronary artery endothelial cells.	2020
HBV	Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes.	2020
IC50/EC50 potency testing	Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes.	2020
Breast Cancer	Technical validity of a customized assay of sensitivity to endocrine therapy using sections from fixed breast cancer tissue.	2020
Huntingtons disease	Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington’s disease models.	2020
Adipocyte	Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism.	2020

Application	Title	Year
Osteoarthritis	Evidence for Genetic Contribution to Variation in Posttraumatic Osteoarthritis in Mice.	2019
Renal Tubular Cells	GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.	2019
Embryogenesis	Annatto (Bixaorellana) δ-TCT Supplementation Protection against Embryonic Malformations through Alterations in PI3K/Akt-Cyclin D1 Pathway.	2019
Alzheimer's disease	Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer's Disease.	2019
Chicken immune response	Synthetic CpG-ODN rapidly enriches immune compartments in neonatal chicks to induce protective immunity against bacterial infections.	2019
RB-E2F transcriptional regulation	Context dependent roles for RB-E2F transcriptional regulation in tumor suppression.	2019
Yersinia infection	The responses of lungs and adjacent lymph nodes in responding to Yersinia pestis infection: A transcriptomic study using a non-human primate model.	2019
Spinal cord injury	Effect of lesion proximity on the regenerative response of long descending propriospinal neurons after spinal transection injury.	2019
P. aeruginosa wound infection	Formation of Pseudomonas aeruginosa Biofilms in Full-thickness Scald Burn Wounds in Rats.	2019
Mouse epididymal white adipose tissue	Alteration of myocardial GRK2 produces a global metabolic phenotype.	2019
Mouse 2-cell embryos	Annatto (Bixaorellana) δ-TCT Supplementation Protection against Embryonic Malformations through Alterations in PI3K/Akt-Cyclin D1 Pathway.	2019
NHP serum	Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics.	2019
Human oncology samples	Bead-based RNA multiplex panels for biomarker detection in oncology samples.	2019
Mouse cortex	Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer's Disease.	2019
Human blood	Combined bead-based multiplex detection of RNA and protein biomarkers: Implications for understanding the time course of skeletal muscle injury and repair.	2019
Mouse embryonic fibroblasts	Context dependent roles for RB-E2F transcriptional regulation in tumor suppression.	2019
Human decidua	Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy.	2019
Rat spinal cord	Effect of lesion proximity on the regenerative response of long descending propriospinal neurons after spinal transection injury.	2019
Mouse cerebellum, forebrain	eIF2B activator prevents neurological defects caused by a chronic integrated stress response.	2019
Mouse primary tissue (multiple)	Evidence for Genetic Contribution to Variation in Posttraumatic Osteoarthritis in Mice.	2019
Human PTEC-TERT1	GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.	2019
Mouse ear	IL-36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis.	2019
Human blood	Immune Pharmacodynamic Responses of the Novel Cancer Immunotherapeutic Imprime PGG in Healthy Volunteers.	2019
Rat stomach	In vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats.	2019
Human small intestine epithelial cells	Increased CXCR3+ T Cells Impairs Recruitment of T-Helper Type 17 Cells via Interferon γ and Interleukin 18 in the Small Intestine Mucosa During Treated HIV-1 Infection.	2019
Ferret stomach	Incretin dysfunction and hyperglycemia in cystic fibrosis: Role of acyl-ghrelin.	2019
Mouse ear	Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation.	2019
Human hepatocytes	Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor.	2019
Virus serum	Serum Hepatitis B Virus RNA: A New Potential Biomarker for Chronic Hepatitis B Virus Infection.	2019
Chicken lung, spleen	Synthetic CpG-ODN rapidly enriches immune compartments in neonatal chicks to induce protective immunity against bacterial infections.	2019
Human blood	The contribution of parent-to-offspring transmission of telomeres to the heritability of telomere length in humans.	2019
Human breast cancer	The genesis and evolution of bead-based multiplexing.	2019
NHP lung	The responses of lungs and adjacent lymph nodes in responding to Yersinia pestis infection: A transcriptomic study using a non-human primate model.	2019
Human mesenchymal stromal cells	Uniaxial Cyclic Tensile Stretching at 8% Strain Exclusively Promotes Tenogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells.	2019
Human dermis, epidermis	Validation of a predictive method for sunscreen formula evaluation using gene expression analysis in a Chinese reconstructed full-thickness skin model.	2019

Application	Title	Year
Mouse ileum, liver	Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion.	2018
Influenza vaccine safety	Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro.	2018
Lung Cancer Metastasis	GAP43, a novel metastasis promoter in non-small cell lung cancer.	2018
Murine encephalomyelitis virus	The influence of macrophage growth factors on Theiler's Murine Encephalomyelitis Virus (TMEV) infection and activation of macrophages.	2018
Lung Transplant Bronchiolitis	Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis.	2018
Genetically-modified crops	RNase If -treated quantitative PCR for dsRNA quantitation of RNAi trait in genetically modified crops.	2018
Breast Cancer	Interindividual Regulation of the Breast Cancer Resistance Protein ABCG2 Transporter in Term Human Placentas.	2018
Bile acid homeostasis	Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice.	2018
Influenza Vaccine Safety	In vitro marker gene expression analyses in human peripheral blood mononuclear cells: A tool to assess safety of influenza vaccines in humans.	2018
Cell Inflamed Tumor Microenvironment	The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade.	2018
PD- /PD-L antagonist	Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054.	2018
Acute Lymphoblastic Leukaemia	Effective Response Metric: a novel tool to predict relapse in childhood acute lymphoblastic leukaemia using time-series gene expression profiling.	2018
TGFβRI small molecule inhibitor	Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.	2018
Mesenchymal stromal cells	Comparison of Mesenchymal Stromal Cells Isolated from Murine Adipose Tissue and Bone Marrow in the Treatment of Spinal Cord Injury.	2018
Bipolar Disorder Research	Role of the IL-6-Receptor expression in CD14+ monocytes in modulating sleep in patients with bipolar disorder.	2018
HBV inhibitors	Identification of Retinoic Acid Receptor Agonists as Potent Hepatitis B Virus Inhibitors via a Drug Repurposing Screen.	2018
Influenza vaccine adjuvant	Establishment of a novel safety assessment method for vaccine adjuvant development.	2018
Alzheimer's disease	Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents.	2018
Shellfish Toxins Cao-2 cells	Detection and profiling of diarrheic marine biotoxins in shellfish by mRNA analysis of exposed Caco-2 cells using qRT-PCR and multiplex magnetic bead-based assays.	2018
Human melanoma	Analysis of NRAS gain in 657 patients with melanoma and evaluation of its sensitivity to a MEK inhibitor.	2018
Mouse ileum, liver	Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice.	2018
Mouse subcutaneous tissues	Biocompatibility of injectable resilin-based hydrogels.	2018
Human hepatocytes	Characterization of CYP2C Induction in Cryopreserved Human Hepatocytes and Its Application in the Prediction of the Clinical Consequences of the Induction.	2018
Mouse MC38 tumor	Choosing the Best Chemotherapy Agent to Boost Immune Checkpoint Inhibition Activity.	2018
Zebrafish larvae	Comparative effects of cadmium, zinc, arsenic and chromium on olfactory-mediated neurobehavior and gene expression in larval zebrafish (Danio rerio).	2018
Mouse bone marrow-derived mesenchymal stem cells	Comparison of Mesenchymal Stromal Cells Isolated from Murine Adipose Tissue and Bone Marrow in the Treatment of Spinal Cord Injury.	2018
Human HepaRG	Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells.	2018
Ferret lung	Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis.	2018
Human Caco-2	Detection and profiling of diarrheic marine biotoxins in shellfish by mRNA analysis of exposed Caco-2 cells using qRT-PCR and multiplex magnetic bead-based assays.	2018
Mouse lung	Development of a preclinical humanized mouse model to evaluate acute toxicity of an influenza vaccine.	2018
Mouse lung	Development of screening method for intranasal influenza vaccine and adjuvant safety in preclinical study.	2018
Human hepatocytes	Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro.	2018
Human cultured malaria-infected red blood cells	Direct Detection of Unamplified Pathogen RNA in Blood Lysate using an Integrated Lab-in-a-Stick Device and Ultrabright SERS Nanorattles.	2018
Human CD4 T cell-dendritic cell coculture	Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054.	2018
Human THP-1	Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy.	2018
Human blood	Effective Response Metric: a novel tool to predict relapse in childhood acute lymphoblastic leukaemia using time-series gene expression profiling.	2018
Human nasal-associated lymphoid tissue	Establishment of a novel safety assessment method for vaccine adjuvant development.	2018
Human liver	EXO1 overexpression is associated with poor prognosis of hepatocellular carcinoma patients.	2018
Mouse cornea	Fibroblast growth factor-2 drives and maintains progressive corneal neovascularization following HSV-1 infection.	2018
Human non-small cell lung cancer	GAP43, a novel metastasis promoter in non-small cell lung cancer.	2018
Human meniscus	Gene expression profiles of the meniscus avascular phenotype: A guide for meniscus tissue engineering.	2018
Human blood	Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal.	2018
Human gastrointestinal stromal tumor	Hydroxysteroid 11-Beta Dehydrogenase 1 Overexpression with Copy-Number Gain and Missense Mutations in Primary Gastrointestinal Stromal Tumors.	2018
Human hepatocytes	Identification of Retinoic Acid Receptor Agonists as Potent Hepatitis B Virus Inhibitors via a Drug Repurposing Screen.	2018
Human PBMC	In vitro marker gene expression analyses in human peripheral blood mononuclear cells: A tool to assess safety of influenza vaccines in humans.	2018
Human acral melanoma	Increased AURKA Gene Copy Number Correlates with Poor Prognosis and Predicts the Efficacy of High-dose Interferon Therapy in Acral Melanoma.	2018
Human PBMC	Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus.	2018
Human placenta	Interindividual Regulation of the Breast Cancer Resistance Protein ABCG2 Transporter in Term Human Placentas.	2018
Mouse lung	Modeling for influenza vaccines and adjuvants profile for safety prediction system using gene expression profiling and statistical tools.	2018
Mouse skeletal muscle	Multiplex Quantification Identifies Novel Exercise-regulated Myokines/Cytokines in Plasma and in Glycolytic and Oxidative Skeletal Muscle.	2018
Human breast cancer	Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material.	2018
Mouse kidney	Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus.	2018
Human brain	Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents.	2018
Rat kidney	Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease.	2018
Rat kidney	Prevention of chronic renal allograft rejection by AS2553627, a novel JAK inhibitor, in a rat transplantation model.	2018
Maize leaf	RNase If -treated quantitative PCR for dsRNA quantitation of RNAi trait in genetically modified crops.	2018
Human monocytes	Role of the IL-6-Receptor expression in CD14+ monocytes in modulating sleep in patients with bipolar disorder.	2018
Mouse CT26 tumor	Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.	2018
Human melanoma	TERT copy gain predicts the outcome of high-dose interferon α-2b therapy in acral melanoma.	2018
Mouse CT26 tumor, EMT6 tumor, MC38 tumor	The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade.	2018
Mouse bone marrow-derived macrophages	The influence of macrophage growth factors on Theiler's Murine Encephalomyelitis Virus (TMEV) infection and activation of macrophages.	2018

Application	Title	Year
Mouse lung	A novel vaccinological evaluation of intranasal vaccine and adjuvant safety for preclinical tests.	2017
Zebrafish larvae	A targeted gene expression platform allows for rapid analysis of chemical-induced antioxidant mRNA expression in zebrafish larvae.	2017
Human HepatoPac	Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4.	2017
Human brain	Assessment of vascularity in glioblastoma and its implications on patient outcomes.	2017
Human colorectal cancer	Association of TET1 expression with colorectal cancer progression.	2017
Human thymocytes	CD31, a Valuable Marker to Identify Early and Late Stages of T Cell Differentiation in the Human Thymus.	2017
Zebrafish larvae	Comparative Analysis of Vertebrate Diurnal/Circadian Transcriptomes.	2017
Rat stomach	Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats.	2017
Human colon	Crohn's Colitis: Development of a multiplex gene expression assay comparing mRNA levels of susceptibility genes.	2017
Human melanoma, Spitz nevus	Differential UBE2C and HOXA1 expression in melanocytic nevi and melanoma.	2017
Human medulloblastoma	Distinctive localization and MRI features correlate of molecular subgroups in adult medulloblastoma.	2017
Mouse liver	Editor's Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARα-Dependent Manner.	2017
Human subcutaneous adipose-derived stem cells	Editor's Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis.	2017
Salmon liver	Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon.	2017
Human colonic mucosa	Effect of cytomegalovirus and Epstein-Barr virus replication on intestinal mucosal gene expression and microbiome composition of HIV-infected and uninfected individuals.	2017
Human hair follicular cells	Effects of bright light exposure during daytime on peripheral clock gene expression in humans.	2017
Human PBMC	Endothelial dysfunction is associated with activation of the type I interferon system and platelets in patients with systemic lupus erythematosus.	2017
Mouse forepaw, hindpaw	Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model.	2017
Mouse lung	Evaluation of marker gene expression as a potential predictive marker of leukopenic toxicity for inactivated influenza vaccines.	2017
Human mesenchymal stem cells	Fate of tenogenic differentiation potential of human bone marrow stromal cells by uniaxial stretching affected by stretch-activated calcium channel agonist gadolinium.	2017
Human acral melanoma	Frequent Genetic Aberrations in the CDK4 Pathway in Acral Melanoma Indicate the Potential for CDK4/6 Inhibitors in Targeted Therapy.	2017
Human Tr1 cells	Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression.	2017
Human, Mouse OPM-2, skin, blood	HEXIM1 as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues.	2017
Human hCMEC/D3	HIV-1 Latency-Reversing Agents Prostratin and Bryostatin-1 Induce Blood-Brain Barrier Disruption/Inflammation and Modulate Leukocyte Adhesion/Transmigration.	2017
Human melanoma	Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy.	2017
Human HT1080	Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation.	2017
Mouse RAW 264.7	IFN-γ fails to overcome inhibition of selected macrophage activation events in response to pathogenic mycobacteria.	2017
Human adipocytes	Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue.	2017
Human renal proximal tubule epithelial cells	Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.	2017
Mouse RAW 264.7	INHIBITORY EFFECT OF EMODIN ON RAW 264.7 ACTIVATED WITH DOUBLE STRANDED RNA ANALOGUE POLY I:C.	2017
Mouse mouse embryonic fibroblasts	Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.	2017
Human colorectal cancer	LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer.	2017
Mouse hemibrain	Molecular indicators of stress-induced neuroinflammation in a mouse model simulating features of post-traumatic stress disorder.	2017
Mouse liver	Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control.	2017
Rat neurons	Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.	2017
Human blood	Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation.	2017
Human GIST48	PLCB4 copy gain and PLCß4 overexpression in primary gastrointestinal stromal tumors: Integrative characterization of a lipid-catabolizing enzyme associated with worse disease-free survival.	2017
Human SKM1	Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.	2017
Human gastric cancer	Prognostic value of a 25-gene assay in patients with gastric cancer after curative resection.	2017
Human PBMC	Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors.	2017
Human hepatocytes	Simple Evaluation Method for CYP3A4 Induction from Human Hepatocytes: The Relative Factor Approach with an Induction Detection Limit Concentration Based on the Emax Model.	2017
Maize root, grain, leaf	Single-Event Transgene Product Levels Predict Levels in Genetically Modified Breeding Stacks.	2017
Human endometrial stroma cells	Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells.	2017
Rat plasma	Systems Vaccinology Applied to DNA Vaccines: Perspective and Challenges.	2017
Mouse skin	Tbet is a critical modulator of FoxP3 expression in autoimmune graft -versus- host disease.	2017
Human leukocytes	The association between telomere length and mortality in Bangladesh.	2017
Rat heart	The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling.	2017
Human H1650	The Volume of Three-Dimensional Cultures of Cancer Cells InVitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors.	2017
Canine eye	Tolerability of Topical Tocilizumab Eyedrops in Dogs: A Pilot Study.	2017
Human MDA-MB-231 mouse xenograft	Tumor regression and modulation of gene expression via tumor-targeted tocotrienol niosomes.	2017
Rat cardiomyocytes	Ursodeoxycholic acid protects cardiomyocytes against cobalt chloride induced hypoxia by regulating transcriptional mediator of cells stress hypoxia inducible factor 1α and p53 protein.	2017
Human blood	Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration.	2017
Human HeLa	Visualization of self-delivering hydrophobically modified siRNA cellular internalization.	2017

Application	Title	Year
Mouse, Rat tibia	A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.	2016
Human acute myeloid leukemia	A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia.	2016
Ferret, Rabbit, Guinea Pig PBMC	A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation.	2016
Mouse ileum, liver	Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver.	2016
Human neonatal immature granulocytes	Alterations in neonatal neutrophil function attributable to increased immature forms.	2016
Mouse renal cortical tissue	Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis.	2016
Human keratinocytes	Anti-inflammatory and immunomodulatory effects of Aquaphilusdolomiae extract on in vitro models.	2016
Mouse RAW 264.7	Anti-inflammatory effects of oroxylin A on RAW 264.7 mouse macrophages induced with polyinosinic-polycytidylic acid.	2016
Human astrocytoma	Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas.	2016
Rat muscle	Biochemically engineered stromal cell-derived factor 1-alpha analog increases perfusion in the ischemic hind limb.	2016
Human blood	Blood transcriptional signature of recombinant human erythropoietin administration and implications for antidoping strategies.	2016
Human SW837	Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context.	2016
Yeast yeast cell pellets	Divergent MLS1 Promoters Lie on a Fitness Plateau for Gene Expression.	2016
Maize pollen, root, whole plant, grain, leaf	Ecological risk assessment for DvSnf7 RNA: A plant-incorporated protectant with targeted activity against western corn rootworm.	2016
Human hepatocytes	Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds.	2016
Human colorectal cancer	Evaluation and selection of a non-PCR based technology for improved gene expression profiling from clinical formalin-fixed, paraffin-embedded samples.	2016
Human hepatocytes	Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG Cells.	2016
Human A549	Grape Seed Procyanidin Extract Mediates Antineoplastic Effects against Lung Cancer via Modulations of Prostacyclin and 15-HETE Eicosanoid Pathways.	2016
Mouse liver	Hepatic Transporter Expression in Metabolic Syndrome: Phenotype, Serum Metabolic Hormones, and Transcription Factor Expression.	2016
Human tumor-infiltrating T cells	High-content molecular profiling of T-cell therapy in oncology.	2016
Human mammary tissue	Hormone Receptor Expression Analyses in Neoplastic and Non-Neoplastic Canine Mammary Tissue by a Bead Based Multiplex Branched DNA Assay: A Gene Expression Study in Fresh Frozen and Formalin-Fixed, Paraffin-Embedded Samples.	2016
Human adipocytes	Increased Basement Membrane Components in Adipose Tissue During Obesity: Links With TGFβ and Metabolic Phenotypes.	2016
Mouse brain	Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier	2016
Mosquito mosquitos	Larval application of sodium channel homologous dsRNA restores pyrethroid insecticide susceptibility in a resistant adult mosquito population.	2016
Canine mammary gland	Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines.	2016
Human vastus lateralis muscle	Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.	2016
Human urothelium	MCM10 overexpression implicates adverse prognosis in urothelial carcinoma.	2016
Human mammary tissue	Multiplex Gene Expression Profiling of 16 Target Genes in Neoplastic and Non-Neoplastic Canine Mammary Tissues Using Branched-DNA Assay.	2016
Human HepaRG	New Screening Criteria Setting on Evaluation of Cytochrome P450 Induction Using HepaRG Cells with Multiplex Branched DNA Technologies in Early Drug Discovery.	2016
Maize pollen	No impact of DvSnf7 RNA on honey bee (Apis mellifera L.) adults and larvae in dietary feeding tests.	2016
Mouse heart	Piper betle Induced Cytoprotective Genes and Proteins via the Nrf2/ARE Pathway in Aging Mice.	2016
Human WISH	Platelet-Derived S100A8/A9 and Cardiovascular Disease in Systemic Lupus Erythematosus.	2016
Human hepatocytes	Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model.	2016
Human gastric cancer	Recurrent amplification of MYC and TNFRSF11B in 8q24 is associated with poor survival in patients with gastric cancer.	2016
Human peripheral blood cells	Telomere length measurement by a novel Luminex-based assay: a blinded comparison to Southern blot.	2016
Mouse proximal colon	The Circadian Clock Mutation Promotes Intestinal Dysbiosis.	2016
Mouse lung	Therapeutic expansion of CD4+FoxP3+ regulatory T cells limits allergic airway inflammation during pulmonary fungal infection.	2016
Human ARPE-19	TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration.	2016
Human fibroblasts	Transcript, methylation and molecular docking analyses of the effects of HDAC inhibitors, SAHA and Dacinostat, on SMN2 expression in fibroblasts of SMA patients.< /a>	2016
Human gastrointestinal stromal tumor	Transcriptomic reappraisal identifies MGLL overexpression as an unfavorable prognosticator in primary gastrointestinal stromal tumors.	2016
Rat neonatal cardiomyocytes	Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2.	2016
Mouse tracheal tissue	Wnt Signaling Regulates Airway Epithelial Stem Cells in Adult Murine Submucosal Glands.	2016

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