BST2, also known as CD317, HM1.24 antigen, DAMP-2 and recently designated tetherin, is an integral membrane protein with a novel topology. The specific function of the BST2, encoded by the bone marrow stromal cell antigen 2 gene, is undetermined; however, it may play a role in pre-B-cell growth, rheumatoid arthritis, and in antiretroviral defense, that blocks release of retrovirus from the cell surface. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level).
2310015I10Rik; Bone marrow stromal antigen 2; Bone marrow stromal cell antigen 2; BST-2; C87040; CD317; DAMP-1; DAMP-1 protein homolog; GREG; HM1.24 antigen; PDCA-1; tetherin
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