A thermal cycler (also called thermocycler) is an instrument that employs precise temperature control and rapid temperature changes to conduct the polymerase chain reaction (PCR). PCR is used to create billions of copies of a DNA sequence for use in a wide array of downstream procedures including cloning, sequencing, expression analysis, and genotyping. Our engineers have been designing and manufacturing high-quality Applied Biosystems thermal cyclers since 1987; these instruments are renowned for their reliability, accuracy, and user-friendly interfaces.

Which thermal cycler is right for you?

  Most flexible and highest throughput
Elegant design, smart choice
For robust thermal cycling and diagnostic applications Designed for easy robotic integration
PCR System

Cloud enabled
SimpliAmp™ Thermal Cycler
Cloud enabled
Veriti™ Thermal Cycler** Automated Thermal Cycler (ATC)
Demo request

Demo request

Demo request

Demo request
Block formats
  • 3 x 32-well 0.2 mL independently controlled
  • 96-well 0.2 mL VeriFlex
  • 2 x 96-well 0.2 mL
  • 2 x flat block for digital applications
  • 2 x 384-well 0.02 mL
  • 96-well 0.2 mL
  • 96-well 0.2 mL
  • Fast 96-well 0.1 mL
  • 384-well 0.02 mL
  • 60-well 0.5 mL
  • 96-well, 0.2 mL block, compatible with full- or half-skirted plates
Temperature optimization
  • 6-zone VeriFlex Block on 96-well system
  • 2-zone VeriFlex Block on 32-well system
  • 3-zone VeriFlex Blocks on 96-well systems
  • 6-zone VeriFlex Blocks on 96-well systems
User interface 8.4 in. touch screen 8.4 in. touch screen 6.5 in. touch screen Automated via robotics; desktop software allows full integration
Up to 480,000 reactions Up to 96 reactions Up to 384 reactions Up to 96 reactions
Max block ramp rate*** 6.0°C/sec 4.0°C/sec 5.0°C/sec 3.5°C/sec
  Learn more Learn more Learn more Learn more

**Also available as an FDA Class 1/ CE-IVD labeled device, click here for details
***For information about how ramp rates are calculated, click here

History of PCR Infographic


Applied Biosystems Thermal Cycler, Plastics and Services Brochure

PCR and cDNA Synthesis Support Center 
Tips and troubleshooting help

School of Molecular Biology, PCR Education
Technical content for new and experienced molecular biologists

Thermal Cycler Software and Firmware Files
Download the latest updates for your instrument

Interested in private label thermal cyclers?
Submit an inquiry


We provide award-winning service options for all Applied Biosystems thermal cyclers.

Service plans

  • Rapid Exchange minimizes interruptions from unplanned instrument downtime
  • Global Repair Center provides a cost-efficient way to maximize uptime and achieve superior performance

Additional services available

Instrument qualification service: Have one of our engineers perform temperature qualifications at your site. You may also contact Instrument Services to purchase a temperature verification tool and perform the qualification yourself.