Organism Type Mouse The pancreatic beta-cell line has been established from insulinomas derived from transgenic mice carrying a hybrid insulin-promoted simian virus 40 tumor antigen gene. The cells produce both proinsulin I and II and efficiently process each into mature insulin, in a manner comparable to normal beta cells in isolated islets. Insulin secretion is inducible up to 30-fold by glucose, although with a lower threshold for maximal stimulation than that for normal beta cells.
Tissues Pancreas
Phenotype Adherent
Primary no
Application Cell Culture / Growth Conditions,Transient Transfection

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