Power every PCR with confidence and control

Image showing 96 well and 3x32 well block of PowerFlex thermal cycler

Introducing the next-generation Applied Biosystems PowerFlex Thermal Cycler—engineered to help deliver the reliable, accurate results you need to move your research forward with confidence.

Designed for precision and speed, PowerFlex allows advanced temperature gradient control, fast run times, and exceptional reproducibility. Available in 3 × 32-well and 96-well fixed block formats, it offers the flexibility to fit seamlessly into your workflow.

Why choose the PowerFlex Thermal Cycler?

  • Ultimate performance with excellent well-to-well uniformity, high temperature accuracy, and fast ramp rates
  • Flexible throughput options with broad compatibility across tubes, tube strips, and plates
  • Enhanced productivity through protocol flexibility and built-in tools for fast, accurate troubleshooting


Key benefits of the PowerFlex Thermal Cycler

  • Exceptional thermal precision and uniform performance
  • Full compatibility with multiple plate skirt formats
  • Increased laboratory productivity and workflow efficiency
  • Seamless protocol transfer and transition
  • Reduced downtime for uninterrupted operation
VeriFlex block technology showing various stacked elements that allow for advanced temperature gradient

Precise thermal performance 

  • Accuracy: ±0.15°C
  • Uniformity: <0.4°C at 95°C
  • Ramp rate: 7°C/sec
Full skirt pcr plate with PowerFlex 96 well thermal cycler

Fully compatible across different skirt types

Depending on the block type choose from:

  • Fully skirted plates
  • Semi skirted plates
  • Non-skirted plates
  • Tube strips
  • Single tubes
Image showing 3 separate blocks of advanced temperature gradient

Increase lab productivity

  • 3 × 32-well model features independent control, allowing up to three different experiments to run simultaneously, reducing wait times and increasing throughput in multi-user laboratories.
  • 96-well block for high-throughput applications
Image showing touch screen on protocol set up

Easy protocol transition

Streamline your workflow with seamless protocol migration to PowerFlex, saving time on setup.

Image showing smart help instrument troubleshooting

Minimize downtime

Built-in Smart Help minimizes downtime with fast, accurate troubleshooting. Submit support tickets directly from the instrument with log files automatically attached for quicker resolution

Discover the key features of PowerFlex Thermal Cycler, watch video


Choose the right PowerFlex Thermal Cycler model for your application

The PowerFlex Thermal Cycler is available in two fixed block configurations—3 × 32-well and 96-well—designed to support a wide range of laboratory throughput needs.

The 96-well block enables higher-throughput workflows and supports fully skirted plates, while the 3 × 32-well block offers independent control of three separate zones, allowing you to run up to three different protocols simultaneously with 32 reactions per block—maximizing flexibility and efficiency in your lab.

PowerFlex Thermal Cycler featuring 3 x 32-well plates

PowerFlex Thermal Cycler, 3 x 32-well

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PowerFlex Thermal Cycler featuring 1 x 96-well plate

PowerFlex Thermal Cycler, 1 x 96-well

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Data-driven insights into thermal cycler accuracy and performance

Application note: Thermal Cycler Temperature Accuracy

Discover how thermal cycler temperature accuracy directly impacts PCR success. This side-by-side study reveals real performance differences across leading systems—critical insights for confident annealing optimization and reproducible results. Download to see how your cycler stacks up.

Read here

Technical note: PowerFlex thermal cycler vs. ProFlex thermal cycler

See how the PowerFlex Thermal Cycler supports ProFlex-equivalent performance with faster ramp rates, higher accuracy, and smarter connectivity. This technical comparison shows how you can upgrade speed and usability without reoptimizing protocols. Download to explore the data behind the upgrade.

View now


Protect performance. Maximize uptime. Stay compliant.

Image showing service and support icon next to a PowerFlex thermal cycler

Service plans are designed to keep your instrument performing at its best—today and throughout its entire lifecycle. With flexible options tailored to your lab’s operational and compliance needs, you can reduce downtime, simplify maintenance, and maintain confidence in every result.

Choose the service plan that fits your workflow:

  • AB Repair Center ServiceExpert depot repair performed by certified professionals using genuine OEM parts to restore performance and reliability.
  • Rapid Exchange ServiceMinimize disruption with fast, hassle-free instrument replacement—so your lab stays up and running.
  • AB Repair Center with MDTV and Planned Maintenance (PM)A comprehensive depot repair solution that includes Multiplex Dynamic Temperature Verification (MDTV) and scheduled maintenance to support long-term performance and compliance.

Learn more at www.thermofisher.com/iqoqpq.

Resources

PCR and cDNA Synthesis Support Center
Tips and troubleshooting help.

PCR Thermal Cyclers Education
Technical content for new and experienced molecular biologists.

Thermal Cycler Software and Firmware Files
Download the latest updates for your instrument.

Interested in private label thermal cyclers?
Submit an inquiry

Support
Service

We offer a full range of service options for all Applied Biosystems thermal cyclers.

View service plans

Multiplex Dynamic Temperature Verification Service

Instrument qualification service: Have one of our engineers perform temperature qualifications at your site.

For Research Use Only. Not for use in diagnostic procedures.

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For Research Use Only. Not for use in diagnostic procedures.