Go beyond with Orbitrap Tribrid MS for large and small molecule analysis

Go beyond with Orbitrap Tribrid MS for large and small molecule analysis

Built on revolutionary Thermo Scientific Tribrid architecture that combines the best of quadrupole, Orbitrap, and linear ion trap mass analyzers, Orbitrap Tribrid mass spectrometers enable high throughput analyses of challenging samples.

These include accurate and precise quantitation of low-abundance peptides in complex matrices, characterization of structural isomers, from drug metabolites to intact proteins, resolution of isobaric species, and native protein complexes structure characterization.

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Look inside an Orbitrap Tribrid Mass Spectrometer

The architecture inside of an Orbitrap Tribrid mass spectrometer enables a broad range of experimental applications from discovery to profiling and quantification, expediting scientific advancements while offering experimental flexibility, all on a single instrument.


Explore our Orbitrap Tribrid instruments


Orbitrap Ascend Tribrid MS

Scale up your science. With new capabilities for multiplexed quantitative proteomics and native protein characterization, the Thermo Scientific Orbitrap Ascend Tribrid mass spectrometer delivers ultimate experimental throughput, versatility, and ease-of-use. Quantify more samples at lower concentrations using intelligent acquisition and faster Real-Time Search. Achieve greater coverage using a revolutionary new hardware design featuring two ion routing multipoles. Or characterize the largest biopharmaceuticals with optional mass range up to m/z 16,000. All while producing more with less instrument setup featuring automated Auto-Ready ion source for calibration and pre-built, optimized method templates to maximize convenience and ease-of-use. Be ready for tomorrow’s most challenging demands

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“One thing on the Orbitrap Ascend Tribrid MS that is really exciting is the new ion routing multiples, and how by moving the collision cell forward, the speed of the system has gotten even faster from the last model. That means that we can dig deeper in a sample, and we can detect more things in a shorter period of time”

Joshua Coon, PhD Principal Investigator, Coon Laboratories, University of Wisconsin-Madison

Dr. Erwin Schoof
Multiplexing Single Cell Proteomics: A Marriage of Sensitivity and Throughput

Dr. Erwin Schoof, Head of Proteomics Facility,
Technical University of Denmark Postdoctorial Fellow, Copenhagen University

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Dr. Ryan Kelly
One Cell at a Time: Single Cell Proteomics Becomes a Reality

Dr. Ryan Kelly, Associate professor
Chemistry and Biochemistry, Brigham Young University

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Dr. Erwin Schoof
Multiplexing Single Cell Proteomics: A Marriage of Sensitivity and Throughput

Dr. Erwin Schoof, Head of Proteomics Facility,
Technical University of Denmark Postdoctorial Fellow, Copenhagen University

Watch webinar

Dr. Ryan Kelly
One Cell at a Time: Single Cell Proteomics Becomes a Reality

Dr. Ryan Kelly, Associate professor
Chemistry and Biochemistry, Brigham Young University

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Orbitrap IQ-X Tribrid MS


Orbitrap Fusion Lumos Tribrid MS


Orbitrap Fusion Tribrid MS



Boost selectivity and enhance your proteomics workflow with FAIMS Pro Interface

High-Field Asymmetric waveform Ion Mobility Spectrometry (FAIMS) can be used to optimize ion selectivity and reduce chemical backgrounds during mass spectrometry assays. FAIMS selectivity successfully prevents interferences from co-eluting compounds and increases signal to noise ratios by 100-fold or higher.

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