Find out how crosslinkers are used in the literature

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Have you ever looked at our crosslinkers and wondered why you would crosslink your own biomolecules? Well, we reviewed the literature to identify recent papers in which the authors describe using our crosslinkers to answer biological questions using the following applications:

  • Interaction analysis—study signal transduction pathways using crosslinkers to trap, isolate and identify interactions between proteins, membrane receptors, peptides and nucleic acids
  • Conjugation—create custom conjugates by covalently linking biomolecules such as proteins, antibodies, enzymes, nucleic acids, drugs, peptides, hormones, metabolites and cellular organelles
  • Immobilization—immobilize antibodies and other proteins, nucleic acids, and cells onto resin, extracellular matrix (ECM), chips, slides, or nanoparticles
  • In vivo crosslinking—trap protein complexes in live cells by treating cells with crosslinking reagents
  • Labeling—tag proteins or nucleic acids with various reporters, such as fluorophores
  • Chromatin immunoprecipitation (ChIP)–isolate DNA binding complexes by crosslinking and immunoprecipitating DNA binding proteins
  • Structural analysis—study protein oligomerization or the formation of heterologous protein complexes by mapping binding sites
  • Antigen preparation—crosslink antigens to carrier proteins for animal immunization and antibody production
  • Protein alkylation—chemically block amino acid functional groups on proteins

 

Instructions

The interactive table below lists the applications, products, and references for the papers that we found to give you an idea of the scope of their use and spark your interest in using them to answer important research questions.

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Application Product name Catalog no. Reference
Small molecule-micelle conjugation DCC 20320 Chen H. et al. (2008) Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Forster resonance energy transfer imaging. Proc Natl Acad Sci U S A. 105, 6596-6601. PMID: 18445654
Small molecule-dendrimer conjugation KMUH 22111 Wu G.et al. . (2006) Targeted delivery of methotrexate to epidermal growth factor receptor-positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates. Mol Cancer Ther. 5, 52-59. PMID: 16432162
Protein-small molecule conjugation SMPT 21558 Austin C. D. et al. (2005) Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates. Proc Natl Acad Sci U S A. 102, 17987-17992. PMID: 16322102
Protein-small molecule conjugation SIA 22349 Chen Y. R. et al. (2004) Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical. J Biol Chem. 279, 18054-18062. PMID: 14761966
Protein-small molecule conjugation SMPT 21558 Windt W. A.et al. (2004) Renal targeting of captopril using captopril-lysozyme conjugate enhances its antiproteinuric effect in adriamycin-induced nephrosis. J Renin Angiotensin Aldosterone Syst. 5, 197-202. PMID: 15803438
Protein-protein interaction analysis ANB-NOS 21451 Adams C. A.et al. (2004) Self-association of the amino-terminal domain of the yeast TATA-binding protein. J Biol Chem. 279, 1376-1382. PMID: 14534318
Protein-protein interaction analysis EMCS 22308 Akin B. L. and Jones L. R. (2012) Characterizing phospholamban to sarco(endo)plasmic reticulum Ca2+-ATPase 2a (SERCA2a) protein binding interactions in human cardiac sarcoplasmic reticulum vesicles using chemical cross-linking. J Biol Chem. 287, 7582-7593. PMID: 22247554
Protein-protein interaction analysis KMUS   Chen Z. et al. (2003) Spatial and dynamic interactions between phospholamban and the canine cardiac Ca2+ pump revealed with use of heterobifunctional cross-linking agents. J Biol Chem. 278, 48348-48356. PMID: 12972413
Protein-protein interaction analysis AMAS 22295 Chen Z. et al. (2003) Spatial and dynamic interactions between phospholamban and the canine cardiac Ca2+ pump revealed with use of heterobifunctional cross-linking agents. J Biol Chem. 278, 48348-48356. PMID: 12972413
Protein-protein interaction analysis BMPS 22298 Chen Z. et al. (2003) Spatial and dynamic interactions between phospholamban and the canine cardiac Ca2+ pump revealed with use of heterobifunctional cross-linking agents. J Biol Chem. 278, 48348-48356. PMID: 12972413
Protein-protein interaction analysis EMCS 22308 Chen Z. et al. (2003) Spatial and dynamic interactions between phospholamban and the canine cardiac Ca2+ pump revealed with use of heterobifunctional cross-linking agents. J Biol Chem. 278, 48348-48356. PMID: 12972413
Protein-protein interaction analysis MBS 22311 Chen Z. et al. (2003) Spatial and dynamic interactions between phospholamban and the canine cardiac Ca2+ pump revealed with use of heterobifunctional cross-linking agents. J Biol Chem. 278, 48348-48356. PMID: 12972413
Protein-protein interaction analysis SMCC 22360 Chen Z. et al. (2003) Spatial and dynamic interactions between phospholamban and the canine cardiac Ca2+ pump revealed with use of heterobifunctional cross-linking agents. J Biol Chem. 278, 48348-48356. PMID: 12972413
Protein-protein interaction analysis SMPH 22363 Chen Z.et al. (2003) Spatial and dynamic interactions between phospholamban and the canine cardiac Ca2+ pump revealed with use of heterobifunctional cross-linking agents. J Biol Chem. 278, 48348-48356. PMID: 12972413
Protein-protein interaction analysis EMCS 22308 Chen Z. et al. (2005) Role of leucine 31 of phospholamban in structural and functional interactions with the Ca2+ pump of cardiac sarcoplasmic reticulum. J Biol Chem. 280, 10530-10539. PMID: 15644311
Protein-protein interaction analysis KMUS   Chen Z. et al. (2007) Mechanism of reversal of phospholamban inhibition of the cardiac Ca2+-ATPase by protein kinase A and by anti-phospholamban monoclonal antibody 2D12. J Biol Chem. 282, 20968-20976. PMID: 17548345
Protein-protein interaction analysis EMCS 22308 Chen Z. et al. (2007) Mechanism of reversal of phospholamban inhibition of the cardiac Ca2+-ATPase by protein kinase A and by anti-phospholamban monoclonal antibody 2D12. J Biol Chem. 282, 20968-20976. PMID: 17548345
Protein-protein interaction analysis Sulfo-SBED Biotin 33033, 33034, 33073 Emara M.et al. (2012) Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite. J Biol Chem. 287, 5756-5763. PMID: 22205703
Protein-protein interaction analysis Sulfo-SBED Biotin 33033, 33034, 33073 Emara M. et al. (2012) Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite. J Biol Chem. 287, 5756-5763. PMID: 22205703
Protein-protein interaction analysis DSP 22585, 22586 Gavazzi F. et al. (2007) Wild-type opaque2 and defective opaque2 polypeptides form complexes in maize endosperm cells and bind the opaque2-zein target site. Plant Physiol. 145, 933-45. PMID: 17827273
Protein-protein interaction analysis BMDB 22332 Gavazzi F.et al. (2007) Wild-type opaque2 and defective opaque2 polypeptides form complexes in maize endosperm cells and bind the opaque2-zein target site. Plant Physiol. 145, 933-945. PMID: 17827273
Protein-protein interaction analysis ANB-NOS 21451 Gorna M. W.et al. (2010) The regulatory protein RraA modulates RNA-binding and helicase activities of the E. coli RNA degradosome. RNA. 16, 553-562. PMID: 20106955
Protein-protein interaction analysis DFDNB 21525 Gruschke S. et al. (2010) Proteins at the polypeptide tunnel exit of the yeast mitochondrial ribosome. J Biol Chem. 285, 19022-19028. PMID: 20404317
Protein-protein interaction analysis DTSSP 21578 Hung C. W.et al. (2012) Adaptor autoregulation promotes coordinated binding within clathrin coats. J Biol Chem. 287, 17398-17407. PMID: 22457357
Protein-protein interaction analysis LC-SPDP 21651 Janganan T. K. et al. (2011) Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3. J Biol Chem. 286, 26900-26912. PMID: 21610073
Protein-protein interaction analysis SPDP 21857 Janganan T. K. et al. (2011) Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3. J Biol Chem. 286, 26900-26912. PMID: 21610073
Protein-protein interaction analysis DSS 21555, 21655, 21658 Jennebach S. et al. (2012) Crosslinking-MS analysis reveals RNA polymerase I domain architecture and basis of rRNA cleavage. Nucleic Acids Res. 40, 5591-5601. PMID: 22396529
Protein-protein interaction analysis L-Photo-Leucine or L-Photo-Methionine 22610, 22615, 30030 Jumper C. C. and Schriemer D. C. (2011) Mass spectrometry of laser-initiated carbene reactions for protein topographic analysis. Anal Chem. 83, 2913-2920. PMID: 21425771
Protein-protein interaction analysis BMOE 22323 Kida Y. et al. (2007) Two translocating hydrophilic segments of a nascent chain span the ER membrane during multispanning protein topogenesis. J Cell Biol. 179, 1441-1452. PMID: 18166653
Protein-protein interaction analysis BMH 22330 Kida Y. et al. (2007) Two translocating hydrophilic segments of a nascent chain span the ER membrane during multispanning protein topogenesis. J Cell Biol. 179, 1441-1452. PMID: 18166653
Protein-protein interaction analysis BMB 22331 Kida Y.et al. (2007) Two translocating hydrophilic segments of a nascent chain span the ER membrane during multispanning protein topogenesis. J Cell Biol. 179, 1441-1452. PMID: 18166653
Protein-protein interaction analysis BM(PEG)2 22336 Kida Y. et al. (2007) Two translocating hydrophilic segments of a nascent chain span the ER membrane during multispanning protein topogenesis. J Cell Biol. 179, 1441-1452. PMID: 18166653
Protein-protein interaction analysis Mts-Atf-Biotin Label Transfer Reagents 33083, 33093 Layer G. et al. (2007) SufE transfers sulfur from SufS to SufB for iron-sulfur cluster assembly. J Biol Chem. 282, 13342-13350. PMID: 17350958
Protein-protein interaction analysis DTSSP 21578 Li H. and Pauza C. D. (2011) HIV envelope-mediated, CCR5/alpha4beta7-dependent killing of CD4-negative gammadelta T cells which are lost during progression to AIDS. Blood. 118, 5824-5831. PMID: 21926353
Protein-protein interaction analysis DTSSP 21578 Liu H. et al. (2011) Psb27, a transiently associated protein, binds to the chlorophyll binding protein CP43 in photosystem II assembly intermediates. Proc Natl Acad Sci U S A. 108, 18536-18541. PMID: 22031695
Protein-protein interaction analysis Sulfo-SBED Biotin 33033, 33034, 33073 Loers G. et al. (2012) The interaction between cell adhesion molecule L1, matrix metalloproteinase 14, and adenine nucleotide translocator at the plasma membrane regulates L1-mediated neurite outgrowth of murine cerebellar neurons. J Neurosci. 32, 3917-3930. PMID: 22423112
Protein-protein interaction analysis DFDNB 21525 Lucker B. F. et al. (2010) Direct interactions of intraflagellar transport complex B proteins IFT88, IFT52, and IFT46. J Biol Chem. 285, 21508-21518. PMID: 20435895
Protein-protein interaction analysis LC-SMCC 22362 Nguyen M. et al. (2007) Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 104, 19512-19517. PMID: 18040043
Protein-protein interaction analysis Mts-Atf-Biotin Label Transfer Reagents 33083, 33093 Padrick S. B. et al. (2011) Arp2/3 complex is bound and activated by two WASP proteins. Proc Natl Acad Sci U S A. 108, E472-479. PMID: 21676863
Protein-protein interaction analysis AMAS 22295 Pech M. et al. (2010) Dual binding mode of the nascent polypeptide-associated complex reveals a novel universal adapter site on the ribosome. J Biol Chem. 285, 19679-19687. PMID: 20410297
Protein-protein interaction analysis BS(PEG)5, BS(PEG)9 21581, 21582 Petrie R. J. et al. (2012) Nonpolarized signaling reveals two distinct modes of 3D cell migration. J Cell Biol. 197, 439-455. PMID: 22547408
Protein-protein interaction analysis DFDNB 21525 Schulz C. et al. (2011) Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex. J Cell Biol. 195, 643-656. PMID: 22065641
Protein-protein interaction analysis DTBP 20665 Shi Y. et al. (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell. 22, 4093-4107. PMID: 21880895
Protein-protein interaction analysis SIAB 22329 Stan T. et al. (2003) Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complex. Mol Cell Biol. 23, 2239-2250. PMID: 12640110
Protein-protein interaction analysis Mts-Atf-Biotin Label Transfer Reagents 33083, 33093 Watzlich D. et al. (2009) Chimeric nitrogenase-like enzymes of (bacterio)chlorophyll biosynthesis. J Biol Chem. 284, 15530-15540. PMID: 19336405
Protein-protein interaction analysis DSS 21555, 21655, 21658 Yao Y. et al. (2012) Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood. 119, 5037-5047. PMID: 22474252
Protein-protein interaction analysis DTME 22335 Zhang H. et al. (2010) The extreme C terminus of the ABC protein DrrA contains unique motifs involved in function and assembly of the DrrAB complex. J Biol Chem. 285, 38324-38336. PMID: 20876527
Protein-protein conjugate formation PDPH 22301 Backman C. et al. (1996) Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy. J Neurosci. 16, 5437-5442. PMID: 8757256
Protein-protein conjugate formation BMDB 22332 Batra-Safferling R. et al. (2006) Glutamic acid-rich proteins of rod photoreceptors are natively unfolded. J Biol Chem. 281, 1449-1460. PMID: 16280326
Protein-protein conjugate formation MPBH 22305 Chamow S. M. et al. (1992) Conjugation of soluble CD4 without loss of biological activity via a novel carbohydrate-directed cross-linking reagent. J Biol Chem. 267, 15916-15922. PMID: 1639820
Protein-protein conjugate formation SMPT 21558 Ding B. S. et al. (2003) Lung endothelium targeting for pulmonary embolism thrombolysis. Circulation. 108, 2892-2898. PMID: 14610017
Protein-protein conjugate formation Sulfo-SMCC 22122, 22322, 22622 Harvey S. et al. (1998) Chondrex: new marker of joint disease. Clin Chem. 44, 509-516. PMID: 9510855
Protein-protein conjugate formation EMCH 22106 Joyce J. et al. (2006) Immunogenicity and protective efficacy of Bacillus anthracis poly-gamma-D-glutamic acid capsule covalently coupled to a protein carrier using a novel triazine-based conjugation strategy. J Biol Chem. 281, 4831-4843. PMID: 16293624
Protein-protein conjugate formation SPDP 21857 Karumuthil-Melethil S. et al. (2010) Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1 diabetes. J Immunol. 184, 6695-6708. PMID: 20483724
Protein-protein conjugate formation SMPB 22416 Karumuthil-Melethil S. et al. (2010) Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1 diabetes. J Immunol. 184, 6695-6708. PMID: 20483724
Protein-protein conjugate formation BS3 21580, 21585, 21586 Kilkenny M. L. et al. (2012) A conserved motif in the C-terminal tail of DNA polymerase alpha tethers primase to the eukaryotic replisome. J Biol Chem. 287, 23740-23747. PMID: 22593576
Protein-protein conjugate formation ANB-NOS 21451 Koulov A. V. et al. (2010) Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis. Mol Biol Cell. 21, 871-884. PMID: 20089831
Protein-protein conjugate formation SPDP 21857 Pallaoro A. et al. (2011) Quantitative ratiometric discrimination between noncancerous and cancerous prostate cells based on neuropilin-1 overexpression. Proc Natl Acad Sci U S A. 108, 16559-16564. PMID: 21930955
Protein-protein conjugate formation ANB-NOS 21451 Park B. and Ahn K. (2003) An essential function of tapasin in quality control of HLA-G molecules. J Biol Chem. 278, 14337-14345. PMID: 12582157
Protein-protein conjugate formation Sulfo-SMCC 22122, 22322, 22622 Percy A. J. et al. (1996) Development of sensitive immunoassays to detect amylin and amylin-like peptides in unextracted plasma. Clin Chem. 42, 576-585. PMID: 8605675
Protein-protein conjugate formation BS3 21580, 21585, 21586 Richter C. et al. (2012) The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand. Mol Cell Biol. 32, 2515-2529. PMID: 22547679
Protein-protein conjugate formation SMPH 22363 Schmitz N. et al. (2009) Displaying Fel d1 on virus-like particles prevents reactogenicity despite greatly enhanced immunogenicity: a novel therapy for cat allergy. J Exp Med. 206, 1941-1955. PMID: 19667059
Protein-protein conjugate formation SMPT 21558 Solomon S. R. et al. (2005) Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation. Blood. 106, 1123-1129. PMID: 15817673
Protein-protein conjugate formation SPDP 21857 You H. et al. (2012) Winding single-molecule double-stranded DNA on a nanometer-sized reel. Nucleic Acids Res. PMID: 22772992
Protein-nucleic acid interaction analysis Sulfo-GMBS 22324 Sheridan J. T. et al. (2011) Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A. J Biol Chem. 286, 1381-1388. PMID: 21056985
Protein-nucleic acid conjugation SMPB 22416 Meng F. and Sachs F. (2011) Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor. J Cell Sci. 124, 261-269. PMID: 21172803
Protein-nucleic acid conjugation Sulfo-SMPB 22317 Niemeyer C. M. et al. (2003) Combination of DNA-directed immobilization and immuno-PCR: very sensitive antigen detection by means of self-assembled DNA-protein conjugates. Nucleic Acids Res. 31, e90. PMID: 12907742
Protein-nucleic acid conjugation SMCC 22360 Obara K. et al. (2001) Protein/oligonucleotide conjugates as a cell specific PNA carrier. Nucleic Acids Res Suppl, 217-218. PMID: 12836342
Protein-membrane protein interaction analysis DSG 20593 Akin B. L. and Jones L. R. (2012) Characterizing phospholamban to sarco(endo)plasmic reticulum Ca2+-ATPase 2a (SERCA2a) protein binding interactions in human cardiac sarcoplasmic reticulum vesicles using chemical cross-linking. J Biol Chem. 287, 7582-93. PMID: 22247554
Protein-membrane protein interaction analysis KMUS   Akin B. L. et al. (2010) Superinhibitory phospholamban mutants compete with Ca2+ for binding to SERCA2a by stabilizing a unique nucleotide-dependent conformational state. J Biol Chem. 285, 28540-28552. PMID: 20622261
Protein-membrane protein interaction analysis DTSSP 21578 Boleij A. et al. (2011) Surface-affinity profiling to identify host-pathogen interactions. Infect Immun. 79, 4777-4783. PMID: 21947776
Protein-membrane protein interaction analysis DMS 20700 Chang T. W. et al. (2012) Outer membrane lipoprotein Lpp is Gram-negative bacterial cell surface receptor for cationic antimicrobial peptides. J Biol Chem. 287, 418-428. PMID: 22084237
Protein-membrane protein interaction analysis KMUS   Chen Z. et al. (2005) Role of leucine 31 of phospholamban in structural and functional interactions with the Ca2+ pump of cardiac sarcoplasmic reticulum. J Biol Chem. 280, 10530-10539. PMID: 15644311
Protein-membrane protein interaction analysis KMUS   Chen Z. et al. (2010) Ca2+ binding to site I of the cardiac Ca2+ pump is sufficient to dissociate phospholamban. J Biol Chem. 285, 3253-3260. PMID: 19948724
Protein-membrane protein interaction analysis Sulfo-EGS 21566 Deiss K. et al. (2012) Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2. J Biol Chem. 287, 23407-23417. PMID: 22610096
Protein-membrane protein interaction analysis DMA 20660 Fenton R. A. et al. (2007) Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney. Am J Physiol Renal Physiol. 293, F748-760. PMID: 17553938
Protein-membrane protein interaction analysis BSOCOES 21600 Fenton R. A. et al. (2007) Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney. Am J Physiol Renal Physiol. 293, F748-760. PMID: 17553938
Protein-membrane protein interaction analysis DMP 21666, 21667 Fenton R. A. et al. (2007) Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney. Am J Physiol Renal Physiol. 293, F748-760. PMID: 17553938
Protein-membrane protein interaction analysis BSOCOES 21600 Grinberg M. et al. (2005) Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol Cell Biol. 25, 4579-4590. PMID: 15899861
Protein-membrane protein interaction analysis Sulfo-NHS 24510, 24520, 24525 Ido K. et al. (2012) The conserved His-144 in the PsbP protein is important for the interaction between the PsbP N-terminus and the Cyt b559 subunit of photosystem II. J Biol Chem. 287, 26377-26387. PMID: 22707728
Protein-membrane protein interaction analysis EDC 77149, 22980, 22981 Ido K. et al. (2012) The conserved His-144 in the PsbP protein is important for the interaction between the PsbP N-terminus and the Cyt b559 subunit of photosystem II. J Biol Chem. 287, 26377-26387. PMID: 22707728
Protein-membrane protein interaction analysis LC-SPDP 21651 Lobedanz S. et al. (2007) A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps. Proc Natl Acad Sci U S A. 104, 4612-4617. PMID: 17360572
Protein-membrane protein interaction analysis SPDP 21857 Lobedanz S. et al. (2007) A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps. Proc Natl Acad Sci U S A. 104, 4612-4617. PMID: 17360572
Protein-membrane protein interaction analysis Sulfo-SMCC 22122, 22322, 22622 Mamedova A. A. et al. (2004) Substrate-induced conformational change in bacterial complex I. J Biol Chem. 279, 23830-23836. PMID: 15037611
Protein-membrane protein interaction analysis Sulfo-SMPB 22317 Mamedova A. A. et al. (2004) Substrate-induced conformational change in bacterial complex I. J Biol Chem. 279, 23830-23836. PMID: 15037611
Protein-membrane protein interaction analysis Sulfo-EGS 21566 Moore B. et al. (2011) Structural basis of molecular recognition of the Leishmania small hydrophilic endoplasmic reticulum-associated protein (SHERP) at membrane surfaces. J Biol Chem. 286, 9246-9256. PMID: 21106528
Protein-membrane protein interaction analysis Sulfo-SBED Biotin 33033, 33034, 33073 Moore B. et al. (2011) Structural basis of molecular recognition of the Leishmania small hydrophilic endoplasmic reticulum-associated protein (SHERP) at membrane surfaces. J Biol Chem. 286, 9246-9256. PMID: 21106528
Protein-membrane protein interaction analysis BS3 21580, 21585, 21586 Ohnishi H. et al. (2012) Identification of mannose receptor as receptor for hepatocyte growth factor beta-chain: novel ligand-receptor pathway for enhancing macrophage phagocytosis. J Biol Chem. 287, 13371-13381. PMID: 22354962
Protein-membrane protein interaction analysis Sulfo-EGS 21566 Ozvegy-Laczka C. et al. (2008) Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter. J Biol Chem. 283, 26059-26070. PMID: 18644784
Protein-membrane protein interaction analysis BMPH 22297 Ozvegy-Laczka C. et al. (2008) Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter. J Biol Chem. 283, 26059-26070. PMID: 18644784
Protein-membrane protein interaction analysis Sulfo-MBS 22312 Ozvegy-Laczka C. et al. (2008) Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter. J Biol Chem. 283, 26059-26070. PMID: 18644784
Protein-membrane protein interaction analysis PMPI 28100 Ozvegy-Laczka C. et al. (2008) Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter. J Biol Chem. 283, 26059-26070. PMID: 18644784
Protein-membrane protein interaction analysis BMDB 22332 Steiner H. et al. (2008) Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1. J Biol Chem. 283, 34677-34686. PMID: 18801744
Protein-membrane protein interaction analysis DSP 22585, 22586 Steiner H. et al. (2008) Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1. J Biol Chem. 283, 34677-34686. PMID: 18801744
Protein-membrane protein interaction analysis LC-SPDP 21651 Symmons M. F. et al. (2009) The assembled structure of a complete tripartite bacterial multidrug efflux pump. Proc Natl Acad Sci U S A. 106, 7173-7178. PMID: 19342493
Protein-membrane protein interaction analysis L-Photo-Leucine or L-Photo-Methionine 22610, 22615, 30030 Weaver M. S. et al. (2008) The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase. J Biol Chem. 283, 22826-22837. PMID: 18503049
Protein-membrane protein interaction analysis Sulfo-KMUS 21111 Weber A. N. et al. (2005) Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway. J Biol Chem. 280, 22793-22799. PMID: 15795223
Protein-membrane protein interaction analysis Sulfo-GMBS 22324 Weber A. N. et al. (2005) Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway. J Biol Chem. 280, 22793-22799. PMID: 15795223
Protein-membrane protein interaction analysis L-Photo-Leucine or L-Photo-Methionine 22610, 22615, 30030 Zhao W. Q. et al. (2010) Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. J Biol Chem. 285, 7619-7632. PMID: 20032460
Protein-membrane protein interaction analysis L-Photo-Leucine or L-Photo-Methionine 22610, 22615, 30030 Zhao W. Q. et al. (2010) Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. J Biol Chem. 285, 7619-7632. PMID: 20032460
Protein-membrane protein interaction analysis Sulfo-SMPB 22317 Zhu J. X. et al. (2005) Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. J Biol Chem. 280, 32468-32479. PMID: 15994311
Protein oligomerization DSS 21555, 21655, 21658 Ahmad R. et al. (2012) The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function. J Biol Chem. 287, 20866-20875. PMID: 22544745
Protein oligomerization DST 20589 Alian A. et al. (2009) Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs. Proc Natl Acad Sci U S A. 106, 8192-8197. PMID: 19416821
Protein oligomerization BS3 21580, 21585, 21586 Aryal R. P. et al. (2012) Tight complex formation between Cosmc chaperone and its specific client non-native T-synthase leads to enzyme activity and client-driven dissociation. J Biol Chem. 287, 15317-15329. PMID: 22416136
Protein oligomerization BMOE 22323 Auclair J. R. et al. (2010) Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 107, 21394-21399. PMID: 21098299
Protein oligomerization BMOE 22323 Auclair J. R. et al. (2010) Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 107, 21394-21399. PMID: 21098299
Protein oligomerization BMOE 22323 Auclair J. R. et al. (2010) Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 107, 21394-21399. PMID: 21098299
Protein oligomerization BMB 22331 Auclair J. R. et al. (2010) Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 107, 21394-21399. PMID: 21098299
Protein oligomerization BMDB 22332 Auclair J. R. et al. (2010) Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 107, 21394-21399. PMID: 21098299
Protein oligomerization DTME 22335 Auclair J. R. et al. (2010) Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 107, 21394-21399. PMID: 21098299
Protein oligomerization BM(PEG)2 22336 Auclair J. R. et al. (2010) Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 107, 21394-21399. PMID: 21098299
Protein oligomerization BM(PEG)2 22336 Auclair J. R. et al. (2010) Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 107, 21394-21399. PMID: 21098299
Protein oligomerization TMEA 33043 Auclair J. R. et al. (2010) Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 107, 21394-21399. PMID: 21098299
Protein oligomerization BMH 22330 Beck R. et al. (2008) Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Proc Natl Acad Sci U S A. 105, 11731-11736. PMID: 18689681
Protein oligomerization Sulfo-EGS 21566 Deiss K. et al. (2012) Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2. J Biol Chem. 287, 23407-23417. PMID: 22610096
Protein oligomerization Sulfo-KMUS 21111 Faye A. et al. (2007) Rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane. J Biol Chem. 282, 26908-26916. PMID: 17650509
Protein oligomerization DSS 21555, 21655, 21658 Faye A. et al. (2007) Rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane. J Biol Chem. 282, 26908-26916. PMID: 17650509
Protein oligomerization Sulfo-MBS 22312 Faye A. et al. (2007) Rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane. J Biol Chem. 282, 26908-26916. PMID: 17650509
Protein oligomerization Sulfo-GMBS 22324 Faye A. et al. (2007) Rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane. J Biol Chem. 282, 26908-26916. PMID: 17650509
Protein oligomerization DTSSP 21578 Fenyk S. et al. (2012) A nucleotide phosphatase activity in the nucleotide binding domain of an orphan resistance protein from rice. J Biol Chem. 287, 4023-4032. PMID: 22157756
Protein oligomerization DFDNB 21525 Geula S. et al. (2012) Structure-based analysis of VDAC1 protein: defining oligomer contact sites. J Biol Chem. 287, 2179-2190. PMID: 22117062
Protein oligomerization EGS 21565 Gogada R. et al. (2011) Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. J Biol Chem. 286, 28749-28760. PMID: 21712378
Protein oligomerization BMH 22330 Gogada R. et al. (2011) Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. J Biol Chem. 286, 28749-28760. PMID: 21712378
Protein oligomerization Sulfo-SMPB 22317 Goldoni S. et al. (2004) Biologically active decorin is a monomer in solution. J Biol Chem. 279, 6606-6612. PMID: 14660661
Protein oligomerization TMEA 33043 Gosink K. K. et al. (2011) Mutational analysis of N381, a key trimer contact residue in Tsr, the Escherichia coli serine chemoreceptor. J Bacteriol. 193, 6452-6460. PMID: 21965562
Protein oligomerization BMPH 22297 Ishmael S. S. et al. (2006) Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer. J Biol Chem. 281, 37404-37415. PMID: 17040911
Protein oligomerization Sulfo-EGS 21566 Jansma A. L. et al. (2010) NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27. J Biol Chem. 285, 14424-14437. PMID: 20200157
Protein oligomerization DMS 20700 Jha B. K. et al. (2011) Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity. J Biol Chem. 286, 26319-26326. PMID: 21636578
Protein oligomerization DFDNB 21525 Keinan N. et al. (2010) Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis. Mol Cell Biol. 30, 5698-5709. PMID: 20937774
Protein oligomerization EGS 21565 Keinan N. et al. (2010) Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis. Mol Cell Biol. 30, 5698-5709. PMID: 20937774
Protein oligomerization Sulfo-EGS 21566 Kim J. et al. (2011) Role of TRIM5alpha RING domain E3 ubiquitin ligase activity in capsid disassembly, reverse transcription blockade, and restriction of simian immunodeficiency virus. J Virol. 85, 8116-8132. PMID: 21680520
Protein oligomerization DMA 20660 Korczynska J. E. et al. (2012) The structural characterization of a prophage-encoded extracellular DNase from Streptococcus pyogenes. Nucleic Acids Res. 40, 928-938. PMID: 21948797
Protein oligomerization DMS 20700 Korczynska J. E. et al. (2012) The structural characterization of a prophage-encoded extracellular DNase from Streptococcus pyogenes. Nucleic Acids Res. 40, 928-938. PMID: 21948797
Protein oligomerization BS3 21580, 21585, 21586 Lay F. T. et al. (2012) Dimerization of plant defensin NaD1 enhances its antifungal activity. J Biol Chem. 287, 19961-19972. PMID: 22511788
Protein oligomerization BS(PEG)5, BS(PEG)9 21581, 21582 Lay F. T. et al. (2012) Dimerization of plant defensin NaD1 enhances its antifungal activity. J Biol Chem. 287, 19961-19972. PMID: 22511788
Protein oligomerization DST 20589 Nakayama K. et al. (2007) Arabidopsis Cor15am is a chloroplast stromal protein that has cryoprotective activity and forms oligomers. Plant Physiol. 144, 513-523. PMID: 17384167
Protein oligomerization BS3 21580, 21585, 21586 Sachais B. S. et al. (2012) Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia. Blood. 119, 5955-5962. PMID: 22452981
Protein oligomerization DMS 20700 Sen D. et al. (2012) Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase. J Biol Chem. 287, 14545-14556. PMID: 22383523
Protein oligomerization Sulfo-EGS 21566 Severin S. et al. (2011) Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling. J Biol Chem. 286, 4107-4116. PMID: 21098033
Protein oligomerization DFDNB 21525 Sheridan J. T. et al. (2011) Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A. J Biol Chem. 286, 1381-1388. PMID: 21056985
Protein oligomerization AMAS 22295 Strang C. et al. (2001) A central role for the T1 domain in voltage-gated potassium channel formation and function. J Biol Chem. 276, 28493-28502. PMID: 11312262
Protein oligomerization SIA 22349 Strang C. et al. (2001) A central role for the T1 domain in voltage-gated potassium channel formation and function. J Biol Chem. 276, 28493-28502. PMID: 11312262
Protein oligomerization DSG 20593 Strang C. et al. (2001) A central role for the T1 domain in voltage-gated potassium channel formation and function. J Biol Chem. 276, 28493-502. PMID: 11312262
Protein oligomerization TMEA 33043 Studdert C. A. and Parkinson J. S. (2004) Crosslinking snapshots of bacterial chemoreceptor squads. Proc Natl Acad Sci U S A. 101, 2117-2122. PMID: 14769919
Protein oligomerization AMAS 22295 Tran H. J. et al. (2005) Analysis of RovA, a transcriptional regulator of Yersinia pseudotuberculosis virulence that acts through antirepression and direct transcriptional activation. J Biol Chem. 280, 42423-42432. PMID: 16257976
Protein oligomerization DSG 20593 Wang Z. et al. (2012) The structural basis for the oligomerization of the N-terminal domain of SATB1. Nucleic Acids Res. 40, 4193-4202. PMID: 22241778
Protein oligomerization Sulfo-EGS 21566 Xayarath B. et al. (2011) A novel C-terminal mutation resulting in constitutive activation of the Listeria monocytogenes central virulence regulatory factor PrfA. Microbiology. 157, 3138-3149. PMID: 21835879
Protein oligomerization DST 20589 Yu Y. et al. (2009) Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A. 106, 11558-11563. PMID: 19556541
Protein labeling (dendrimer) KMUH 22111 Yang W. et al. (2006) Molecular targeting and treatment of EGFRvIII-positive gliomas using boronated monoclonal antibody L8A4. Clin Cancer Res. 12, 3792-3802. PMID: 16778107
Protein labeling (dendrimer) KMUH 22111 Yang W. et al. (2006) Molecular targeting and treatment of EGFRvIII-positive gliomas using boronated monoclonal antibody L8A4. Clin Cancer Res. 12, 3792-3802. PMID: 16778107
Protein labeling Sulfo-LC-SPDP 21650 Backer M. V. et al. (2005) Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature. Mol Cancer Ther. 4, 1423-1429. PMID: 16170035
Protein labeling EMCH 22106 Bao X. et al. (2007) Change in permeant size selectivity by phosphorylation of connexin 43 gap-junctional hemichannels by PKC. Proc Natl Acad Sci U S A. 104, 4919-4924. PMID: 17360407
Protein labeling PDPH 22301 Govindan S. V. et al. (1995) Site-specific modifications of light chain glycosylated antilymphoma (LL2) and anti-carcinoembryonic antigen (hImmu-14-N) antibody divalent f1agments. Cancer Res. 55, 5721s-5725s. PMID: 7493334
Protein immobilization onto chip or slide BS(PEG)5, BS(PEG)9 21581, 21582 Blank K. et al. (2003) A force-based protein biochip. Proc Natl Acad Sci U S A. 100, 11356-11360. PMID: 12975526
Protein immobilization onto chip or slide BS(PEG)5, BS(PEG)9 21581, 21582 Blank K. et al. (2003) A force-based protein biochip. Proc Natl Acad Sci U S A. 100, 11356-11360. PMID: 12975526
Protein immobilization onto chip or slide EMCS 22308 Brandt O. et al. (2003) PNA microarrays for hybridisation of unlabelled DNA samples. Nucleic Acids Res. 31, e119. PMID: 14500847
Protein immobilization onto chip or slide PMPI 28100 Chirayil S. et al. (2009) Discovering ligands for a microRNA precursor with peptoid microarrays. Nucleic Acids Res. 37, 5486-5497. PMID: 19561197
Protein immobilization onto chip or slide NHS 25400 Ding J. et al. (2012) Structural insights into the Pseudomonas aeruginosa type VI virulence effector Tse1 bacteriolysis and self-protection mechanisms. J Biol Chem. 287, 26911-26920. PMID: 22700987
Protein immobilization onto chip or slide Sulfo-NHS 24510, 24520, 24525 Guha Thakurta S. et al. (2012) Investigation of platelet responses and clotting characteristics of in situ albumin binding surfaces. J Biomater Appl. 26, 529-547. PMID: 20819918
Protein immobilization onto chip or slide MPBH 22305 Gunning A. P. et al. (2008) Mapping specific adhesive interactions on living human intestinal epithelial cells with atomic force microscopy. FASEB J. 22, 2331-2339. PMID: 18263697
Protein immobilization onto chip or slide EMCS 22308 Hamby C. V. et al. (2005) Use of Peptide library screening to detect a previously unknown linear diagnostic epitope: proof of principle by use of lyme disease sera. Clin Diagn Lab Immunol. 12, 801-807. PMID: 16002626
Protein immobilization onto chip or slide NHS 25400 Kim D. K. et al. (2012) Orphan nuclear receptor estrogen-related receptor gamma (ERRgamma) is key regulator of hepatic gluconeogenesis. J Biol Chem. 287, 21628-21639. PMID: 22549789
Protein immobilization onto chip or slide Sulfo-NHS 24510, 24520, 24525 Leysath C. E. et al. (2011) Mouse monoclonal antibodies to anthrax edema factor protect against infection. Infect Immun. 79, 4609-4616. PMID: 21911463
Protein immobilization onto chip or slide Sulfo-GMBS 22324 Liu S. H. et al. (2006) Studying the protein organization of the postsynaptic density by a novel solid phase- and chemical cross-linking-based technology. Mol Cell Proteomics. 5, 1019-1032. PMID: 16501281
Protein immobilization onto chip or slide NHS 25400 Matsumura H. et al. (2012) Crystal structure of the N-terminal domain of the yeast general corepressor Tup1p and its functional implications. J Biol Chem. 287, 26528-26538. PMID: 22707714
Protein immobilization onto chip or slide NHS 25400 Noborn F. et al. (2012) Heparan sulfate dissociates serum amyloid A (SAA) from acute-phase high-density lipoprotein, promoting SAA aggregation. J Biol Chem. 287, 25669-25677. PMID: 22654109
Protein immobilization onto chip or slide NHS 25400 Wollein Waldetoft K. et al. (2012) Streptococcal surface proteins activate the contact system and control its antibacterial activity. J Biol Chem. 287, 25010-25018. PMID: 22648411
Protein immobilization onto chip or slide NHS 25400 Yoon S. I. et al. (2012) Epstein-Barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling properties. J Biol Chem. 287, 26586-26595. PMID: 22692218
Protein immobilization onto chip or slide Sulfo-LC-SPDP 21650 Zhao D. et al. (2011) Carbon nanotubes enhance CpG uptake and potentiate antiglioma immunity. Clin Cancer Res. 17, 771-782. PMID: 21088258
Protein alkylation EMCH 22106 Ouertatani-Sakouhi H. et al. (2010) Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action. J Biol Chem. 285, 26581-26598. PMID: 20516071
Peptide-protein interaction analysis DSS 21555, 21655, 21658 Bofill-Cardona E. et al. (2000) Binding of calmodulin to the D2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch. J Biol Chem. 275, 32672-32680. PMID: 10926927
Peptide-protein interaction analysis TSAT 33063 Bofill-Cardona E. et al. (2000) Binding of calmodulin to the D2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch. J Biol Chem. 275, 32672-32680. PMID: 10926927
Peptide-protein interaction analysis DMS 20700 Chang T. W. et al. (2012) Outer membrane lipoprotein Lpp is Gram-negative bacterial cell surface receptor for cationic antimicrobial peptides. J Biol Chem. 287, 418-428. PMID: 22084237
Peptide-protein interaction analysis LC-SMCC 22362 Ruffolo S. C. and Shore G. C. (2003) BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization. J Biol Chem. 278, 25039-25045. PMID: 12721291
Peptide-protein interaction analysis SIAB 22329 Weng G. et al. (1996) Gbeta subunit interacts with a peptide encoding region 956-982 of adenylyl cyclase 2. Cross-linking of the peptide to free Gbetagamma but not the heterotrimer. J Biol Chem. 271, 26445-26448. PMID: 8900107
Peptide-drug conjugation SMCC 22360 Hatakeyama S. et al. (2011) Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide. Proc Natl Acad Sci U S A. 108, 19587-19592. PMID: 22114188
Nucleic acid labeling EDC 77149, 22980, 22981 Overath T. et al. (2012) Mapping of O-GlcNAc sites of 20 S proteasome subunits and Hsp90 by a novel biotin-cystamine tag. Mol Cell Proteomics. 11, 467-477. PMID: 22556278
Nucleic acid immobilization Sulfo-SMCC 22122, 22322, 22622 Adessi C. et al. (2000) Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms. Nucleic Acids Res. 28, E87. PMID: 11024189
Nucleic acid immobilization GMBS 22309 Adessi C. et al. (2000) Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms. Nucleic Acids Res. 28, E87. PMID: 11024189
Nucleic acid immobilization MBS 22311 Adessi C. et al. (2000) Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms. Nucleic Acids Res. 28, E87. PMID: 11024189
Nucleic acid immobilization Sulfo-MBS 22312 Adessi C. et al. (2000) Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms. Nucleic Acids Res. 28, E87. PMID: 11024189
Nucleic acid immobilization Sulfo-GMBS 22324 Adessi C. et al. (2000) Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms. Nucleic Acids Res. 28, E87. PMID: 11024189
Nucleic acid immobilization Sulfo-SIAB 22327 Adessi C. et al. (2000) Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms. Nucleic Acids Res. 28, E87. PMID: 11024189
Nucleic acid immobilization SMCC 22360 Adessi C. et al. (2000) Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms. Nucleic Acids Res. 28, E87. PMID: 11024189
Nucleic acid immobilization EDC 77149, 22980, 22981 Adessi C. et al. (2000) Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms. Nucleic Acids Res. 28, E87. PMID: 11024189
Nucleic acid immobilization Sulfo-SIAB 22327 Allerson C. R. et al. (2003) A high-capacity RNA affinity column for the purification of human IRP1 and IRP2 overexpressed in Pichia pastoris. RNA. 9, 364-374. PMID: 12592010
Nucleic acid immobilization SIAB 22329 Andreadis J. D. and Chrisey L. A. (2000) Use of immobilized PCR primers to generate covalently immobilized DNAs for in vitro transcription/translation reactions. Nucleic Acids Res. 28, e5. PMID: 10606673
Nucleic acid immobilization GMBS 22309 Chrisey L. A. et al. (1996) Covalent attachment of synthetic DNA to self-assembled monolayer films. Nucleic Acids Res. 24, 3031-3039. PMID: 8760890
Nucleic acid immobilization MBS 22311 Chrisey L. A. et al. (1996) Covalent attachment of synthetic DNA to self-assembled monolayer films. Nucleic Acids Res. 24, 3031-3039. PMID: 8760890
Nucleic acid immobilization SIAB 22329 Chrisey L. A. et al. (1996) Covalent attachment of synthetic DNA to self-assembled monolayer films. Nucleic Acids Res. 24, 3031-3039. PMID: 8760890
Nucleic acid immobilization SMCC 22360 Chrisey L. A. et al. (1996) Covalent attachment of synthetic DNA to self-assembled monolayer films. Nucleic Acids Res. 24, 3031-3039. PMID: 8760890
Nucleic acid immobilization SMPB 22416 Chrisey L. A. et al. (1996) Covalent attachment of synthetic DNA to self-assembled monolayer films. Nucleic Acids Res. 24, 3031-3039. PMID: 8760890
Nucleic acid immobilization Sulfo-SIAB 22327 Crawford J. B. and Patton J. G. (2006) Activation of alpha-tropomyosin exon 2 is regulated by the SR protein 9G8 and heterogeneous nuclear ribonucleoproteins H and F. Mol Cell Biol. 26, 8791-8802. PMID: 17000773
Nucleic acid immobilization Sulfo-EMCS 22307 Fixe F. et al. (2004) An on-chip thin film photodetector for the quantification of DNA probes and targets in microarrays. Nucleic Acids Res. 32, e70. PMID: 15148343
Nucleic acid immobilization Sulfo-EMCS 22307 Fixe F. et al. (2004) Functionalization of poly(methyl methacrylate) (PMMA) as a substrate for DNA microarrays. Nucleic Acids Res. 32, e9. PMID: 14718554
Nucleic acid immobilization EDC 77149, 22980, 22981 Li Z. et al. (2012) Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs. Nucleic Acids Res. 40, 6787-6799. PMID: 22492706
Nucleic acid immobilization LC-SMCC 22362 Masuko M. (2003) Hybridization of an immobilized PNA probe with its complementary oligodeoxyribonucleotide on the surface of silica glass. Nucleic Acids Res Suppl, 145-146. PMID: 14510422
Nucleic acid immobilization PMPI 28100 Pourmand N. et al. (2006) Direct electrical detection of DNA synthesis. Proc Natl Acad Sci U S A. 103, 6466-6470. PMID: 16614066
Nucleic acid immobilization PMPI 28100 Shen G. et al. (2004) X-ray photoelectron spectroscopy and infrared spectroscopy study of maleimide-activated supports for immobilization of oligodeoxyribonucleotides. Nucleic Acids Res. 32, 5973-5980. PMID: 15537837
Nucleic acid immobilization SIAB 22329 Tang K. et al. (1999) Chip-based genotyping by mass spectrometry. Proc Natl Acad Sci U S A. 96, 10016-10020. PMID: 10468554
Matrix formation DST 20589 Matsuda M. et al. (2012) Enhanced tissue penetration-induced high bonding strength of a novel tissue adhesive composed of cholesteryl group-modified gelatin and disuccinimidyl tartarate. Colloids Surf B Biointerfaces. 91, 48-56. PMID: 22088758
Matrix formation BS3 21580, 21585, 21586 Ohgo K. et al. (2012) Resolving nitrogen-15 and proton chemical shifts for mobile segments of elastin with two-dimensional NMR spectroscopy. J Biol Chem. 287, 18201-18209. PMID: 22474297
Inorganic particle conjugation DCC 20320 Harney A. S. et al. (2009) Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate. Proc Natl Acad Sci U S A. 106, 13667-13672. PMID: 19666616
Inorganic particle conjugation DCC 20320 Song E. Q. et al. (2009) Tumor cell targeting using folate-conjugated fluorescent quantum dots and receptor-mediated endocytosis. Clin Chem. 55, 955-963. PMID: 19282359
Inorganic particle conjugation SMCC 22360 Sperling R. A. and Parak W. J. (2010) Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Philos Transact A Math Phys Eng Sci. 368, 1333-1383. PMID: 20156828
Inorganic particle conjugation Sulfo-NHS 24510, 24520, 24525 Sperling R. A. and Parak W. J. (2010) Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Philos Transact A Math Phys Eng Sci. 368, 1333-1383. PMID: 20156828
Inorganic particle conjugation EDC 77149, 22980, 22981 Sperling R. A. and Parak W. J. (2010) Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Philos Transact A Math Phys Eng Sci. 368, 1333-1383. PMID: 20156828
in vivo protein crosslinking BMH 22330 Ahmad R. et al. (2012) The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function. J Biol Chem. 287, 20866-20875. PMID: 22544745
in vivo protein crosslinking DSP 22585, 22586 Bue C. A. and Barlowe C. (2009) Molecular dissection of Erv26p identifies separable cargo binding and coat protein sorting activities. J Biol Chem. 284, 24049-24060. PMID: 19574229
in vivo protein crosslinking DFDNB 21525 Geula S. et al. (2012) Structure-based analysis of VDAC1 protein: defining oligomer contact sites. J Biol Chem. 287, 2179-2190. PMID: 22117062
in vivo protein crosslinking EGS 21565 Geula S. et al. (2012) Structure-based analysis of VDAC1 protein: defining oligomer contact sites. J Biol Chem. 287, 2179-2190. PMID: 22117062
in vivo protein crosslinking BMOE 22323 Geula S. et al. (2012) Structure-based analysis of VDAC1 protein: defining oligomer contact sites. J Biol Chem. 287, 2179-2190. PMID: 22117062
in vivo protein crosslinking SMPB 22416 Goldoni S. et al. (2009) Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol. 185, 743-754. PMID: 19433454
in vivo protein crosslinking DSP 22585, 22586 Larimore J. et al. (2011) The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Mol Biol Cell. 22, 4854-67. PMID: 21998198
in vivo protein crosslinking DSP 22585, 22586 Larimore J. et al. (2011) The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Mol Biol Cell. 22, 4854-67. PMID: 21998198
in vivo protein crosslinking DSP 22585, 22586 Penmatsa H. et al. (2010) Compartmentalized cyclic adenosine 3',5'-monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains. Mol Biol Cell. 21, 1097-110. PMID: 20089840
in vivo protein crosslinking DTME 22335 Simonin A. and Fuster D. (2010) Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function. J Biol Chem. 285, 38293-38303. PMID: 20855896
in vivo protein crosslinking DTME 22335 Smith A. L. et al. (2012) Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin. Mol Biol Cell. 23, 99-110. PMID: 22031287
in vivo protein crosslinking DSP 22585, 22586 Smith A. L. et al. (2012) Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin. Mol Biol Cell. 23, 99-110. PMID: 22031287
in vivo protein crosslinking DTME 22335 Van Itallie C. M. et al. (2011) Claudin-2 forms homodimers and is a component of a high molecular weight protein complex. J Biol Chem. 286, 3442-3450. PMID: 21098027
in vivo protein crosslinking DSS 21555, 21655, 21658 van Meeteren L. A. et al. (2012) Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. J Biol Chem. 287, 18551-18561. PMID: 22493445
in vivo protein crosslinking BS3 21580, 21585, 21586 van Meeteren L. A. et al. (2012) Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. J Biol Chem. 287, 18551-18561. PMID: 22493445
in vivo protein crosslinking DSP 22585, 22586 Zlatic S. A. et al. (2011) Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells. Mol Biol Cell. 22, 1699-715. PMID: 21411634
Hormone-drug conjugation DCC 20320 Sundaram S. et al. (2009) Luteinizing hormone-releasing hormone receptor-targeted deslorelin-docetaxel conjugate enhances efficacy of docetaxel in prostate cancer therapy. Mol Cancer Ther. 8, 1655-1665. PMID: 19509261
Chromatin immunoprecipitation (ChIP) DSG 20593 Brasier A. R. et al. (2011) RelA Ser276 phosphorylation-coupled Lys310 acetylation controls transcriptional elongation of inflammatory cytokines in respiratory syncytial virus infection. J Virol. 85, 11752-69. PMID: 21900162
Chromatin immunoprecipitation (ChIP) DSP 22585, 22586 Denver R. J. and Williamson K. E. (2009) Identification of a thyroid hormone response element in the mouse Kruppel-like factor 9 gene to explain its postnatal expression in the brain. Endocrinology. 150, 3935-3943. PMID: 19359381
Chromatin immunoprecipitation (ChIP) DSG 20593 Mardaryev A. N. et al. (2011) Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development. 138, 4843-52. PMID: 22028024
Chromatin immunoprecipitation (ChIP) DMA 20660 Mizutani A. et al. (2011) Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells. J Biol Chem. 286, 29848-29860. PMID: 21646355
Chromatin immunoprecipitation (ChIP) EGS 21565 Mokry M. et al. (2012) Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes. Nucleic Acids Res. 40, 148-158. PMID: 21914722
Chromatin immunoprecipitation (ChIP) EGS 21565 Pourcet B. et al. (2011) LXRalpha regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8. Circ Res. 109, 492-501. PMID: 21757649
Chromatin immunoprecipitation (ChIP) DSG 20593 Sen N. and Snyder S. H. (2011) Neurotrophin-mediated degradation of histone methyltransferase by S-nitrosylation cascade regulates neuronal differentiation. Proc Natl Acad Sci U S A. 108, 20178-83. PMID: 22123949
Chromatin immunoprecipitation (ChIP) DTBP 20665 Zhu B. et al. (2012) Peroxisome proliferator-activated receptor beta/delta cross talks with E2F and attenuates mitosis in HRAS-expressing cells. Mol Cell Biol. 32, 2065-2082. PMID: 22473992
Cell immobilization DTBP 20665 Bhattacharya M. et al. (2012) IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 303, L12-19. PMID: 22561460
Carbohydrate-metabolite conjugation PDPH 22301 Atkinson S. F. et al. (2001) Conjugation of folate via gelonin carbohydrate residues retains ribosomal-inactivating properties of the toxin and permits targeting to folate receptor positive cells. J Biol Chem. 276, 27930-27935. PMID: 11359781
Carbohydrate-metabolite conjugation Sulfo-NHS 24510, 24520, 24525 Bergfeld A. K. et al. (2012) Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: ELUCIDATING THE INTRACELLULAR FATE OF THE NON-HUMAN SIALIC ACID N-GLYCOLYLNEURAMINIC ACID. J Biol Chem. 287, 28865-28881. PMID: 22692205
Carbohydrate-metabolite conjugation EDC 77149, 22980, 22981 Bergfeld A. K. et al. (2012) Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: ELUCIDATING THE INTRACELLULAR FATE OF THE NON-HUMAN SIALIC ACID N-GLYCOLYLNEURAMINIC ACID. J Biol Chem. 287, 28865-28881. PMID: 22692205
Antigen formation for immunization Sulfo-EMCS 22307 Anderson J. P. et al. (2006) Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J Biol Chem. 281, 29739-29752. PMID: 16847063
Antigen formation for immunization Sulfo-SMCC 22122, 22322, 22622 Betting D. J. et al. (2008) Sulfhydryl-based tumor antigen-carrier protein conjugates stimulate superior antitumor immunity against B cell lymphomas. J Immunol. 181, 4131-4140. PMID: 18768870
Antigen formation for immunization GMBS 22309 Fujiwara K. et al. (1998) Preparation of monoclonal antibodies against N-(gamma-maleimidobutyryloxy)succinimide (GMBS)-conjugated acetylspermine, and development of an enzyme-linked immunosorbent assay (ELISA) for N1,N12-diacetylspermine. J Biochem. 124, 244-249. PMID: 9644270
Antigen formation for immunization GMBS 22309 Lee H. S. et al. (2010) Obox4 critically regulates cAMP-dependent meiotic arrest and MI-MII transition in oocytes. FASEB J. 24, 2314-2324. PMID: 20154267
Antigen formation for immunization GMBS 22309 Lee S. J. et al. (2011) Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver. Blood. 117, 5215-5223. PMID: 21427291
Antibody/protein immobilization onto
extracelular matrix
Sulfo-SANPAH 22589 Betz T. et al. (2011) Growth cones as soft and weak force generators. Proc Natl Acad Sci U S A. 108, 13420-13425. PMID: 21813757
Antibody/protein immobilization onto
extracelular matrix
Sulfo-SANPAH 22589 Elliott C. G. et al. (2012) Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair. J Cell Sci. 125, 121-132. PMID: 22266908
Antibody/protein immobilization onto
extracelular matrix
Sulfo-SANPAH 22589 Liu Z. et al. (2011) Alpha-actinin-4 and CLP36 protein deficiencies contribute to podocyte defects in multiple human glomerulopathies. J Biol Chem. 286, 30795-30805. PMID: 21680739
Antibody/protein immobilization onto
extracelular matrix
Sulfo-SANPAH 22589 Mierke C. T. et al. (2011) Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion. J Biol Chem. 286, 34858-34871. PMID: 21828044
Antibody/protein immobilization onto
extracelular matrix
Sulfo-SANPAH 22589 Oakes P. W. et al. (2012) Tension is required but not sufficient for focal adhesion maturation without a stress fiber template. J Cell Biol. 196, 363-374. PMID: 22291038
Antibody/protein immobilization onto resin DMS 20700 Guergova-Kuras M. et al. (2011) Discovery of lung cancer biomarkers by profiling the plasma proteome with monoclonal antibody libraries. Mol Cell Proteomics. 10, M111 010298. PMID: 21947365
Antibody/protein immobilization onto resin DMP 21666, 21667 Guergova-Kuras M. et al. (2011) Discovery of lung cancer biomarkers by profiling the plasma proteome with monoclonal antibody libraries. Mol Cell Proteomics. 10, M111 010298. PMID: 21947365
Antibody/protein immobilization onto resin GMBS 22309 Gunning A. P. et al. (2008) Mapping specific adhesive interactions on living human intestinal epithelial cells with atomic force microscopy. FASEB J. 22, 2331-2339. PMID: 18263697
Antibody/protein immobilization onto resin MPBH 22305 Gunning A. P. et al. (2009) Recognition of galactan components of pectin by galectin-3. FASEB J. 23, 415-424. PMID: 18832596
Antibody/protein immobilization onto resin GMBS 22309 Gunning A. P. et al. (2009) Recognition of galactan components of pectin by galectin-3. FASEB J. 23, 415-424. PMID: 18832596
Antibody/protein immobilization onto resin EMCS 22308 Harma H. et al. (2000) Miniature single-particle immunoassay for prostate-specific antigen in serum using recombinant Fab fragments. Clin Chem. 46, 1755-1761. PMID: 11067810
Antibody/protein immobilization onto resin Sulfo-SIAB 22327 Harma H. et al. (2000) Miniature single-particle immunoassay for prostate-specific antigen in serum using recombinant Fab fragments. Clin Chem. 46, 1755-1761. PMID: 11067810
Antibody/protein immobilization onto resin NHS 25400 Olsson N. et al. (2012) Quantitative proteomics targeting classes of motif-containing peptides using immunoaffinity-based mass spectrometry. Mol Cell Proteomics. 11, 342-354. PMID: 22543061
Antibody/protein immobilization onto resin EDC 77149, 22980, 22981 Olsson N. et al. (2012) Quantitative proteomics targeting classes of motif-containing peptides using immunoaffinity-based mass spectrometry. Mol Cell Proteomics. 11, 342-354. PMID: 22543061
Antibody/protein immobilization onto resin DMA 20660 Peng L. et al. (2012) SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol. 32, 2823-2836. PMID: 22586264
Antibody/protein immobilization onto resin Sulfo-SMPB 22317 Pu W. T. et al. (1999) pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol. 19, 4113-4120. PMID: 10330151
Antibody/protein immobilization onto resin DSS 21555, 21655, 21658 Sarkar D. K. et al. (2012) Opiate antagonist prevents mu- and delta-opiate receptor dimerization to facilitate ability of agonist to control ethanol-altered natural killer cell functions and mammary tumor growth. J Biol Chem. 287, 16734-16747. PMID: 22451667
Antibody/protein immobilization onto resin LC-SPDP 21651 Yuan J. and Berg H. C. (2008) Resurrection of the flagellar rotary motor near zero load. Proc Natl Acad Sci U S A. 105, 1182-1185. PMID: 18202173
Antibody/protein immobilization onto resin Sulfo-LC-SPDP 21650 Zhang J. et al. (2008) Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method. Mol Cell Proteomics. 7, 1378-1388. PMID: 18296695
Antibody/protein immobilization onto resin SPDP 21857 Zhou H. et al. (2011) Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells. Mol Cancer Ther. 10, 1276-1288. PMID: 21586630
Antibody-liposome conjugation Sulfo-KMUS 21111 DeCory T. R. et al. (2005) Development of an immunomagnetic bead-immunoliposome fluorescence assay for rapid detection of Escherichia coli O157:H7 in aqueous samples and comparison of the assay with a standard microbiological method. Appl Environ Microbiol. 71, 1856-1864. PMID: 15812012
Antibody-drug conjugation SMCC 22360 Kovtun Y. V. et al. (2010) Antibody-maytansinoid conjugates designed to bypass multidrug resistance. Cancer Res. 70, 2528-2537. PMID: 20197459