Front angle on the SimpliAmp Thermal Cycler, including the user interface home screen

The Applied Biosystems SimpliAmp Thermal Cycler is an easy-to use, compact, and accurate thermal cycler designed to fit every lab’s essential PCR workflow. Innovations like a responsive color touch screen and Applied Biosystems VeriFlex temperature control technology enable simple, accurate optimization. And now you can access your SimpliAmp cycler with Thermo Fisher Connect, giving you the freedom to design and securely upload your methods from any mobile device or desktop computer.

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Simple, intuitive design for thermocyclers

The SimpliAmp Thermal Cycler has a large color graphical user interface for easy programming and quick checks of your run status at the bench. Simulation modes now make the transition from previous thermal cyclers to the SimpliAmp Thermal Cycler simple, accurate, and efficient.

Screenshot of the SimpliAmp Thermal Cycler splash screen from Applied Biosystems by Thermo Fisher Scientific
Screenshot of the SimpliAmp Thermal Cycler user interface Pre-Heating countdown to 95°C at 1:30:00 with icons such as “Sign In”, “New Method”, “Open Method”, “Incubate”, and “Settings”
Watch SimpliAmp Thermal Cycler customer stories

Watch Quy Nguyen, Research Associate II at Sanford Burnham Institute, discuss her use and recommendation of Applied Biosystems instruments, especially our simple thermal cycler, SimpliAmp Thermal Cycler.

Watch Ji-Young Nho, Medical Laboratory Technologist at U2 BIO, explain her use of Thermo Fisher PCR products and the SimpliAmp Thermal Cycler, an easy-to-use thermal cycler.

Stay in control with Thermal Cycler Fleet Control Software

Diagram of multiple thermal cyclers connected to one tablet to represent Fleet Control Software

Manage multiple users, methods, and instruments with a single intuitive interface securely behind your firewall.

Learn more about Thermal Cycler Fleet Control Software

Ordering information

High-performance PCR and qPCR plastics for optimal results

Five multi-colored PCR tube plates

Applied Biosystems PCR plastics have been designed and validated to work with our thermal cyclers for more than 25 years. Options for every format and throughput need are available to ensure consistent, precise results for end-point PCR applications. Quickly find the right fit and compatible plastics for your desired model and block formats by using our plastics selection guide.

Explore online PCR and qPCR plastics selection tool


Thermal Cycler Software and Firmware Files
Download the latest updates for your instrument

Interested in private label thermal cyclers?
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We provide a full range of service options for all Applied Biosystems thermal cyclers.

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Multiplex Dynamic Temperature Verification Service

Instrument qualification service: Have one of our engineers perform temperature qualifications at your site.

View temperature service options
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For Research Use Only. Not for use in diagnostic procedures.