Display of box, bottles, and bags from PureLink RNA Mini Kit for RNA Purification

The RNA purification process consists of a variety of unique challenges, one of which is ribonuclease contamination. Even a trace amount of RNase contamination can sabotage your experiments.

What is RNase?

RNase, or ribonuclease, is an enzyme found in all types of living cells. Its natural function is to catalyze the breakdown of RNA into smaller oligonucleotides.

Although RNase plays a critical role within an organism, it can be detrimental to laboratory experiments on RNA. Only a minimal amount of RNase contamination is sufficient enough to destroy any RNA being isolated and extracted. Contaminated reagents and environmental sources are the usual culprits in RNase contamination.

Avoid nuclease contamination in your RNA samples

Stop RNase contamination before your experiments are compromised with our catalog of RNA essentials.

Our decontamination solutions eliminate nuclease contamination (particularly ribonuclease) on work surfaces.

Stabilize and preserve the integrity of RNA either at the point of collection or even post-collection.

Certified nuclease-free (RNase- and DNase-free) tubes and tips designed for handling RNA and DNA with confidence.

Certified nuclease-free water products available in a wide range of sizes and packaging formats for molecular biology research.

RNase inhibitors are commonly used as a precautionary measure in enzymatic manipulations of RNA to inhibit and control for such contaminants.

RNA and DNA storage buffers, general-use buffers, and molecular biology-grade reagents-all rigorously tested and shown to be nuclease-free.

Nucleic acid purification & analysis support—we're here to help!

Our experts are here to help with application support, method development, and any other sample preparation questions you may have. Don't work in isolation. Contact us directly at techsupport@thermofisher.com.

For Research Use Only. Not for use in diagnostic procedures.