BiPhenyl Reversed Phase LC Columns

Having trouble resolving your compounds using your C18 column? The new Thermo Scientific Accucore Biphenyl LC column is your solution for:

  • Aromatic & moderately polar analytes
  • Drugs of abuse
  • Steroids

Now you can stop struggling with unresolved peaks, long run times, and poor lot-to-lot consistency. Obtain unique selectivity for aromatic and moderately polar analytes using Accucore Biphenyl LC Columns. These columns have optimized packing, offering a rugged platform for a variety of matrices.

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Accucore Biphenyl LC columns & benefits

  • Fast separations with excellent resolution and sensitivity
  • Lower backpressures so that UHPLC is not required
  • Mixed-mode selectivity for aromatic and moderately polar analytes
  • Enhanced π-π interactions with aromatics
  • Excellent lot-to-lot reproducibility
  • Great column lifetime
  • Compatibility with 100% aqueous conditions
  • A rugged column suitable for a variety of matrices

 

Catalog Description Diameter (metric) Length (metric) Particle size  
17826-052130 Accucore Biphenyl Analytical Column 2.1x50mm 2.1mm 50mm  2.6µm Order
17826-102130 Accucore Biphenyl Analytical Column 2.1x100mm 2.1mm 100mm  2.6µm Order
17826-012105 Accucore Defender Guard Cartridges 4/pk 2.1mm 10mm  2.6µm Order

When to use biphenyl selectivity?

Generally, C18 columns offer the ability to resolve a wide variety of analytes without issue. However, there are times when alternative chemistry is required for the separation of aromatic and moderately polar analytes. A biphenyl chemistry offers complementary selectivity to a C18 column, and the ability to resolve isomeric compounds, such as drugs of abuse and steroids by taking advantage of π-π interactions between the analyte and the stationary phase. This can help pull critical peaks out of matrix interferences.

When to use biphenyl selectivity?

Accucore biphenyl benefits

Our solid core column is designed based around voice of customer, addressing critical needs for customers in clinical research, forensic toxicology, pharmaceutical, and environmental labs. We have demonstrated outstanding column ruggedness and lot-to-lot reproducibility on this phase, optimizing critical parameters such as retention time stability, pressure, and peak asymmetry. Data quality should not be a concern.

We performed a ballistic gradient for over 3000 injections on an acidic, neutral, and basic compound. The data quality remained steady.

Why Accucore?

Further flexing its strength, the Accucore Biphenyl can separate a mix of steroid compounds in under 4 minutes, saving run time on instrumentation, and helping to improve sample throughput.

Delivering performance in assays where you need it most. Commonly used in clinical research labs for the separation of pain management compounds, the Accucore Biphenyl offers outstanding resolution of compounds such as codeine/hydrocodone and morphine/hydromorphone, while eluting metabolites of THC in under 4 minutes.
Delivering performance in assays where you need it most. Commonly used in clinical research labs for the separation of pain management compounds, the Accucore Biphenyl offers outstanding resolution of compounds such as codeine/hydrocodone and morphine/hydromorphone, while eluting metabolites of THC in under 4 minutes.
 Click to enlarge

When to use biphenyl selectivity?

Generally, C18 columns offer the ability to resolve a wide variety of analytes without issue. However, there are times when alternative chemistry is required for the separation of aromatic and moderately polar analytes. A biphenyl chemistry offers complementary selectivity to a C18 column, and the ability to resolve isomeric compounds, such as drugs of abuse and steroids by taking advantage of π-π interactions between the analyte and the stationary phase. This can help pull critical peaks out of matrix interferences.

When to use biphenyl selectivity?

Accucore biphenyl benefits

Our solid core column is designed based around voice of customer, addressing critical needs for customers in clinical research, forensic toxicology, pharmaceutical, and environmental labs. We have demonstrated outstanding column ruggedness and lot-to-lot reproducibility on this phase, optimizing critical parameters such as retention time stability, pressure, and peak asymmetry. Data quality should not be a concern.

We performed a ballistic gradient for over 3000 injections on an acidic, neutral, and basic compound. The data quality remained steady.

Why Accucore?

Further flexing its strength, the Accucore Biphenyl can separate a mix of steroid compounds in under 4 minutes, saving run time on instrumentation, and helping to improve sample throughput.

Delivering performance in assays where you need it most. Commonly used in clinical research labs for the separation of pain management compounds, the Accucore Biphenyl offers outstanding resolution of compounds such as codeine/hydrocodone and morphine/hydromorphone, while eluting metabolites of THC in under 4 minutes.
Delivering performance in assays where you need it most. Commonly used in clinical research labs for the separation of pain management compounds, the Accucore Biphenyl offers outstanding resolution of compounds such as codeine/hydrocodone and morphine/hydromorphone, while eluting metabolites of THC in under 4 minutes.
 Click to enlarge