CellSensor Cell Lines utilize GeneBLAzer Technology to provide you with a reliable, rapid, and sensitive method of analyzing the intracellular status of a wide range of disease-relevant signal transduction pathways upon exposure to drug candidates or other stimuli. When the pathway is activated or inhibited, beta-lactamase reporter activity is modulated and can be measured quantitatively and selectively with the GeneBLAzer Loading Substrates.

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PathwayCell lineCat. No.Validated dataSelectScreen™ profiling
Anti-oxidant ResponseARE-bla HepG2K1633 available
aryl hydrocarbon receptorCYP1A1-bla LS-180K1678  
B cell receptorNFAT-bla RA-1K1490 available
C/EBPC/EBP-bla FreeStyle 293FK1634  
cAMP/PKACRE-bla JurkatK1635 available
cAMP/PKACRE-bla FreeStyle 293FK1636  
cAMP/PKACRE-bla HEK 293TK1540 available
cAMP/PKACRE-bla CHO-K1K1535  
Cell Cycle pRB-E2Fdhfr(E2F)-bla NIH3T3K1639B  
DNA damage/p53 Responsep53RE-bla HCT-116K1640 available
ER Stress ResponseESRE-bla HeLaK1817 available
Glucocorticoid ReceptorMMTV-bla HeLaK1641B available
Heat Shock ResponseHSE-bla HeLaK1813 available
HedgehogGli-bla 22Rv1K1838  
HedgehogGli-bla NIH3T3K1642B  
HypoxiaHRE-bla HCT116K1643  
HypoxiaHRE-bla ME-180K1644 available
Interleukin 1IL-1-bla ECV304K1645  
Interleukin 4/STAT6STAT6-bla RA1K1646 available
JAK/STATirf1-bla HELK1647 available
JAK/STATSIE-bla ME-180K1648 available
JAK/STATISRE-bla HEK 293TK1655 available
JAK/STATSIE-bla HEK 293TK1649B available
JAK/STATISRE-bla JurkatK1656 available
JAK/STAT (IFNg, IL-6/OSM)GAS-bla ME-180K1651B  
JAK/STAT (IFNg, IL-6/OSM)c-fos-bla ME-180K1650  
JAK/STAT (IFNy, IL-6/OSM)SIE-bla THP-1K1652B  
JAK/STAT (IL-2)irf1-bla CTLL-2K1653  
JAK/STAT (IL-3)irf-bla Ba/F3K1654  
JAK2/STAT5irf1-bla TF1K1657 available
MAPKc-fos-bla HEK 293TK1659B available
MAPKc-fos-bla ME-180K1650 available
MAPKAP-1-bla HEK 293TK1658  
MAPK/EGFR/Ras/RafAP1-bla ME-180K1661 available
MAPK/MEK/B-rafAP1-bla A375K1660 available
MycMyc-bla HCT-116K1467  
NFkBNFkB-bla THP-1K1662 available
NFkBNFkB-bla ME-180K1667 available
NFkBNFkB-bla JurkatK1666 available
NFkBNFkB-bla FreeStyle 293FK1663  
NFkBNFkB-bla HEK 293TK1664  
NFkBNFkB-bla RA1K1665  
NotchT-REx NICD-CSL-bla HeLaK1487  
PI3K/AKT/FOXO3TREx FOXO3-DBE-bla HeLaK1468 available
PI3K/AKT/mTORDBE-bla MDA-MB-468K1814  
PKC & Ca2+TrkA-NFAT-bla CHO-K1K1516 available
PKC & Ca2+TrkB-NFAT-bla CHO-K1K1491 available
PKC & Ca2+TrkC-NFAT-bla CHO-K1K1515 available
PKC and Ca2+NFAT-bla HEK293TK1538  
PKC and Ca2+NFAT-bla CHO-K1K1534  
PKC/Ca2+NFAT-bla JurkatK1671B available
T Cell ReceptorNFAT-bla JurkatK1671B available
TGF beta and BMPSBE-bla A375K1514  
TGF-betaSBE-bla HEK 293TK1550 available
TLR3 / TBK1 / IRF3ISRE-bla RA1K1674  
TNF alphaTNFa-bla THP-1K1672B  
TNF-alpha/JNKAP1-bla ME-180K1661 available
Toll-Like ReceptorNFkB-bla RAW264.7K1673  
Toll-Like Receptor (TLR4)NFkB-bla THP-1K1662 available
Wnt/Beta-CateninLEF/TCF-bla HCT-116K1676 available
Wnt/Beta-CateninLEF/TCF-bla FreeStyle 293FK1677  
Wnt/Beta-Catenin (APC-/-)LEF/TCF-bla SW 480K1675 available
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