Browse bone biology pathways
Bones are an important tissue, providing support for the body, protecting organs, producing blood cells, and storing minerals. Several pathways are involved in bone development and growth as well as bone remodeling, including the BMP and RANK pathways.
Bone morphogenetic proteins (BMPs) are a large subclass of the transforming growth factor-beta (TGF-beta) superfamily.
RANKL and its receptor RANK are key regulators of bone remodeling, and are essential for the development and activation of osteoclasts.
RANKL induces the differentiation of osteoclast precursor cells and stimulates the resorption function and survival of mature osteoclasts.
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