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Succinates and CPG Synthesis Supports |
Thermo Scientific DNA Succinates are ideal for the derivatization of controlled pore glass, polystyrene or other supports to use in solid phase oligonucleotide synthesis.
RNA Controlled Pore Glass (CPG) Synthesis Supports are used in the automated synthesis of RNA oligonucleotides (oligoribonucleotides). The CPG support will not swell or shrink and is inert to the reagents used during synthesis. They are offered with a 500Å pore size, ideal for the synthesis of RNA oligonucleotides up to 50 bases in length.
Custom manufactured and tested, RNA CPG supports can fulfill the specific needs of your oligo application.
For more than 40 years, our OEM and custom capabilities in research, development, and manufacturing of nucleic acids continue to be key resources for our global partners at molecular diagnostic, pharmaceutical, and life science research companies.
DNA succinates
Bz dA, Bz dC, iBu dG, and T Succinates are formulated as triethylammonium (TEA) salts with standard base protection. Our succinates provide the high quality and stringent manufacturing controls required for bench and therapeutic applications.
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Bz dA Succinate
dC Succinate
iBu dG Succinate
T Succinate
| Bz dA Succinate | Bz dC Succinate | iBu dG Succinate | T Succinate | |
|---|---|---|---|---|
| Cat. No. | 27-0030 | 27-0032 | 27-0034 | 27-0036 |
| Chemical name | 5′-O-(4,4'-Dimethoxytrityl)-N6-(benzoyl)-2′-deoxyadenosine-3′-succinate, Triethylammonium salt | 5′-O-(4,4'-Dimethoxytrityl)-N4-(benzoyl)-2′-deoxycytidine-3′-succinate, Triethylammonium salt | 5′-O-(4,4'-Dimethoxytrityl)-N2-(isobutyryl)-2′-deoxyguanosine-3′-succinate, Triethylammonium salt | 5′-O-(4,4'-Dimethoxytrityl)-thymidine-3′-succinate, Triethylammonium salt |
| Formula | C48H54N6O9 | C47H54N4O10 | C45H56N6O10 | C43H51N3O10 |
| Molecular weight | 859 g/mol | 835 g/mol | 841g/mol | 746 g/mol |
| HPLC purity | ≥ 98.0% | ≥ 98.0% | ≥ 95.0% | ≥ 98.0% |
| Shipping / Storage condition | Ambient / –20 °C | |||
| Request a quote | ||||
RNA CPG synthesis supports
RNA Ac rC CPG, iPrPAC rG CPG, PAC rA CPG, and rU CPG are provided with 5′DMT and 2′TBDMS protection. Base protecting groups are easily removed under mild cleavage and deprotection conditions. Mild deprotection conditions reduce degradation during final deprotection and allow for incorporation of dyes and other chemical modifications which may be labile under harsh deprotection conditions.
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Ac rC CPG support
iPrPAC rG CPG support
PAC rA CPG support
rU CPG support
| Ac rC CPG support | iPrPAC rG CPG support | PAC rA CPG support | rU CPG support | |
|---|---|---|---|---|
| Cat. No. | SY6505 | SY6506 | SY6503 | SY6504 |
| Description | 5′-O-(4,4′-Dimethoxytrityl)-N4-(acetyl)-2′-O-t-butyldimethylsilyl-Cytidine-3′-O-long chain alkyl amine controlled pore glass | 5′-O-(4,4′-Dimethoxytrityl)-N2-(isopropylphenoxyacetyl)-2′-O-t-butyldimethylsilyl-Guanosine-3′-O-long chain alkyl amine controlled pore glass | 5′-O-(4,4′-Dimethoxytrityl)-N6-(phenoxyacetyl)-2′-O-t-butyldimethylsilyl-adenosine-3′-O-long chain alkyl amine controlled pore glass | 5′-O-(4,4′-Dimethoxytrityl)-2′-O-t-butyldimethylsilyl-uridine-3′-O-long chain alkyl amine controlled pore glass |
| Pore size | 500 Å | |||
| Loading | 40 ± 5 µmol/g | |||
| Identity | Confirmation of base identity by UV analysis | |||
| Shipping / Storage conditions | Ambient / –20 °C | |||
| Request a quote | ||||
Process and supply chain control
- A controlled raw material supply chain and established vendor partnerships ensure consistency and security of supply
- All DNA succinates are supplied with lot-specific quality control data including HPLC analyses
- Processes are monitored from material procurement through final QC and product release, providing batch-to-batch reproducibility
Product configurations
- Base modified CPG supports are available in a variety of pore sizes: 500 Å, 1000 Å, etc. Contact us to learn more
Custom services
- Custom manufacturing services are available to assist you in your development or scale-up of succinates and synthesis supports, as well as selecting your preferred base and/or sugar modifications
Flexible packaging
- Common oligo synthesizer pack sizes are available for immediate delivery
- Custom and bulk packaging are also available. Contact us to learn more
Not finding what you are looking for? We also offer DNA phosphoramidites, RNA phosphoramidites, specialty phosphoramidites, dye-labeled phosphoramidites, 2′-modifications, and linker and spacer phosphoramidites. Contact us to learn more.
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