Characterization of mAbs and their aggregates, fragments, and titers
Extensive development of protein and monoclonal antibody (mAb) therapeutics currently underway requires innovative and efficient tools that characterize and quantify structural variants and modifications, monitor product stability and demonstrate safety and efficacy. These specifically designed Thermo Scientific MAbPac columns provide a full range of high resolution, high efficiency mAb analyses by LC and LC-MS.
Now you can use reversed-phase conditions for higher resolution separation of intact mAbs and fragments by HPLC and LC-MS.
Use these columns for mAb, mAb fragment, antibody-drug aggregate, and related biologic separations.
Use these columns for fast and accurate titer analysis of monoclonal antibodies in harvest cell cultures.
Use these columns for high-resolution, high-efficiency analysis of mAbs and associated variants.
Choose these columns for optimal mAb analysis, including the high-resolution separation of monomers, aggregates and fragments.
Analysis |
Description |
Columns & Buffers |
|---|---|---|
| mAb Capture & titer analysis |
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| Aggregate analysis | Routing screening for mAb aggregates and fragments | |
| Charge variant analysis | Routine charge variant profiling/screening, including lysine truncation, deamidation & acylation | |
| Methionine & tryptophan oxidation | Targeted analysis of methionine and tryptophan oxidation | |
| Antibody drug conjugate (ADC) analysis | ADC DAR analysis | |
| Intact mAb & fragment analysis |
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| Sequence & structural analysis |
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| Glycan profiling | Profiling of released glycans |
This interactive tool will guide you through the products we offer for antibody analysis and purification. Start by selecting an area of interest to display relevant information. Continue making selections that interest you.
Over the past decade, there have been a growing number of mAb candidates entering the clinical pipeline. This results in a large increase on the demand for analytical characterization.
