See your biotherapeutics in high resolution

Analysis of biopharmaceutical therapeutic products demands the use of high quality HPLC and UHPLC columns to achieve high quality results. As leaders of innovative, reliable HPLC and UHPLC column development for over 40 years, you can trust Thermo Scientific columns to meet your needs for complex separations and analyses. Our columns for biomolecule separation – referred to as BioLC columns – were designed for high resolution, enhanced sensitivity, faster analyses, and consistent performance. Browse our recommended columns for your applications below.

HIC HPLC Columns for Intact Mass Analysis

SEC HPLC Columns for Aggregate Analysis

Charge Variant Analysis HPLC Columns

Oligonucleotide HPLC & UHPLC Columns

HIC HPLC columns for Intact Mass Analysis

SEC HPLC columns for Aggregate Analysis

Charge Variant Analysis HPLC columns

Oligonucleotide HPLC & UHPLC columns

  • Separate neutral mAbs from their aggregates based on hydrophobicity
  • Hydrophobic interaction chromatography (HIC)
  • Monitor mAb aggregates by their size
  • Size-exclusion chromatography (SEC)
  • Detect therapeutic protein modifications
  • Charge variant analysis by ion-exchange chromatography (IEC)
  • Separate oligonucleotide and nucleic acid mixtures including siRNA and mRNA
  • Anion-exchange and reversed phase (RP) column chemistries

MAbPac HIC-10

MAbPac HIC-20

MAbPac HIC-Butyl

MAbPac SEC-1

Acclaim SEC-300

Acclaim SEC-1000

ProPac Elite WCX

MAbPac SCX-10

ProPac SAX-10

CX-1 pH Buffers

DNAPac RP

DNAPac PA200(RS)

DNASwift

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HPLC Columns for Intact Mass & Subunit AnalysisAffinity Chromatography HPLC ColumnsHPLC & UHPLC Columns for Peptide Mapping & MAMHILIC HPLC Columns for Glycan Analysis

HPLC Columns for Intact Mass & Subunit Analysis

Affinity Chromatography HPLC Columns

HPLC & UHPLC Columns for Peptide Mapping & MAM

HILIC HPLC Columns for Glycan Analysis

  • Ideal for intact protein and subunit analysis
  • Reversed phase (RP) chromatography
  • Purify mAbs, mRNA, and AAV
    gene therapeutics
  • Affinity chromatography
  • Perform peptide mapping and Multi-Attribute Methods (MAM)
  • Reversed phase (RP) chromatography
  • Perform glycan analysis of neutral monoclonal antibodies and proteins
  • Hydrophilic interaction liquid chromatography (HILIC)

MAbPac RP

MAbPac Protein A

Hypersil GOLD Vanquish C18 UHPLC

Accucore Vanquish C18+

Accucore 150 Amide HILIC

mAb capture & affinity titer analysis

Aggregate analysis

Charge variant analysis

Antibody drug conjugates (ADCs) analysis using MS

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