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Beyond the box. Beyond the bottleneck.
Built to perform, the advanced Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer (MS) helps deliver streamlined, connected, and ready-to-run triple quadrupole workflows that keep your lab productive, profitable, and worry-free—no matter who’s at the bench.
With latest hardware for higher sensitivity and software for a compliant-ready solution, TSQ Certis Mass Spectrometer delivers greater uptime and improved performance for routine biopharmaceutical, clinical research, toxicology, environmental, and food safety testing laboratories.
TSQ Certis Mass Spectrometer
Next-gen productivity
Maximize throughput and efficiency in high-performance laboratories
- Exceptional scan speed of 900 SRM/s for high-throughput quantitation
- Faster acquisition speed enables shorter chromatographic runs and greater productivity
- Proactive alerts in the early warning system provide calibration-time and run-time warnings, thereby helping facilitate planned downtime of the instrument
Rugged and built to run
Advanced ion optics lead to increased uptime, delivering high profitability for fee-for-service customers
- Improved front-end ion vector extends performance and helps reduce maintenance
- Prolonged intervals between instrument cleanings, enabling tens of thousands of injections
- Mass filtering capabilities minimize contamination of quadrupoles
Improved performance
Newly engineered OptaMax Plus Ion Source maintains stability and precision of measurement across a vast range of methods and sample types
- Vaporizer temperatures up to 650oC
- Unlock greater sensitivities with elevated vaporizer temperatures
Software solutions for productivity and compliance
Go from sample to results with speed, confidence and compliance
- Thermo Scientific Chromeleon Chromatography Data System enables productivity and regulatory compliance with automated controls, data analysis, and security tools
- Thermo Scientific TraceFinder Software simplifies method setup with automated data acquisition, processing, and reporting
- Instrument control software (ICSW) includes read-to-use application templates already built into the method editors for meaningful results faster
Environmentally friendly dry pumps
Decrease both energy usage and instrument maintenance with an environmentally-friendly dry pump option
- Dry pump minimizes production of oil vapors and need for oil checks and changes
- ACT Ecolabel review underway for informed decision-making to meet sustainability objectives
Outstanding service and support
Obtain world-class service solutions for all your service and support needs
- Instrument service plans for standardized or tailored services that prioritize your needs
- On-demand services include compliance services, preventative maintenance, installation and education
One platform, endless applications
The TSQ Certis Mass Spectrometer delivers accuracy you can defend, traceability you can audit, and reproducibility you can trust—across biopharmaceutical, clinical research, toxicology environmental analysis, and food safety testing high-throughput routine labs who must make critical, compliance-driven health decisions.
Clinical research application: long-term instrument stability even with contaminant-heavy matrices
Analyzing human whole blood by LC-MS presents persistent challenges: matrix contaminants can accumulate within the ion source and API stack, compromising signal integrity and reproducibility. Restoring data quality demands time-consuming maintenance. The TSQ Certis Mass Spectrometer proves its durability by maintaining stable, precise performance through tens of thousands of injections—minimizing downtime and maximizing throughput.
Biopharmaceutical application: GLP-1 peptides and oligonucleotide bioanalysis
Demand for highly sensitive, specific, and stable methods for the bioanalysis of GLP-1 peptides and oligonucleotides is increasing. The development of LC-MS assays for GLP-1 peptides and oligonucleotide therapeutics has advanced rapidly as biopharmaceutical programs increasingly demand highly selective, quantitative methods for pharmacokinetic (PK) and biomarker studies. Both molecule classes present complex analytical challenges—GLP-1 analogs due to their size, instability, and endogenous background; oligonucleotides due to their polarity, charge, and susceptibility to degradation.
High sensitivity for challenging GLP-1 peptide analysis
By combining the Thermo Scientific Solaμ SAX SPE Extraction Plate with the TSQ Certis Triple Quadrupole Mass Spectrometer, laboratories can achieve exceptional sensitivity and specificity for GLP-1 peptides—reaching assay detection limits with greater confidence in target biomarker quantitation.
Accurate measurement of oligonucleotides
Liquid-liquid extraction of human plasma was used for quantitative bioanalysis of antisense oligonucleotides such as Fomivirsen and Nusinersen. The TSQ Certis Mass Spectrometer enables accurate measurement of oligonucleotides in challenging matrices such as plasma down to an LOQ of 0.1ng/mL.
Endocrinology application: superior performance for steroid quantitation
Liquid chromatography coupled with triple quadrupole (LC–QqQ) mass spectrometry has become the industry standard for the quantitative determination of steroids in biological matrices. Compared to immunoassays, LC–QqQ MS offers superior analytical specificity, lower detection limits, and improved reproducibility, making it ideal for regulated pharmacokinetic, endocrinological, and clinical research applications. The TSQ Certis Mass Spectrometer provides the speed, specificity, and ultra-high sensitivity necessary for reliable steroid quantitation.
For Research Use Only. Not for use in diagnostic procedures.