Browse innate immunity pathways

Innate immunity is one of two ways by which vertebrates clear pathogens from the body. Unlike the adaptive immune system, the innate immune system does not provide long-term immunity to specific pathogens. A variety of cell signaling pathways are involved in this area of biology, including the angiopoietin-TIE2 signaling pathway, GSK3 signaling pathway, and CCR5 pathway in macrophages.

Angiopoietin-TIE2 Signaling

The angiopoietins are a new family of growth factor ligands that bind to TIE2/Tek TRK (Receptor Tyrosine Kinase).

CCR5 Pathway in Macrophages

CCR5 (Chemokine-CC Motif-Receptor-5) is a member of the chemokine receptor subclass of the GPCR (G-Protein-Coupled Receptor) superfamily.

Fas Signaling

FAS (also called APO1 or CD95) is a death domain–containing member of the tumor necrosis factor (TNF) receptor superfamily.

Granulocyte Adhesion and Diapedesis

Adhesion and diapedesis of granulocytes have mostly been analyzed in context tonon-lymphoid endothelium.

GSK3 Signaling

GSK3 is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes.

IL-6 Pathway

IL-6 is a pleiotropic cytokine that affects the immune system and many physiological events in various organs.

IL-22 Pathway

IL-22 is a member of the IL-10 family of cytokines and exerts multiple effects on the immune system.

Pathogenesis of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet.

Transendothelial Migration of Leukocytes

Transport of plasma proteins and solutes across the endothelium involves two different routes: transcellular and paracellular junctions.

TWEAK Pathway

TWEAK is a cell surface-associated protein belonging to the tumor necrosis factor (TNF) superfamily and has multiple biological activities.

Antibodies Resource Library

Access a targeted collection of scientific application notes, methods, and cell signaling charts.