Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Studies of LRRK2 (leucine-rich repeat kinase 2) function and inhibition have been hampered by a lack of tools to express full-length LRRK2 in diverse cell types as well as high-throughput biochemical and cell-based assays.
Now, LRRK2 researchers can access full-length protein, HTS assays and BacMam particles from Life Technologies that can be used to identify compounds that inhibit kinase activity in WT-LRRK2, the Parkinson’s disease-associated G2019S and other variants.
Poster: Express Full-Length LRRK2 and Profile Inhibitors using Cell-Based and Biochemical Assays
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV4873 | LRRK2 protein | 970-2527 | GST | Order | |||
A13388 | BacMam LRRK2 | 1 - 2527 | |||||
A14170 | BacMam LRRK2-GFP | 1 - 2527 | GFP |
| |||
A14171 | LRRK2-GFP Lysate | 1 - 2527 | GFP | Order | |||
A14685 | Lanthascreen LRRK2 (pSer935) Cellular assay kit | 1 - 2527 | GFP | ||||
A15197 | LRRK2 WT Full Length Protein (10 µg) | 1-2527 | DYKDDDDK | Order | |||
A15198 | LRRK2 WT Full Length Protein (100 µg) | 1-2527 | DYKDDDDK | Order | |||
A15199 | LRRK2 WT Full Length Protein (1 mg) | 1-2527 | DYKDDDDK | Order |
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV4881 | LRRK2 G2019S | 970-2527 | GST | Order | |||
A13389 | BacMam LRRK2 G2019S | 1 - 2527 | |||||
A14174 | BacMam LRRK2-GFP G2019S | 1 - 2527 | GFP |
|
| ||
A14172 | LRRK2-GFP G2019S Lysate | 1 - 2527 | GFP | Order | |||
A14686 | Lanthascreen LRRK2 G2019S (pSer935) Cellular assay kit | 1 - 2527 | GFP |
| |||
A15200 | LRRK2 WT Full Length Protein (10 µg) | 1-2527 | DYKDDDDK |
| Order | ||
A15201 | LRRK2 WT Full Length Protein (100 µg) | 1-2527 | DYKDDDDK | Order | |||
A15202 | LRRK2 WT Full Length Protein (1 mg) | 1-2527 | DYKDDDDK | Order |
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV6051 | LRRK2 D1994A protein | 970-2527 | GST |
Kinase "Dead" engineered Mutation (useful as a control) |
| Order | |
A13390 | BacMam LRRK2 D1994A | 1 - 2527 | |||||
Please inquire | BacMam LRRK2-GFP D1994A | 1 - 2527 | GFP |
|
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV4873 | LRRK2 protein | 970-2527 | GST | Order | |||
A13388 | BacMam LRRK2 | 1 - 2527 | |||||
A14170 | BacMam LRRK2-GFP | 1 - 2527 | GFP |
| |||
A14171 | LRRK2-GFP Lysate | 1 - 2527 | GFP | Order | |||
A14685 | Lanthascreen LRRK2 (pSer935) Cellular assay kit | 1 - 2527 | GFP | ||||
A15197 | LRRK2 WT Full Length Protein (10 µg) | 1-2527 | DYKDDDDK | Order | |||
A15198 | LRRK2 WT Full Length Protein (100 µg) | 1-2527 | DYKDDDDK | Order | |||
A15199 | LRRK2 WT Full Length Protein (1 mg) | 1-2527 | DYKDDDDK | Order |
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV4881 | LRRK2 G2019S | 970-2527 | GST | Order | |||
A13389 | BacMam LRRK2 G2019S | 1 - 2527 | |||||
A14174 | BacMam LRRK2-GFP G2019S | 1 - 2527 | GFP |
|
| ||
A14172 | LRRK2-GFP G2019S Lysate | 1 - 2527 | GFP | Order | |||
A14686 | Lanthascreen LRRK2 G2019S (pSer935) Cellular assay kit | 1 - 2527 | GFP |
| |||
A15200 | LRRK2 WT Full Length Protein (10 µg) | 1-2527 | DYKDDDDK |
| Order | ||
A15201 | LRRK2 WT Full Length Protein (100 µg) | 1-2527 | DYKDDDDK | Order | |||
A15202 | LRRK2 WT Full Length Protein (1 mg) | 1-2527 | DYKDDDDK | Order |
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV6051 | LRRK2 D1994A protein | 970-2527 | GST |
Kinase "Dead" engineered Mutation (useful as a control) |
| Order | |
A13390 | BacMam LRRK2 D1994A | 1 - 2527 | |||||
Please inquire | BacMam LRRK2-GFP D1994A | 1 - 2527 | GFP |
|
indicates reagents have been shown to work in assays. Biochemical assays include Adapta®, LanthaScreen® activity and Eu-kinase binding assays. Cellular assays include localization and activity assays measuring Ser935 phosphorylation. For specific assay functionality details, click the linked SKU numbers.
As part of our ongoing support of MJFF, consortium members may be eligible for special pricing. Please contact your sales representative for details. |
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For Research Use Only. Not for use in diagnostic procedures.
For Research Use Only. Not for use in diagnostic procedures.