Ep-CAM is a ~40 kD glycoprotein, which functions as an epithelial cell adhesion molecule. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions has a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is expressed in the majority of human carcinomas and is a marker for tumors of epithelial lineage.
CD326; DIAR5; EGP-2; EGP314; EGP40; Ep-CAM; EPCAM; Epithelial cell adhesion molecule; Epithelial glycoprotein 314; Epithelial Specific Antigen; KS1/4; lymphocyte antigen 74; M4S1; mEGP314; MIC18; MK-1; panepithelial glycoprotein 314; Protein 289A; TACSTD1; Trop-1 protein; TROP1; Tumor-associated calcium signal transducer 1
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