Proven Magnetic Separation Technology for Tumor Cells

Dynabeads are used within a variety of applications within the field of cancer research, ranging from detecting circulating tumor cells to expanding T cells in immunotherapy.

At a glance . . .

Circulating Tumor Cell Detection

  • Up to 5 log enrichment of tumor cells
  • Detect 1 tumor cell per ml of blood
  • Obtain viable cells for analysis by applications including staining, FISH, PCR or RT-PCR.

Isolate and detect minimal residual cancer cells with Dynabeads. These easy-to-use products quickly provide clear, sensitive and accurate results. The tube-based method is extremely gentle to cells, ensuring high cell viability and yield.

Tumour cell detection is a two part procedure:

  • Enrich tumor cells directly from whole blood, bone marrow or MNC samples
  • Analyze enriched tumor cells for characterization and confirmation


You can enrich tumour cells using Dynabeads coated with antibodies against specific cell markers. Add Dynabeads to the starting sample, which then bind to the target cells. Separate the bead-bound cells with a magnet (DynaMag). The product you choose will depend on your chosen downstream application.

Enriched tumor cells for molecular analysis:

Use Dynabeads Epithelial Enrich to positively isolate epithelial tumor cells from whole blood or bone marrow samples. After enrichment, obtain pure mRNA from the cells with Dynabeads mRNA DIRECT Kit.

Human and Mouse T Cell Expansion

Ready-to-use Dynabeads CD3/CD28 T Cell Expander provides a reliable way to repeatedly stimulate T cell clones without the need for autologous or MHC-matched antigen-presenting cells and antigen. Achieve full activation and expansion of T cells by providing simultaneous TCR/CD3 and CD28 signals to T cells in culture. Expanded T cells can be used in immunotherapy research.

Bridge the gap from mouse to human models with the equivalent product for expanding mouse cells, Dynabeads Mouse CD3/CD28 T Cell Expander.


Isolation and Expansion

Isolate a high yield and purity of human CD4+CD25+ cells with Dynabeads Regulatory CD4+CD25+ T Cell Kit.

Expand human regulatory T cells with Dynabeads Human Treg Expander. Expanded cells retain suppressive phenotype and capacity.


Immunotherapy

Dynabeads ClinExVivo CD3/CD28 (formerly Xcyte™ Dynabeads) offers a unique and proprietary technology for activation and expansion of autologous T cells to fight cancer and infectious disease. T cells expanded with Dynabeads ClinExVivo CD3/CD28 are currently being tested in clinical trials in patients with chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and multiple myeloma. Read more.


Angiogenesis

Isolate endothelial cells directly from tissue digests with Dynabeads CD31. For rapid and consistent results in protein or gene expression analysis, lyse the endothelial cells while they are still attached to the beads and directly process for further molecular analysis.