Illustration depicting the column purification of a molecule

Thermo Fisher Scientific is your provider in purification.

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We work with you, so our resins work for you.

At Thermo Fisher Scientific, we are here to help you improve your purification process efficiency. In a complex world of biopharmaceuticals, vaccines, and gene therapies, you need a provider that is as focused as you are on delivering results. Our comprehensive resin portfolio is designed to help deliver innovative solutions that are scalable, and easily integrated into your platform to improve your process efficiency.

A platform for purification of all biotherapeutics

Infographic showing steps for manufacturing biotherapeutic platforms

Enabling high purity, helping deliver superior resolution, and designed for high throughput applications, our novel CaptureSelect and POROS resin technologies address today’s challenges in your purification workflow.  


Why Thermo Fisher Scientific?

Thermo Fisher Scientific is your provider in purification.

  • Years of experience: Leverage our years of experience as a world leader in serving science, with decades of involvement in FDA review of novel molecules.
  • Support at every stage: Engage our field application scientists to support your team through process development and scale up to commercial manufacturing. They are on hand to help assess your needs and solve complex purification challenges, which can save you time and money.
  • Comprehensive catalog of scalable resins: Integrate resins that are scalable, compatible with the equipment you already have, and designed for cGMP biotherapeutic manufacturing. We also offer custom resin development programs for tailored purification solutions.


Purification industry perspectives


Shop our purification solutions


Anion and cation exchange resins

                                                          Learn more

Thermo Scientific POROS anion exchange and cation exchange resins are the industry standard for large-scale polish chromatography applications. These POROS resins allow target molecule binding and impurity removal over a broad range of process conditions, thereby increasing process flexibility and manufacturing throughput.



Affinity chromatography resins      

                                                         Learn more

Our affinity resins are designed to deliver high purity and high yield of your target molecule in a single capture step. They are scalable and useful from bench-scale process development to commercial manufacturing of antibody therapeutics, biosimilars and recombinant proteins, vaccines, and gene therapies.



Hydrophobic interaction chromatography (HIC) resins 

                                                   Learn more

Browse our suite of POROS HIC resins offering a differentiating range in hydrophobicity suitable for bind/elute and flow-through applications. These resins can be utilized at lower salt concentrations for the purification of a wide variety of biomolecules.



Custom solutions      

                                                               Learn more

The manufacture of complex biotherapeutics requires novel purification strategies. Our custom ligand and chromatography resin services enable the development of innovative purification resins.


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Cell and gene therapies

                                                                          Learn more

To support the manufacturing of cell and gene therapies, we’ve developed innovative chromatography solutions, specifically designed to improve the downstream purification of mRNA and viral vectors such as the Adeno-Associated Virus (AAV), lentivirus, and Adv5.



Antibody therapheutics

                                                                 Learn more

Our CaptureSelect antibody subdomain-specific affinity chromatography resins are developed for the downstream purification of novel antibody modalities, such as bi-specific monoclonal antibodies, Fab fragments and Fc-fusion proteins, and can facilitate the process scale purification of a variety of antibody formats for commercial production of therapeutics.



Biosimilars and recombinant proteins

                                              Learn more

We’ve developed a unique portfolio of affinity resins to help you develop biosimilars, biobetters, and other types of recombinant proteins.



Vaccines

                                                                                                    Learn more

Thermo Scientific CaptureSelect and POROS resin technologies address purification challenges in the vaccine production workflow. We offer a variety of efficient and scalable resins for affinity, ion exchange, and hydrophobic interaction chromatography applications.


Illustration depicting a pre-packed chromatography column.

Our products in action

Case studies, webinars, and articles spotlighting Thermo Fisher Scientific purification solutions.

Optimizing AAV manufacture

With the potential to cure genetic disorders, gene therapies look set to revolutionize the field of medicine, and adeno-associated viruses have emerged as the vector of choice.

 

Read the article

Monoclonal antibody aggregate polish and viral clearance using hydrophobic-interaction chromatography

Discussion of aggregate clearance and viral clearance strategy on POROS HIC resins with novel ethyl and benzyl chemistries for the successful polish of mAbs A and B.

Read the article

Meeting the global demand for non-monoclonal antibody biosimilars

An overview of how new approaches to the manufacture of biosimilars have the potential to support sustainable access to critical non-monoclonal antibody biosimilars.
 

Read the article

Get in the mRNA vaccine race with affinity production

With demand for the large-scale production of clinical-grade mRNA suddenly surging, developers need fast, efficient, and highly scalable methods for mRNA purification.

Read the whitepaper

Bioprocessing resources

Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing: