Go beyond with Orbitrap Tribrid MS for large and small molecule analysis
Built on revolutionary Thermo Scientific Tribrid architecture that combines the best of quadrupole, Orbitrap, and linear ion trap mass analyzers, Orbitrap Tribrid mass spectrometers enable high throughput analyses of challenging samples.
These include accurate and precise quantitation of low-abundance peptides in complex matrices, characterization of structural isomers, from drug metabolites to intact proteins, resolution of isobaric species, and native protein complexes structure characterization.
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Look inside an Orbitrap Tribrid Mass Spectrometer
The architecture inside of an Orbitrap Tribrid mass spectrometer enables a broad range of experimental applications from discovery to profiling and quantification, expediting scientific advancements while offering experimental flexibility, all on a single instrument.
Explore our Orbitrap Tribrid instruments
Look inside the novel Orbitrap IQ-X Tribrid mass spectrometer.
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Orbitrap Ascend Tribrid MS
Scale up your science. With new capabilities for multiplexed quantitative proteomics and native protein characterization, the Thermo Scientific Orbitrap Ascend Tribrid mass spectrometer delivers ultimate experimental throughput, versatility, and ease-of-use. Quantify more samples at lower concentrations using intelligent acquisition and faster Real-Time Search. Achieve greater coverage using a revolutionary new hardware design featuring two ion routing multipoles. Or characterize the largest biopharmaceuticals with optional mass range up to m/z 16,000. All while producing more with less instrument setup featuring automated Auto-Ready ion source for calibration and pre-built, optimized method templates to maximize convenience and ease-of-use. Be ready for tomorrow’s most challenging demands
“One thing on the Orbitrap Ascend Tribrid MS that is really exciting is the new ion routing multiples, and how by moving the collision cell forward, the speed of the system has gotten even faster from the last model. That means that we can dig deeper in a sample, and we can detect more things in a shorter period of time”
Joshua Coon, PhD Principal Investigator, Coon Laboratories, University of Wisconsin-Madison
Dr. Erwin Schoof, Head of Proteomics Facility,
Technical University of Denmark Postdoctorial Fellow, Copenhagen University
Dr. Ryan Kelly, Associate professor
Chemistry and Biochemistry, Brigham Young University
Dr. Erwin Schoof, Head of Proteomics Facility,
Technical University of Denmark Postdoctorial Fellow, Copenhagen University
Dr. Ryan Kelly, Associate professor
Chemistry and Biochemistry, Brigham Young University
Orbitrap IQ-X Tribrid MS
Thermo Scientific Orbitrap IQ-X Tribrid Mass Spectrometer is our premier Orbitrap Tribrid MS dedicated to the analysis of small molecules. Utilizing multiple modes of fragmentation, intelligent data acquisition with AcquireX workflow, intelligent MSn powered by Real-Time Library Search, and annotation of unknowns with the mzLogic algorithm, it facilitates comprehensive structural characterization of unknowns in a wide variety of applications ranging from forensics to metabolomics.
Researchers across the globe are making use of the Thermo Scientific Orbitrap ID-X Tribrid mass spectrometer to study metabolic perturbations caused by Covid-19. Ivayla Roberts et al… uncovered a combination of metabolites that are prognostic markers of disease severity and whether the patient are likely to survive.
Dr. Sheng Zhang, Director
Proteomics Facility and Metabolomics Facility, Cornell University
Dr. Sheng Zhang, Director
Proteomics Facility and Metabolomics Facility, Cornell University
Orbitrap Fusion Lumos Tribrid MS
Thermo Scientific Orbitrap Fusion Lumos Tribrid mass spectrometer delivers unprecedented sensitivity, selectivity and versatility to enable life scientists to obtain high quality data. It is designed to pursue difficult analyses, including multiplexed quantitation of low-abundance peptides in complex matrices, characterization of positional isoforms of intact proteins, resolution of isobaric metabolites, protein structure characterization using chemical crosslinking and deep mining of challenging post-translational modifications.
Recently, the Orbitrap Fusion Lumos mass spectrometer was used to characterize DNA-protein crosslinking in Escherichia coli engineered to use methanol as a source of carbon. Researchers from UCLA showed that cultures inoculated from the stationary phase exhibited exceedingly long lag phases. Identification and quantification of DNA-crosslinked proteins provided insight on the possible causes of cell death and potential disruption to the transcription and translation processes that would explain this observation.
Orbitrap Fusion Tribrid MS
Dr. Pierre Thibault, Professor
Department of Chemistry, Faculty of Arts and Sciences, University of Montreal
Dr. Pierre Thibault, Professor
Department of Chemistry, Faculty of Arts and Sciences, University of Montreal
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