GC-MS Sample Preparation

Sample preparation methods for GC-MS

Gas chromatography mass spectrometry (GC-MS) sample preparation is performed on smaller and more volatile samples including environmental pollutants, industrial byproducts, food contaminants, pesticides, and metabolites of illicit and designer drugs. These molecules are more challenging to ionize and separate (i.e., resolve) using liquid chromatography mass spectrometry (LC-MS), and so are subjected to GC-MS instead.

GC-MS sample preparation can sometimes occur using LC-MS, as the following figure shows. Furthermore, advances in GC-MS technology, such as the introduction of the