(U)HPLC columns optimized for your analytical performance

Solve your separation challenges with our three premier brands of HPLC and UHPLC columns for small molecules. Our popular product lines of Hypersil GOLD, Accucore, and Acclaim columns are designed for a wide range of applications and offer the following features:

  • High-resolution, high-pressure HPLC and UHPLC columns
  • Built on a 40-year legacy of innovation
  • Unmatched variety of stationary phase chemistries, particle sizes, and column formats
  • Long column lifetime with reproducible results
  • The broadest assortment of solid core columns on the market

From the most commonly-used C18 phases, to innovative mixed-mode chemistries, we have the right column to fulfill your chromatography needs

Meet our (U)HPLC column families

Hypersil GOLD columns

Fully porous for simple samples

  • checkmarkFully porous, ultrapure silica particle columns
  • checkmarkBuilt on 40 years of experience in column development and manufacturing
  • checkmarkExcellent resolution, efficiency, and sensitivity for routine, high-quality separations
  • checkmarkFully scalable from UHPLC to prep

Accucore columns

Solid core for high resolution

  • checkmarkSolid core silica technology columns
  • checkmarkUHPLC efficiency on any instrument
  • checkmarkRapid, high-resolution separation of complex samples and limited sample volumes
  • checkmarkIncreased sensitivity and peak capacity using standard HPLC

Acclaim columns

Fully porous for complicated samples

Your first choice of (U)HPLC columns for general analyses

  • The go-to, easy-to-use HPLC columns for a variety of chromatographic separations
  • Built on 40 years of experience in column development and manufacturing
  • Available in a complete range of particle sizes, allowing for full scalability from UHPLC to prep – perform R&D on a high-resolution 1.9 µm column and transfer easily to QC and production
  • Outstanding peak shape for reversed phase, ion-exchange, HILIC, or normal phase chromatography
  • Excellent resolution, efficiency, and sensitivity
 Hypersil GOLD Overview

Explore our complete range of Hypersil GOLD columns to start your chromatography analyses

Hydrophobic Column Phases

Reversed phase chemistry for separation via hydrophobic interactions. Stationary phases with longer carbon chains provide longer retention times and greater hydrophobicity.


C18, C8, C4

Polar-Modified C18 Column Phases

Good for the separation of acidic and basic compounds via reversed phase chromatography using an aqueous mobile phase.


aQ

Phenyl-Based Column Phases

Orthogonal selectivity to traditional hydrophobic phases that utilizes aromatic interactions to achieve challenging separations of aromatic and polar compounds.

Phenyl, PFP

Ion-Exchange Column Phases

Ionic and polar compounds are retained via hydrophilic and ionic interactions with a charged stationary phase. Retained compounds can be eluted by changing the solvent conditions of the column.


Amino, Cyano

Hydrophilic Columns

Ideal for retaining and separating polar compounds based on polarity differences and affinity for a polar stationary phase.

HILIC, Silica

Phase Name

1.9 µm

3 µm

5 µm

Pore Size (Å)

Carbon Load (%)

Surface Area (m²/g)

USP

Hypersil GOLD C18

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175

10

220

L1

Hypersil GOLD C8

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175

8

220

L7

Hypersil GOLD C4

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175

5

220

L26

Hypersil GOLD aQ

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175

12

220

L1

Hypersil GOLD PFP

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175

8

220

L43

Hypersil GOLD Phenyl

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175

8

220

L11

Hypersil GOLD Amino

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175

2

220

L9

Hypersil GOLD Cyano

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175

4

220

L10

Hypersil GOLD HILIC

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175

6

220

Hypersil GOLD Silica

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175

220

L3

Learn more about Hypersil GOLD columns

Solid core silica particles for greater speed and resolution

  • High-resolution separation on rugged, solid core, superficially porous particles
  • Fast and easy analyses with a wide selection of chemistries
  • Increased sensitivity on a standard HPLC system
  • Compatible with almost any instrument
Accucore HPLC and UHPLC columns

Discover high-throughput columns for rapid (U)HPLC separations

Hydrophobic Column Phases

Reversed phase chemistry for separation via hydrophobic interactions. Stationary phases with longer carbon chains provide longer retention times and greater hydrophobicity.

C18, C8, C4

Specialty Hydrophobic Column PhasesAlternative selectivity to C18 for hydrophobic retention and the geometric separation of structural isomers.

RP-MS, C30
Phenyl-Based Column Phases

Orthogonal selectivity to traditional hydrophobic phases that utilizes aromatic interactions to achieve challenging separations of aromatic and polar compounds.

Biphenyl, Phenyl-Hexyl, PFP

Polar-Modified C18 Column Phases

Good for the separation of acidic and basic compounds via reversed phase chromatography using an aqueous mobile phase

Polar Premium, aQ

HILIC Column Phases

Ideal for retaining and separating polar compounds based on polarity differences and affinity for a polar stationary phase.

HILIC, Amide HILIC

Phase Name

1.5 μm

2.6 μm

4 μm

Pore Size (Å)

Surface Area (m²/g)

Carbon Load (%)

USP

Accucore C18

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80

130

9

L1

Accucore Vanquish C18+

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80

130

6.5

L1

Accucore XL C18

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80

130

7

L1

Accucore C8

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80

130

9

L7

Accucore XL C8

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80

130

4

L7

Accucore 150-C4

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150

80

2

L26

Accucore aQ

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80

130

9

L1

Accucore Polar Premium

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80

130

8

L60

Accucore RP-MS

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80

130

7

L1

Accucore C30

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80

130

5

L62

Accucore Biphenyl

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80

130

6

L11

Accucore Phenyl-Hexyl

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80

130

5

L11

Accucore PFP

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80

130

5

L43

Accucore Phenyl-X

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80

130

6

Accucore HILIC

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80

130

L3

Accucore 150-Amide-HILIC

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150

80

Accucore Urea HILIC

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80

130

Learn more about Accucore columns

Our broadest stationary phase variety for high-efficiency separations

  • The go-to column for complex mixtures that require greater resolution
  • More phases, more choices tailored to your analysis needs
  • Particles are fully porous with a high surface area, ensuring high sample retention
  • Designed for complicated samples
  • Separates and resolves compounds when other columns are not effective
Acclaim HPLC and UHPLC columns

Highly retentive columns in a wide range of selectivities

Reversed Phase Column Phases

Use to separate samples via hydrophobic interactions between solute molecules in the mobile phase and a hydrophobic stationary phase.

C18, C8, C30, Polar Advantage, Polar Advantage II
 

Mixed-Mode Column Phases

Separate polar, nonpolar, and ionizable compounds in a single analysis. Achieve baseline separation of challenging polar analytes without derivatizing.

Mixed-Mode WAX-1, Mixed-Mode WCX-1, Mixed-Mode HILIC-1, Trinity P1, Trinity P2, Trinity Q1

Application-Specific Column Phases

Unique stationary phases for specific applications such as the analysis of surfactants, organic acids, pesticides, aminoglycosides, or explosive residues.

Organic Acid, Surfactant Plus, AmG C18, Explosives E2, Carbamate, Carbonyl

HILIC Column Phases

Ideal for retaining and separating polar compounds based on polarity differences and affinity for a polar stationary phase.

HILIC-10

Phase Name

2.2 µm

3 µm

5 µm

7 µm

Pore Size (Å)

Surface Area (m²/g)

Carbon Load (%)

USP

Acclaim 120 C18

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120

300

18

L1

Acclaim 300 C18

 

300

100

8

L1

Acclaim Vanquish C18

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120

300

18

L1

Acclaim 120 C8

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120

300

11

L7

Acclaim Polar Advantage

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120

300

17

L60

Acclaim Polar Advantage II

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120

300

17

L60

Acclaim Vanquish Polar Advantage II

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120

300

17

L60

Acclaim C30

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200

200

13

L62

Acclaim Phenyl-1

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120

300

13

L11

Acclaim HILIC-10

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120

8

Acclaim Organic Acid

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120

300

17

Acclaim Surfactant

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120

300

12

Acclaim Surfactant Plus

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120

300

Acclaim Explosives E2

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120

300

Acclaim Carbamate

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120

300

Acclaim Carbonyl C18

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120

300

Acclaim Trinity Q1

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300

100

Acclaim AmG C18

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120

300

Acclaim Trinity P1

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300

100

Acclaim Trinity P2

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300

100

Acclaim Mixed-Mode WAX-1

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120

300

L85

Acclaim Mixed-Mode HILIC-1

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120

300

Acclaim Mixed-Mode WCX-1

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120

300

L78

Acclaim SEC-300

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300

L25

Learn more about Acclaim columns

HPLC column selection guide

 

* Required field

Style Sheet for Global Design System
CMD Wide-format style fixes
CMD SchemaApp code