Kinases for disease research

No matter your therapeutic area of research, Thermo Fisher Scientific provides a wide array of products and profiling services to support your drug discovery and development needs. From protein kinases, GPCR, nuclear receptors, ion channels and more, we have a long history of providing high-quality products, with the service and support you expect from a market leader in drug development.  

To help get you started on your journey to developing the next promising drug candidate or kinase inhibitor, here are a handful of the most-referenced Invitrogen protein kinase products for each therapeutic area. Alternatively, you can go straight to our selection and ordering tool.

Don’t see the protein kinase products or services you are looking for? Let our team of experts meet with you to find the best solution for your drug discovery and development needs at thermofisher.com/askdiscovery.

Cancer research kinases

Cancer Research Kinases

Cancer represents the largest research area currently being studied in any field of science and as such the discovery and development of kinase inhibitors that target cellular signaling responsible for tumor development, angiogenesis, cancer progression and metastasis, is inherent in anticancer prevention and treatments.

Thermo Fisher Scientific offers over 490 purified kinase proteins for therapeutic research and over 350 functional kinases that have been cited for cancer research in over 140,000 published papers.

To better understand the overall Thermo Fisher Scientific aim of pursuing a life without cancer view resources here.

See the full list of mutants and kinases for cancer research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
EGFR (ErbB1)15274PV3872
MET (CMET)8799PV3143
SRC8011P3044
MAPK3 (ERK1)7085 PV3311
ROS16245 PV3814
ERBB2 (HER2)4845 PV3366
BRAF4187PV3848
ATM3774  
ABL13525P3049
BCR3425  
CDK4 (cyclin D1)3187PV4400
PTK2 (FAK)3000PV3832
YES12955 A15557
CDK2/Cyclin A2869PV3267
AKT1 (PKB alpha)2560 P2999
ALK2362PV3867
KIT2072P3081
ATR2040  
RET1806PV3819
PDK11763 P3001
CHEK1 (CHK1)1756 P3040
JAK21724PV4210
CDK6/Cyclin D11670 PV4401
ABL2 (ARG)1636 PV3266
ErbB31588  
CHEK2 (CHK2)1557 PV3367
MAPK1 (ERK2)1530 PV3313
MERTK (cMER)1329 PV3627
MERTK (cMER) A708S1322 PV6325
LKB11305  
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Cancer research kinases

Cardiovascular disease research kinases

Cardiovascular Disease Research Kinases

The leading cause of death worldwide, cardiovascular diseases (CVDs) impacts all corners of the globe from industrialized nations to developing countries. Further complicated by the concurrent growth in common risk factors for cardiovascular disease such as obesity and diabetes, the need to better understand how the disease progresses and the development of novel therapeutic treats is vital.

As wide variety of conditions can lead to heart disease including atherosclerosis, heart infections and structural or congenital defects, cardiovascular drug development programs are often quite complex and require multidisciplinary approaches. Novel pharmacological strategies that target specific receptors or proteins involved in CVDs are required for the safe and effective treatment and prevention of cardiovascular disease.

Thermo Fisher Scientific has a wide variety of cardiovascular targets to help advance your research needs.

Thermo Fisher Scientific offers over 490 purified protein kinases for therapeutic research and over 210 functional kinases that have been cited for cancer research in over 3,300 published papers.

See the full list of mutants and kinases for cardiovascular research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
ROS1679 PV3814
MAPK3 (ERK1)280 PV3311
MET (CMET)255PV3143
SRC213P3044
EGFR (ErbB1)155PV3872
YES186 A15557
ABL2 (ARG)61 PV3266
KDR (VEGFR2)58 PV3660
KIT56P3081
AKT1 (PKB alpha)55 P2999
CSF1R (FMS)51 PV3249
MAPK8 (JNK1)49 PV3319
LKB146  
PDK145 P3001
JAK243PV4210
MAPK1 (ERK2)43 PV3313
PTK2 (FAK)43PV3832
ATM36  
MERTK (cMER)34 PV3627
ABL132P3049
AKT2 (PKB beta)27 PV3184
p70S6K27 PV6325
ULK127 PV6430
ROCK126 PV3691
TEK (TIE2)26PV3628
EIF2AK2 (PKR)23 PV4821
ERBB2 (HER2)23 PV3366
ERN122 A30971
IGF1R21 PV3250
FYN20P3042
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Cardiovascular disease research kinases

Central nervous system (CNS) disorders research kinases

Central Nervous System (CNS) Disorders Research Kinases

With a significant change in the average age of the world’s population, there has been a concerted shift in research focus into CNS disorders, like Parkinson’s disease, multiple sclerosis and Alzheimer’s disease. Historically, CNS research has focused on targeting extracellular receptors and their respective signaling pathways. Recent advances in antibodies, vaccines, interfering RNA, and other biological therapeutics have yielded promising treatment options for CNS disorders.

Thermo Fisher Scientific offers over 490 purified kinase proteins and paired assays and was the first to commercially offer purified full-length LRRK2 protein—key in Parkinson’s disease research.

We have over 280 kinases cited in over 7,400 published research papers. See the list of kinases for Alzheimer’s disease research, multiple sclerosis research, Parkinson’s disease research, and schizophrenia research below.

For more information regarding Thermo Fisher Scientific’s role in helping researchers unlock the mystery of Parkinson’s disease visit our resources here

See the full list of mutants and kinases for CNS disorders research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
ROS1123 PV3814
CDK5/p25109 PV4676
MAPK3 (ERK1)78 PV3311
SRC69P3044
MET (CMET)62PV3143
FYN51P3042
ABL2 (ARG)38 PV3266
LRRK226PV4873
NTRK1 (TRKA)24 PV3144
DYRK1A22 PV3785
MERTK (cMER)22 PV3627
NTRK2 (TRKB)21 PV3616
PINK121  
CDK1/Cyclin A119 PV6280
CDK2/Cyclin A18PV3267
EGFR (ErbB1)18PV3872
MAPK1 (ERK2)17 PV3313
MERTK (cMER) A708S15 PV6325
YES115 A15557
ABL114P3049
CDK4 (cyclin D1)14 PV4400
LKB113  
MAPK8 (JNK1)13 PV3319
MARK213 PV3878
EphB212 PV3625
PAK112 PV3820
GSK3B11 PV3365
ERN110 A30971
EIF2AK2 (PKR)9 PV4821
ERBB4 (HER4)9 PV3626
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Alzheimer's research kinases

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
ROS1367 PV3814
MAPK3 (ERK1)277 PV3311
MET (CMET)236PV3143
SRC190P3044
MERTK (cMER) A708S83 PV6325
EGFR (ErbB1)79PV3872
JAK279PV4210
YES179A15557
ABL172P3049
PINK169  
LRRK268PV4873
PDK166 P3001
FYN65P3042
ABL2 (ARG)64 PV3266
KIT63P3081
MAPK1 (ERK2)58 PV3313
NTRK2 (TRKB)57 PV3616
AKT1 (PKB alpha)56 P2999
EIF2AK2 (PKR)55 PV4821
TYK253 PV4790
CDK5/p2552 PV4676
LKB152  
BCR50  
PTK2 (FAK)50PV3832
JAK147 PV4774
CSF1R (FMS)43 PV3249
ULK143 PV6430
LYN A41PV6448
TBK141 PV3504
ERN140 A30971
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Multiple Sclerosis research kinases

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
PINK1165  
LRRK2162PV4873
ROS1100 PV3814
MET (CMET)47PV3143
MAPK3 (ERK1)33 PV3311
CDK5/p2520 PV4676
GAK16 A30973
PLK215 PV4204
ABL2 (ARG)14 PV3266
SRC14P3044
LRRK112  
MERTK (cMER)11 PV3627
YES110 A15557
ERN19 A30971
PLK39 PV3812
MAPK1 (ERK2)8 PV3313
EGFR (ErbB1)7PV3872
RET7PV3819
ULK17 PV6430
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Parkinson's disease research kinases

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
MET (CMET)215PV3143
ERBB4 (HER4)185 PV3626
MAPK3 (ERK1)111 PV3311
NTRK2 (TRKB)108 PV3616
AKT1 (PKB alpha)102 P2999
SRC91P3044
FYN63P3042
ROS159 PV3814
CDK5/p2553 PV4676
ErbB353  
YES146 A15557
MAPK1 (ERK2)40 PV3313
EGFR (ErbB1)39PV3872
ABL2 (ARG)25 PV3266
AKT3 (PKB gamma)22 PV3185
CAMK2A (CaMKII alpha)21 PV3142
FGFR121PV3146
PAK121 PV3820
ERBB2 (HER2)20 PV3366
GSK3B20 PV3365
PTK2B (FAK2)20 PV4567
LIMK118 PV4337
AKT2 (PKB beta)17 PV3184
NTRK3 (TRKC)17 PV3617
PAK317 PV3789
TNIK17 PV6427
NTRK1 (TRKA)16 PV3144
PDK116 P3001
CASK15 PV6271
PINK114  
RET14PV3819
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Schizophrenia research kinases

Inflammation research kinases

Inflammation Research Kinases

As our understanding of the mechanisms that control inflammatory responses improve, there is has been an increased emphasis on developing the next-generation inflammation kinase inhibitors and other drug candidates. Inflammatory diseases are associated with numerous debilitating diseases, including arthritis, inflammatory bowel disease, Crohn’s disease, psoriasis and atherosclerosis.

Thermo Fisher Scientific offers over 490 purified protein kinases for therapeutic research and over 310 kinases that have been cited in over 27,000 published papers. Let our drug discovery products help you develop more effective anti-inflammatory drug candidates.

See the full list of mutants and kinases for inflammation research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
ROS14030 PV3814
MAPK3 (ERK1)2501 PV3311
SRC1683P3044
MET (CMET)1314PV3143
EGFR (ErbB1)1044PV3872
JAK2648PV4210
MAPK8 (JNK1)606 PV3319
ABL2 (ARG)461 PV3266
SYK439 PV3857
JAK1418 PV4774
MAPK1 (ERK2)390 PV3313
ATM374  
YES1371 A15557
EIF2AK2 (PKR)367 PV4821
KIT357P3081
PTK2 (FAK)354PV3832
IRAK, pelle351 PV4403
MERTK (cMER)326 PV3627
BCR309  
MAP3K14 (NIK)301 PV4902
CSF1R (FMS)297 PV3249
AKT1 (PKB alpha)291 P2999
ABL1276P3049
LYN A258PV6448
TBK1249 PV3504
FYN233P3042
PDK1224 P3001
LCK218 P3043
CDK4 (cyclin D1)216 PV4400
JAK3214 PV3855
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Inflammation research kinases

Metabolic disorders research kinases

Metabolic Disorders Research Kinases

As the worldwide obesity rate continues to grow, there has been an increase emphasis on studying the complications associated with metabolic disorders, like type II diabetes and hyperlipidemia. The roles of cell surface receptors and their respective signaling pathways have become increasingly more important in metabolic research, as these receptors are vital in the regulation of insulin and glucagon secretion. As a result, developing fast-acting kinase inhibotors that can control the ways the body moderates metabolism and weight are at the forefront of many research endeavors.

Thermo Fisher Scientific offers over 490 purified protein kinases for therapeutic research and over 300 kinases that have been cited in over 14,000 published papers. See the list of kinases for diabetes research and hyperlipidemia research below.

See the full list of mutants and kinases for metabolic disorders research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
ROS12458 PV3814
MAPK3 (ERK1)1053 PV3311
MET (CMET)980PV3143
SRC690P3044
EGFR (ErbB1)566PV3872
LKB1397  
PDK1345 P3001
YES1340 A15557
AKT1 (PKB alpha)339 P2999
MAPK8 (JNK1)293 PV3319
AKT2 (PKB beta)282 PV3184
ABL2 (ARG)268 PV3266
JAK2254PV4210
ERN1235 A30971
MAP4K2 (GCK)233 PV4211
EIF2AK2 (PKR)227 PV4821
ATM198  
p70S6K193 PV6325
CDK5/p25173 PV4676
INSR169 PV3781
CDK4 (cyclin D1)159 PV4400
MAPK1 (ERK2)159 PV3313
IGF1R138 PV3250
CDK2/Cyclin A137PV3267
KDR (VEGFR2)120 PV3660
KIT107P3081
MERTK (cMER)107 PV3627
PTK2 (FAK)105PV3832
BCR97  
FYN95P3042
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Diabetes research kinases

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
ROS1101 PV3814
MAPK3 (ERK1)35 PV3311
SRC35P3044
MET (CMET)30PV3143
LKB117  
AKT2 (PKB beta)13 PV3184
YES113 A15557
FYN11P3042
JAK210PV4210
LYN A9PV6448
PDK19 P3001
EGFR (ErbB1)8PV3872
MAPK8 (JNK1)8 PV3319
AKT1 (PKB alpha)7 P2999
SIK17PV6445
SYK7 PV3857
aPKC6  
ERN16 A30971
FRAP1 (mTOR)6 PV4753
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Hyperlipidemia research kinases

Respiratory disease research kinases

Respiratory Disease Research Kinases

With increasing focus on public health and air quality, a renewed importance has been placed on the study of chronic respiratory diseases including asthma, lung cancer and chronic obstructive pulmonary disease (COPD).

Thermo Fisher Scientific offers over 490 purified protein kinases for therapeutic research and over 210 kinases that have been cited in over 3,300 published papers. See the list of kinases for asthma research, chronic obstructive pulmonary disease (COPD) research, and cystic fibrosis research below.

See the full list of mutants and kinases for respiratory disease research
Go to the kinase selection and ordering tool

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
MAPK3 (ERK1)218 PV3311
ROS1209 PV3814
SRC145P3044
MET (CMET)108PV3143
EGFR (ErbB1)103PV3872
KIT70P3081
SYK68 PV3857
JAK261PV4210
YES159 A15557
ABL2 (ARG)53 PV3266
JAK153 PV4774
LYN A48PV6448
BCR36  
FYN33P3042
JAK330 PV3855
LCK30 P3043
MAPK1 (ERK2)30 PV3313
TYK230 PV4790
CSF1R (FMS)28 PV3249
MAPK8 (JNK1)28 PV3319
TEC28 PV3269
AKT1 (PKB alpha)26 P2999
EIF2AK2 (PKR)26 PV4821
FLT326PV3182
ABL124P3049
ALK24PV3867
TNK2 (ACK)23 PV4807
BTK22 PV3363
MERTK (cMER)22 PV3627
PTK2 (FAK)20PV3832
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Asthma research kinases

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
MAPK3 (ERK1)81 PV3311
EGFR (ErbB1)74PV3872
MET (CMET)56PV3143
SRC42P3044
YES125 A15557
EIF2AK2 (PKR)20 PV4821
ROS120 PV3814
PTK2 (FAK)13 PV3832
PTK2B (FAK2)13 PV4567
ATM11  
MAPK8 (JNK1)11 PV3319
MERTK (cMER)11 PV3627
ABL110P3049
JAK210PV4210
RAF1 (cRAF) Y340D Y341D10PV3805
ALK9PV3867
MAPK1 (ERK2)9 PV3313
TNK2 (ACK)9 PV4807
ABL2 (ARG)8 PV3266
MERTK (cMER) A708S8 PV6325
BMPR27 PV6256
ERBB2 (HER2)7 PV3366
IRAK, pelle7 PV4403
SYK7 PV3857
ULK17 PV6430
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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COPD research kinases

No records were found matching your criteria

Protein kinaseNumber of citations*Mutants/variants available?Cat. No.
ROS172 PV3814
MET (CMET)64PV3143
MAPK3 (ERK1)56 PV3311
ABL2 (ARG)38 PV3266
SRC36P3044
EGFR (ErbB1)35PV3872
YES127 A15557
MERTK (cMER)20 PV3627
SGK (SGK1)20 PV3818
Wnk117 A33513
OXSR115 A30983
EIF2AK2 (PKR)14 PV4821
ERN114 A30971
MAPK1 (ERK2)12 PV3313
SYK11 PV3857
Wnk410  
LKB19  
PTK2B (FAK2)9PV3832
ERBB2 (HER2)8 PV3366
ATM7  
Wnk37 PV4342
*Reflects the number of published papers discovered from a “common name kinase” + “specific disease area” keyword search in PubMed Central over the period from January 2000 to August 2016.

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Cystic Fibrosis research kinases

Kinase selection guide

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