Separate polar, nonpolar, and ionizable compounds in a single analysis

Separate polar, nonpolar, and ionizable compounds in a single analysis

Do you want to separate ionic and hydrophobic analytes in a single run? Thermo Scientific™ mixed mode columns exhibit multiple functionalities and eliminate the need for column switching, ion paring, or using columns in series. The stationary phases of these columns mix reversed phase and ion exchange or HILIC functionality.

Mixed mode LC columns

Column

Recommended Use

Acclaim™ Trinity P1 LC Columns Simultaneously separate pharmaceutical drug substances and their counterions with high-efficiency. Functionalities: SCX, WAX and RP mixed mode.  
Acclaim™ Trinity P2 LC Columns Separates pharmaceutical counterions, including monovalent and divalent cations or anions. Functionalities: SAX, WCX and HILIC mixed mode.  
Acclaim™ Mixed Mode WCX-1 LC Columns Separates cationic molecules with powerful adjustable selectivity control. Functionalities: Reversed phase and WCX mixed mode.  
Acclaim™ Mixed Mode WAX-1 LC Columns Use this column when you need powerful selectivity control for the separation of anionic molecules. Functionalities: Reversed phase and WAX mixed mode.  
Acclaim™ Mixed Mode HILIC-1 LC Columns Get all the advantages of reversed phase and hydrophilic interaction liquid chromatography (HILIC) in this one column. Functionalities: Reversed phase and HILIC mixed model.  
OmniPac™ PAX-100 HPLC Columns Optimize separations of hydrophobic and halogenated anions using this solvent-compatible anion exchange column. Functionalities: Reversed phase and anion exchange mixed mode.  
OmniPac™ PAX-500 HPLC Columns Use this solvent-compatible column when you need to separate anionic and neutral species in a single run. Functionalities: Reversed phase and anion exchange mixed mode.
OmniPac™ PCX-100 HPLC Columns Separate hydrophobic cations using this solvent-compatible cation exchange column. Functionalities: Reversed phase and cation exchange mixed mode.
OmniPac™ PCX-500 HPLC Columns Separate cationic and neutral species in a single run using this solvent-compatible mixed mode column. Functionalities: Reversed phase and cation exchange mixed mode.
GlycanPac™ AXH-1 Glycan Analysis Column Perform qualitative, quantitative, and structural characterization of uncharged and charged glycans present in biological molecules. Functionalities: Anion exchange and reversed phase mixed mode.  
GlycanPac™ AXR-1 LC Columns Get ultra-high resolution and selectivity for both labeled and native glycans using this HPLC/UHPLC column. It’s compatible with MS and fluorescence detection. This high-performance, silica-based chromatography column achieves mixed-mode separation using a combination of charge, isomer structure, and size. Functionalities: Anion exchange and reversed phase mixed mode.  
Mixed Mode HPLC separations

What, Why and How. A journey into the possibilities of analysis used in mixed mode stationary phase interactions.

 

Mixed mode HPLC separations ›

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