Browse innate immunity pathways

Innate immunity is one of two ways by which vertebrates clear pathogens from the body. Unlike the adaptive immune system, the innate immune system does not provide long-term immunity to specific pathogens. A variety of cell signaling pathways are involved in this area of biology, including the angiopoietin-TIE2 signaling pathway, GSK3 signaling pathway, and CCR5 pathway in macrophages.


Angiopoietin-TIE2 Signaling

The angiopoietins are a new family of growth factor ligands that bind to TIE2/Tek TRK (Receptor Tyrosine Kinase).

CCR5 Pathway in Macrophages

CCR5 (Chemokine-CC Motif-Receptor-5) is a member of the chemokine receptor subclass of the GPCR (G-Protein-Coupled Receptor) superfamily.

Granulocyte Adhesion and Diapedesis

Adhesion and diapedesis of granulocytes have mostly been analyzed in context tonon-lymphoid endothelium.

Pathogenesis of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet.

Transendothelial Migration of Leukocytes

Transport of plasma proteins and solutes across the endothelium involves two different routes: transcellular and paracellular junctions.