Hypersil GOLD HPLC and UHPLC Columns – Designed for optimum chromatography

Designed for optimum chromatography

Enjoy the range and capabilities of these state-of-the-art columns and gain confidence in the accuracy and quality of your analytical data. The Thermo Scientific Hypersil GOLD family of liquid chromatography (LC) columns is the culmination of 40 years of experience in the media and column product development and manufacturing.

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Improved sensitivity

Outstanding peak shape results in greater sensitivity. When peaks exhibit tailing, peak height is reduced, therefore compromising the sensitivity of analysis. The highly symmetrical peaks provided by Hypersil GOLD columns enhance peak height and allow for optimized peak integration calculations. This can be particularly critical when low concentrations of an analyte are present, such as in an impurity assay.


Hypersil GOLD column phase properties
PhasePhase Properties
Hypersil GOLD C18 Selectivity LC ColumnsExcellent peak shape for all analyte types.
Hypersil GOLD C8 LC ColumnsSimilar selectivity to C18 columns, but with reduced retention.
Hypersil GOLD C4 LC ColumnsSimilar selectivity to C18 and C8 columns, but with reduced retention.
Hypersil GOLD aQ LC ColumnsPolar endcapped C18 columns, stable in 100% aqueous mobile phase, providing enhanced retention and resolution of polar analytes.
Hypersil GOLD PFP LC ColumnsPerfluorinated phenyl columns offering alternative selectivity. The fluorine atoms around the phenyl ring enhance pi-pi interactions with aromatic molecules.
Hypersil GOLD Phenyl LC ColumnsExcellent retention and unique selectivity for aromatic analytes.
Hypersil GOLD Cyano LC ColumnsAlternative selectivity with lower hydrophobicity; can also be used for normal phase separations.
Hypersil GOLD Amino LC ColumnsCan be used in reversed phase, normal phase, ion exchange, and HILIC modes; particularly useful for separating carbohydrates.
Hypersil GOLD AX LC ColumnsSeparation of smaller proteins, peptides, anionic species, and polar molecules.
Hypersil GOLD SAX LC ColumnsA quaternary amino ion exchange ligand ideally suited to separating small polar organic analytes in aqueous mobile phases.
Hypersil GOLD Silica LC ColumnsSeparation of nonpolar and moderately polar organic compounds by normal phase chromatography.
Hypersil GOLD PEI HILIC LC ColumnsEnhanced retention of polar and hydrophilic analytes that are problematic using reversed phase columns.

Important product information

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