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Nuclear Receptor Cell-Based Assays
Analyze compound efficacy as full or partial agonists or antagonists using cell lines validated by the Life Technology team of Nuclear Receptor experts.
Life Technology offers cell-based NR assays in two cell states:
Division Arrested, non-dividing cells, for “by the plate” assays Dividing Cells ideal for large screens.
See our validation data for a complete description of optimized assay conditions, DMSO tolerance, substrate loading time and pharmacology of know agonists and antagonists. See our customer protocol for a complete list of materials supplied and materials required but not supplied.
If you do not see the target or assay format of your choice please contact us.
Search Assays alphabetically
| Target and Alias(es) | Accession Number | Division Arrested Cat # | Dividing Cells Cat # | Validation Data | Customer Protocol | Available in SelectScreen® Service |
|---|---|---|---|---|---|---|
| AR (AR/NR3C4) | NP_036634 | K1698 |  | | X | |
| ER alpha (ERA/ESR1/NR3A1) | NP_000116 | K1393 | K1688 | | | X |
| ER beta (ERB/ESR2/NR3A2) | NP_001428 | K1399 | K1689B | | | X |
| ERR alpha (ERR1/ESRRA/NR3B1) | NP_004442 | K1421 | K1702 | | | X |
| FXR (NR1H4) | NP_005114.1 | K1397 | K1691 | | | X |
| GR (NR3C1) | NP_000167 | K1391 | K1687 | | | X |
| GR (NR3C1) | Full length Endogenous GR | K1641B | | | † | |
| LXR alpha (LXRA/N41H3) | NP_005684 | K1401 | K1692 | | | X |
| LXR beta (LXRB/NR1H2) | NP_009052 | K1415 | K1699 | | | X |
| MR (NR3C2) | K1409 | K1696 | | | X | |
| PPAR alpha (PPARA/NR1C1) | NP_005027 | K1875** | | | † | |
| PPAR delta (PPARD/NR1C2) | NP_006229 | K1395 | K1690 | | | X |
| PPAR gamma (PPARG/NR1C3) | NP_005028 | K1419 | K1701 | | | X |
| PR (PGR/NR3C3) | NP_000917 | K1403 | K1693 | | | X |
| RAR alpha (RARA/NR1B1) | NP_000955 | K1387 | K1685 | | | X |
| RAR beta (RARB/NR1B2) | NP_000956 | K1407 | K1695 | | | X |
| RAR gamma (RARG/NR1B3) | NP_000957 | K1559 | K1763 | | | X |
| RXR alpha (RXRA/NR2B1) | NP_002948.1 | K1411 | K1697 | | | X |
| RXR beta (RXRB/NR2B2) | NP_068811 | K1405 | K1694 | | | X |
| TR alpha (THRA/NR1A1) | NP_955366.1 | K1385 | K1684 | | | X |
| TR beta (THRB/NR1A2/T3RB) | NP_000452.2 | K1389 | K1686 | | | X |
| VDR (NR1I1) | NP_000367 | K1417 | K1700 | | | X |
* K1641 - endogenous cell line using MMTV-bla HeLa cell background
** K1875 - consumable cells, similar to division arrest cells, but transduced with BacMam reagent
† Available for profiling through custom services, for more information contact discoveryservices@invitrogen.com
For Research Use Only. Not for use in diagnostic procedures.