Identify small molecule substrates
ProtoArray Human Protein Microarrays are an excellent method to identify drug and small molecule substrates. Using this application, you can profile your radiolabeled, biotinylated, or fluorescently labeled molecule against 9,000 functional proteins and identify possible targets.
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Profile your radiolabeled, biotinylated, or fluorescently labeled small molecule against 9,000 functional proteins and identify possible targets with the ProtoArray protein microarray. Since the identity of every protein on the ProtoArray protein array is known, you can immediately identify any proteins that your molecule binds to. The protocol is straightforward, and can also be adapted to look at target competition using unlabeled competitor molecules to verify target specificity.
Collectively, these features make the ProtoArray Small Molecule Profiling application an ideal drug discovery tool for small molecules without clear modes of action. Researchers using the small molecule profiling application on the ProtoArray human microarrays have been able to identify drug targets and understand their mechanisms of action. See ProtoArray Literature Citations
The ProtoArray Small Molecule Profiling application is available either as a custom service or as a product.