BioProbes Journal of Cell Biology Applications

BioProbes Journal is a biannual publication that highlights a wide range of Thermo Scientific and Invitrogen cell biology products and applications. From new reagents and technologies to product reviews and online tools, we keep you up to date on the latest breakthroughs in cell and protein analysis.

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The Current Issue

Featured article

Amplify signals for fluorescence imaging: SuperBoost kits with Alexa Fluor tyramides for signal amplification.

Many functionally important proteins such as transcription factors and cell-surface cytokine receptors have native expression levels far below the detection threshold of labeled primary and secondary antibodies. The Invitrogen SuperBoost Kits with Alexa Fluor tyramides provide a highly sensitive method for detecting low-abundance targets in immunocytochemistry (ICC), immunohistochemistry (IHC), and in situ hybridization (ISH) applications. Tyramide SuperBoost technology combines the brightness of Alexa Fluor dyes with poly-HRP–mediated tyramide signal amplification to discern signal from noise, yielding precision and sensitivity 10–200 times greater than that of standard ICC/IHC/ISH methods and 2–10 times greater than that of other tyramide amplification techniques, including traditional TSA™ methods.

Resources

Fluorescence SpectraViewer

Compare multiple dyes and design and select a combination of cell structure probes

Molecular Probes Handbook

Comprehensive guide to fluorescent probes and labeling technologies