Thermo Scientific DNA Succinates are ideal for the derivatization of controlled pore glass, polystyrene or other supports to use in solid phase oligonucleotide synthesis.

RNA Controlled Pore Glass (CPG) Synthesis Supports are used in the automated synthesis of RNA oligonucleotides (oligoribonucleotides). The CPG support will not swell or shrink and is inert to the reagents used during synthesis. They are offered with a 500Å pore size, ideal for the synthesis of RNA oligonucleotides up to 50 bases in length. 

Custom manufactured and tested, RNA CPG supports can fulfill the specific needs of your oligo application.

For more than 40 years, our OEM and custom capabilities in research, development, and manufacturing of nucleic acids continue to be key resources for our global partners at molecular diagnostic, pharmaceutical, and life science research companies.

DNA succinates

Bz dA, Bz dC, iBu dG, and T Succinates are formulated as triethylammonium (TEA) salts with standard base protection. Our succinates provide the high quality and stringent manufacturing controls required for bench and therapeutic applications.

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 Bz dA SuccinateBz dC SuccinateiBu dG SuccinateT Succinate
Cat. No.27-003027-003227-003427-0036
Chemical name5′-O-(4,4'-Dimethoxytrityl)-N6-(benzoyl)-2′-deoxyadenosine-3′-succinate, Triethylammonium salt5′-O-(4,4'-Dimethoxytrityl)-N4-(benzoyl)-2′-deoxycytidine-3′-succinate, Triethylammonium salt5′-O-(4,4'-Dimethoxytrityl)-N2-(isobutyryl)-2′-deoxyguanosine-3′-succinate, Triethylammonium salt5′-O-(4,4'-Dimethoxytrityl)-thymidine-3′-succinate, Triethylammonium salt
Molecular weight859 g/mol835 g/mol841g/mol746 g/mol
HPLC purity≥ 98.0%≥ 98.0%≥ 95.0%≥ 98.0%
Shipping / Storage conditionAmbient / –20 °C
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RNA CPG synthesis supports

RNA Ac rC CPG, iPrPAC rG CPG, PAC rA CPG, and rU CPG are provided with 5′DMT and 2′TBDMS protection. Base protecting groups are easily removed under mild cleavage and deprotection conditions. Mild deprotection conditions reduce degradation during final deprotection and allow for incorporation of dyes and other chemical modifications which may be labile under harsh deprotection conditions.

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 Ac rC CPG supportiPrPAC rG CPG supportPAC rA CPG supportrU CPG support
Cat. No.SY6505SY6506SY6503SY6504
Description5′-O-(4,4′-Dimethoxytrityl)-N4-(acetyl)-2′-O-t-butyldimethylsilyl-Cytidine-3′-O-long chain alkyl amine controlled pore glass5′-O-(4,4′-Dimethoxytrityl)-N2-(isopropylphenoxyacetyl)-2′-O-t-butyldimethylsilyl-Guanosine-3′-O-long chain alkyl amine controlled pore glass5′-O-(4,4′-Dimethoxytrityl)-N6-(phenoxyacetyl)-2′-O-t-butyldimethylsilyl-adenosine-3′-O-long chain alkyl amine controlled pore glass5′-O-(4,4′-Dimethoxytrityl)-2′-O-t-butyldimethylsilyl-uridine-3′-O-long chain alkyl amine controlled pore glass
Pore size500 Å
Loading40 ± 5 µmol/g
IdentityConfirmation of base identity by UV analysis
Shipping / Storage conditionsAmbient / –20 °C
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Process and supply chain control

  • A controlled raw material supply chain and established vendor partnerships ensure consistency and security of supply
  • All DNA succinates are supplied with lot-specific quality control data including HPLC analyses
  • Processes are monitored from material procurement through final QC and product release, providing batch-to-batch reproducibility

Product configurations

  • Base modified CPG supports are available in a variety of pore sizes: 500 Å, 1000 Å, etc. Contact us to learn more

Custom services

  • Custom manufacturing services are available to assist you in your development or scale-up of succinates and synthesis supports, as well as selecting your preferred base and/or sugar modifications

Flexible packaging

  • Common oligo synthesizer pack sizes are available for immediate delivery
  • Custom and bulk packaging are also available. Contact us to learn more


Not finding what you are looking for? We also offer DNA phosphoramiditesRNA phosphoramiditesspecialty phosphoramiditesdye-labeled phosphoramidites2′-modifications, and linker and spacer phosphoramiditesContact us to learn more.