Interleukin 8 is a pro-inflammatory factor which belongs to the CXC subfamily of chemokinesk, and which are bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and is a potent angiogenic factor. The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies.
alveolar macrophage chemotactic factor I; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; CXCL8; Emoctakin; GCP-1; GCP1; Granulocyte chemotactic protein 1; IL-8; interleukin 8; Interleukin-8; LECT; LUCT; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; LYNAP; MDNCF; MONAP; Monocyte-derived neutrophil chemotactic factor; Monocyte-derived neutrophil-activating peptide; NAF; NAP-1; neutrophil-activating peptide 1; Neutrophil-activating protein 1; Protein 3-10C; small inducible cytokine subfamily B, member 8; T-cell chemotactic factor; tumor necrosis factor-induced gene 1
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