Your solution for difficult separations in both reversed phase and normal phase HPLC and LC/MS applications

Porous graphitic carbon (PGC, Hypercarb™) has unique properties as a stationary phase in high-performance liquid chromatography (HPLC). Its chemical surface properties distinguish it from more conventional LC packings such as bonded-silica gels and polymers. PGC behaves as a strongly retentive alkyl-bonded silica gel for non-polar analytes.

However, its retention and selectivity behavior towards polar and structurally-related compounds is very different from conventional C18 columns.

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Features of Hypercarb columns

Thermo Scientific™ Hypercarb Porous Graphitic Carbon LC Columns offer:

  • Exceptional retention of very polar analytes
  • Separation for structurally-related substances
  • pH stablility from 0 to 14, and are not affected by aggressive mobile phases
  • Ideal solution for high-temperature applications


Physical properties of PGC
PropertyTo meet requirement of
Particle shape:SphericalNo micropores
Specific surface area:120 m2/gRetention linearity and loading capacity
Median pore diameter:250 ÅMass transfer for wide range of analyte shapes and sizes
Pore volume:0.7 m3/g 
Mean particle diameters:3 µm, 5 µmAnalytical HPLC columns
7 µmPreparative HPLC columns
30 µmSPE applications
Porosity:75%Mass transfer within particles
% C:100%Chemical stability
Mechanical strength:<400="">Operational particle stability; pressure gradients in packing process

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