Go beyond with Orbitrap Tribrid MS for large and small molecule analysis

Tribrid Orbitrap-quadrupole-linear ion trap mass spectrometers for maximum research performance

Push the limits of complex large and small molecule analysis with our Orbitrap Tribrid mass spectrometers. They combine versatility, selectivity, sensitivity and speed to extend the limits of detection, characterization and quantitation. Equipped with a linear ion trap, a Thermo Scientific Orbitrap mass analyzer, and a quadrupole mass analyzer, they uniquely enable multiple sophisticated modes of analysis and experimental flexibility every day.

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Featured products

Orbitrap Eclipse Mass Spectrometer
Orbitrap ID-X™ Tribrid™ Mass Spectrometer
Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer

Which Orbitrap Tribrid mass spectrometer is best suited for your lab?

Orbitrap Tribrid mass spectrometers enable high throughput screening and characterization of challenging samples including low-abundance peptides in complex matrices, determination of positional and posttranslational isoforms of intact proteins, resolution of isobaric metabolites, and protein structure characterization using chemical crosslinking. The tribrid mass spectrometers excel at a broad range of experimental applications from discovery to profiling and quantification, expediting scientific advancements on a single instrument.

Our Orbitrap Tribrid systems vary in terms of mass resolution and analysis modes. To find the system best suited to your laboratory’s specific needs, refer to the chart below.

  Orbitrap ID-X Orbitrap Fusion Lumos Orbitrap Eclipse
  Orbitrap ID-X
Tribrid MS
Orbitrap Fusion Lumos
Tribrid MS
Orbitrap Eclipse Tribrid MS
Ideal Applications Small molecule characterization and elucidation research for applications such as Metabolomics, Drug development Met ID, Extactables and Leachables, Industrial Environmental Health and more Multi-omics, TMT, Intact/top-down proteomics, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking Multi-omics, TMT, Intact/top-down proteomics, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking, NativeOmics, LC-top-down mass spectrometry, Biotherapeutics
Analyses MS and MSn, Qualitative and Quantitative, Profiling, screening, and targeted
Advanced Data-Dependent Experiments Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, MSn Library builder SPS MS3, Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quanfirmation Acquisition, SureQuant RTS SPS MS3 ,Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quanfirmation Acquisition, SureQuant, Precursor FitFilter
AcquireX acquisition tool Requires Thermo Scientific Orbitrap Tribrid Series 4.2 SP1QF1 or greater
Almanac Web-Based Monitoring and Management Requires Foundation 3.1 SP1 or later
Standard Features
Resolution (FWHM) @ m/z 200 7,500-500,000 7,500-500,000 (1M optional)
Mass accuracy (internal calibration) <3 ppm (<1 ppm)
Mass range m/z 50-2,000 m/z 50-6,000 m/z 50 - 6,000 (up to 8000 with HMRn)
Scan rates (under defined conditions) 30 Hz (OT) 40 Hz (IT) 40 Hz (OT) 45 Hz (IT)
Scan Features Full scan, MS/MS, MSn, SIM, PRM, DIA, AIF Full scan, MS/MS, MSn, SIM, PRM, DIA, AIF, TurboTMT
Linear ion trap isolation 0.2 to 600 amu 0.2 to 4000 amu*
Optional Upgrades
UVPD laser No Yes
High Mass Rangen (HMRn), up to 8000 m/z No Yes
Proton Transfer Charged Reactions (PTCR) No Yes
1M Resolution No Yes
FAIMS Pro Interface No Yes


Orbitrap Tribrid mass spectrometers ordering guide

Boost selectivity and enhance your proteomics workflow with FAIMS Pro Interface

High-Field Asymmetric waveform Ion Mobility Spectrometry (FAIMS) can be used to optimize ion selectivity and reduce chemical backgrounds during mass spectrometry assays. FAIMS successfully prevents interferences from co-eluting compounds and increases signal to noise ratios by 100-fold or higher.

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The Orbitrap ID-X Tribrid mass spectrometer in combination with Compound Discoverer software, AcquireX and mzLogic offers a compelling solution for the pharmaceutical industry. Learn how to address your metabolite ID challenges.

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