Tribrid Orbitrap-quadrupole-linear ion trap mass spectrometers for maximum research performance
Push the limits of complex large and small molecule analysis with our Orbitrap Tribrid mass spectrometers. They combine versatility, selectivity, sensitivity and speed to extend the limits of detection, characterization and quantitation. Equipped with a linear ion trap, a Thermo Scientific Orbitrap mass analyzer, and a quadrupole mass analyzer, they uniquely enable multiple sophisticated modes of analysis and experimental flexibility every day.
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Which Orbitrap Tribrid mass spectrometer is best suited for your lab?
Orbitrap Tribrid mass spectrometers enable high throughput screening and characterization of challenging samples including low-abundance peptides in complex matrices, determination of positional and posttranslational isoforms of intact proteins, resolution of isobaric metabolites, and protein structure characterization using chemical crosslinking. The tribrid mass spectrometers excel at a broad range of experimental applications from discovery to profiling and quantification, expediting scientific advancements on a single instrument.
Our Orbitrap Tribrid systems vary in terms of mass resolution and analysis modes. To find the system best suited to your laboratory’s specific needs, refer to the chart below.
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| Orbitrap ID-X Tribrid MS |
Orbitrap Fusion Lumos Tribrid MS |
Orbitrap Eclipse Tribrid MS | |
|---|---|---|---|
| Ideal Applications | Small molecule characterization and elucidation research for applications such as Metabolomics, Drug development Met ID, Extactables and Leachables, Industrial Environmental Health and more | Multi-omics, TMT, Intact/top-down proteomics, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking | Multi-omics, TMT, Intact/top-down proteomics, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking, NativeOmics, LC-top-down mass spectrometry, Biotherapeutics |
| Analyses | MS and MSn, Qualitative and Quantitative, Profiling, screening, and targeted | ||
| Advanced Data-Dependent Experiments | Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, MSn Library builder | SPS MS3, Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quanfirmation Acquisition, SureQuant | RTS SPS MS3 ,Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quanfirmation Acquisition, SureQuant, Precursor FitFilter |
| AcquireX acquisition tool | Requires Thermo Scientific Orbitrap Tribrid Series 4.2 SP1QF1 or greater | ||
| Almanac Web-Based Monitoring and Management | Requires Foundation 3.1 SP1 or later | ||
| Standard Features | |||
| Resolution (FWHM) @ m/z 200 | 7,500-500,000 | 7,500-500,000 (1M optional) | |
| Mass accuracy (internal calibration) | <3 ppm (<1 ppm) | ||
| Mass range | m/z 50-2,000 | m/z 50-6,000 | m/z 50 - 6,000 (up to 8000 with HMRn) |
| Scan rates (under defined conditions) | 30 Hz (OT) 40 Hz (IT) | 40 Hz (OT) 45 Hz (IT) | |
| Scan Features | Full scan, MS/MS, MSn, SIM, PRM, DIA, AIF | Full scan, MS/MS, MSn, SIM, PRM, DIA, AIF, TurboTMT | |
| Linear ion trap isolation | 0.2 to 600 amu | 0.2 to 4000 amu* | |
| Optional Upgrades | |||
| ETD/EThcD | No | EASY-ETD | |
| UVPD laser | No | Yes | |
| High Mass Rangen (HMRn), up to 8000 m/z | No | Yes | |
| Proton Transfer Charged Reactions (PTCR) | No | Yes | |
| EASY-IC | Yes | ||
| 1M Resolution | No | Yes | |
| FAIMS Pro Interface | No | Yes | |
Orbitrap Tribrid mass spectrometers ordering guide
High-Field Asymmetric waveform Ion Mobility Spectrometry (FAIMS) can be used to optimize ion selectivity and reduce chemical backgrounds during mass spectrometry assays. FAIMS successfully prevents interferences from co-eluting compounds and increases signal to noise ratios by 100-fold or higher.
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Featured Orbitrap Tribrid mass spectrometers videos
The Orbitrap ID-X Tribrid mass spectrometer in combination with Compound Discoverer software, AcquireX and mzLogic offers a compelling solution for the pharmaceutical industry. Learn how to address your metabolite ID challenges.
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